Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats
Abstract Objective Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of low dose administration of green coffee extract on body weight, serum lipids, and TNF-α level in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13104-020-05052-y |
| _version_ | 1818151448216600576 |
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| author | Cimi Ilmiawati Fajar Fitri Zelly Dia Rofinda Mohamad Reza |
| author_facet | Cimi Ilmiawati Fajar Fitri Zelly Dia Rofinda Mohamad Reza |
| author_sort | Cimi Ilmiawati |
| collection | DOAJ |
| description | Abstract Objective Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of low dose administration of green coffee extract on body weight, serum lipids, and TNF-α level in high-fat diet-induced obese rats. Results Administration of green coffee extract to high-fat diet-induced obese male Wistar rats (Rattus norvegicus) reduced body weight, total serum cholesterol, and triglyceride at the dose of 10, 20, and 40 mg/kg BW/day; lowered serum LDL-cholesterol at the treatment dose of 20 mg/kg BW/day (p < 0.05). The effective dose to decrease serum TNF-α level was 40 mg/kg BW/day, while the effective dose to improve the lipid profile was 10 mg/kg BW/day. These results support the potential use of green coffee extract as a functional nutrient in the management of obesity. |
| first_indexed | 2024-12-11T13:38:59Z |
| format | Article |
| id | doaj.art-fbaa449a1b4641a4a56ba8a29abee2f7 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-11T13:38:59Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-fbaa449a1b4641a4a56ba8a29abee2f72022-12-22T01:04:54ZengBMCBMC Research Notes1756-05002020-04-011311510.1186/s13104-020-05052-yGreen coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese ratsCimi Ilmiawati0Fajar Fitri1Zelly Dia Rofinda2Mohamad Reza3Department of Pharmacology, Faculty of Medicine, Andalas UniversityPostgraduate Student, Graduate Program of Biomedical Science, Faculty of Medicine, Andalas UniversityDepartment of Clinical Pathology, Faculty of Medicine, Andalas UniversityDepartment of Biology, Faculty of Medicine, Andalas UniversityAbstract Objective Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of low dose administration of green coffee extract on body weight, serum lipids, and TNF-α level in high-fat diet-induced obese rats. Results Administration of green coffee extract to high-fat diet-induced obese male Wistar rats (Rattus norvegicus) reduced body weight, total serum cholesterol, and triglyceride at the dose of 10, 20, and 40 mg/kg BW/day; lowered serum LDL-cholesterol at the treatment dose of 20 mg/kg BW/day (p < 0.05). The effective dose to decrease serum TNF-α level was 40 mg/kg BW/day, while the effective dose to improve the lipid profile was 10 mg/kg BW/day. These results support the potential use of green coffee extract as a functional nutrient in the management of obesity.http://link.springer.com/article/10.1186/s13104-020-05052-yBody weightCholesterolGreen coffee extractLipid profileObesityTNF-α |
| spellingShingle | Cimi Ilmiawati Fajar Fitri Zelly Dia Rofinda Mohamad Reza Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats BMC Research Notes Body weight Cholesterol Green coffee extract Lipid profile Obesity TNF-α |
| title | Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats |
| title_full | Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats |
| title_fullStr | Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats |
| title_full_unstemmed | Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats |
| title_short | Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats |
| title_sort | green coffee extract modifies body weight serum lipids and tnf α in high fat diet induced obese rats |
| topic | Body weight Cholesterol Green coffee extract Lipid profile Obesity TNF-α |
| url | http://link.springer.com/article/10.1186/s13104-020-05052-y |
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