Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels
Background: Antibiotic therapy used to eradicate Helicobacter pylori has been associated with changes in plasma ghrelin and alterations in the gut microbiota. On the other hand, changes in ghrelin levels have been related to changes in gut microbiota composition. Our aim was to evaluate the relation...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.712908/full |
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| author | Gracia Mª Martín-Núñez Gracia Mª Martín-Núñez Isabel Cornejo-Pareja Isabel Cornejo-Pareja Mercedes Clemente-Postigo Mercedes Clemente-Postigo Francisco J. Tinahones Francisco J. Tinahones Isabel Moreno-Indias Isabel Moreno-Indias |
| author_facet | Gracia Mª Martín-Núñez Gracia Mª Martín-Núñez Isabel Cornejo-Pareja Isabel Cornejo-Pareja Mercedes Clemente-Postigo Mercedes Clemente-Postigo Francisco J. Tinahones Francisco J. Tinahones Isabel Moreno-Indias Isabel Moreno-Indias |
| author_sort | Gracia Mª Martín-Núñez |
| collection | DOAJ |
| description | Background: Antibiotic therapy used to eradicate Helicobacter pylori has been associated with changes in plasma ghrelin and alterations in the gut microbiota. On the other hand, changes in ghrelin levels have been related to changes in gut microbiota composition. Our aim was to evaluate the relationship between changes in the gut microbiota and ghrelin levels in H. pylori infected patients who received antibiotic treatment for its eradication.Methods: A prospective case-control study that included forty H. pylori-positive patients who received eradication therapy (omeprazole, clarithromycin, and amoxicillin) and twenty healthy H. pylori antigen-negative participants. Patients were evaluated, including clinical, anthropometric and dietary variables, before and 2 months after treatment. Gut microbiota composition was analyzed through 16S rRNA amplicon sequencing (IlluminaMiSeq).Results: Changes in gut microbiota profiles and decrease in ghrelin levels were identified after H. pylori eradication treatment. Gut bacteria such as Bifidobacterium longum, Bacteroides, Prevotella, Parabacteroides distasonis, and RS045 have been linked to ghrelin levels fasting and/or post meals. Changes in the abundance of Lachnospiraceae, its genus Blautia, as well as Prevotella stercorea, and Megasphaera have been inversely associated with changes in ghrelin after eradication treatment.Conclusions: Eradication treatment for H. pylori produces changes in the composition of the intestinal microbiota and ghrelin levels. The imbalance between lactate producers such as Blautia, and lactate consumers such as Megasphaera, Lachnospiraceae, or Prevotella, could trigger changes related to ghrelin levels under the alteration of the eradication therapy used for H. pylori. In addition, acetate producing bacteria such as B. longum, Bacteroides, and P. distasonis could also play an important role in ghrelin regulation. |
| first_indexed | 2024-12-22T00:18:15Z |
| format | Article |
| id | doaj.art-fbaa339f55e046f383ece177d9aab40b |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-22T00:18:15Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-fbaa339f55e046f383ece177d9aab40b2022-12-21T18:45:14ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-08-01810.3389/fmed.2021.712908712908Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin LevelsGracia Mª Martín-Núñez0Gracia Mª Martín-Núñez1Isabel Cornejo-Pareja2Isabel Cornejo-Pareja3Mercedes Clemente-Postigo4Mercedes Clemente-Postigo5Francisco J. Tinahones6Francisco J. Tinahones7Isabel Moreno-Indias8Isabel Moreno-Indias9Department of Endocrinology and Nutrition, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Málaga, SpainCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainDepartment of Endocrinology and Nutrition, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Málaga, SpainCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainDepartment of Cell Biology, Physiology, and Immunology, Maimónides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba/Reina Sofia University Hospital, Córdoba, SpainDepartment of Endocrinology and Nutrition, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Málaga, SpainCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainDepartment of Endocrinology and Nutrition, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Málaga, SpainCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainBackground: Antibiotic therapy used to eradicate Helicobacter pylori has been associated with changes in plasma ghrelin and alterations in the gut microbiota. On the other hand, changes in ghrelin levels have been related to changes in gut microbiota composition. Our aim was to evaluate the relationship between changes in the gut microbiota and ghrelin levels in H. pylori infected patients who received antibiotic treatment for its eradication.Methods: A prospective case-control study that included forty H. pylori-positive patients who received eradication therapy (omeprazole, clarithromycin, and amoxicillin) and twenty healthy H. pylori antigen-negative participants. Patients were evaluated, including clinical, anthropometric and dietary variables, before and 2 months after treatment. Gut microbiota composition was analyzed through 16S rRNA amplicon sequencing (IlluminaMiSeq).Results: Changes in gut microbiota profiles and decrease in ghrelin levels were identified after H. pylori eradication treatment. Gut bacteria such as Bifidobacterium longum, Bacteroides, Prevotella, Parabacteroides distasonis, and RS045 have been linked to ghrelin levels fasting and/or post meals. Changes in the abundance of Lachnospiraceae, its genus Blautia, as well as Prevotella stercorea, and Megasphaera have been inversely associated with changes in ghrelin after eradication treatment.Conclusions: Eradication treatment for H. pylori produces changes in the composition of the intestinal microbiota and ghrelin levels. The imbalance between lactate producers such as Blautia, and lactate consumers such as Megasphaera, Lachnospiraceae, or Prevotella, could trigger changes related to ghrelin levels under the alteration of the eradication therapy used for H. pylori. In addition, acetate producing bacteria such as B. longum, Bacteroides, and P. distasonis could also play an important role in ghrelin regulation.https://www.frontiersin.org/articles/10.3389/fmed.2021.712908/fullHelicobacter pylorigut microbiotaghrelineradication treatmentantibiotic |
| spellingShingle | Gracia Mª Martín-Núñez Gracia Mª Martín-Núñez Isabel Cornejo-Pareja Isabel Cornejo-Pareja Mercedes Clemente-Postigo Mercedes Clemente-Postigo Francisco J. Tinahones Francisco J. Tinahones Isabel Moreno-Indias Isabel Moreno-Indias Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels Frontiers in Medicine Helicobacter pylori gut microbiota ghrelin eradication treatment antibiotic |
| title | Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels |
| title_full | Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels |
| title_fullStr | Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels |
| title_full_unstemmed | Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels |
| title_short | Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels |
| title_sort | helicobacter pylori eradication therapy affect the gut microbiota and ghrelin levels |
| topic | Helicobacter pylori gut microbiota ghrelin eradication treatment antibiotic |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.712908/full |
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