Parallel Simulation of Cellular Flow in Microvessels Using a Particle Method
We developed a numerical method for large-scale simulations of cellular flow in microvessels. We employed a particle method, where all blood components were modeled using a finite number of particles. Red blood cell deformation was modeled by a spring network of membrane particles. A domain decompos...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Japan Society of Mechanical Engineers
2012-02-01
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| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/7/1/7_1_57/_pdf/-char/en |
| _version_ | 1818532415206850560 |
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| author | Davod ALIZADEHRAD Yohsuke IMAI Keita NAKAAKI Takuji ISHIKAWA Takami YAMAGUCHI |
| author_facet | Davod ALIZADEHRAD Yohsuke IMAI Keita NAKAAKI Takuji ISHIKAWA Takami YAMAGUCHI |
| author_sort | Davod ALIZADEHRAD |
| collection | DOAJ |
| description | We developed a numerical method for large-scale simulations of cellular flow in microvessels. We employed a particle method, where all blood components were modeled using a finite number of particles. Red blood cell deformation was modeled by a spring network of membrane particles. A domain decomposition method was used for parallel implementation on distributed memory systems. In a strong scaling test up to 64 CPU cores, we obtained a linear speedup with the number of CPU cores, and demonstrated that our model can simulate O(103) red blood cells in vessels a few tens of micrometers in diameter. For quantitative validation, we analyzed the Fåhræus effect and the formation of a cell-depleted peripheral layer. Simulations were performed for tube hematocrit ranging from 20 to 45%, and microvessel diameters from 9 to 50 µm. Our numerical results were in good agreement with previous experimental results both for the discharge hematocrit and cell-depleted peripheral layer thickness. |
| first_indexed | 2024-12-11T17:45:13Z |
| format | Article |
| id | doaj.art-fbab2099acfb4c0fa3c31507e6269264 |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-12-11T17:45:13Z |
| publishDate | 2012-02-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-fbab2099acfb4c0fa3c31507e62692642022-12-22T00:56:25ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632012-02-0171577110.1299/jbse.7.57jbseParallel Simulation of Cellular Flow in Microvessels Using a Particle MethodDavod ALIZADEHRAD0Yohsuke IMAI1Keita NAKAAKI2Takuji ISHIKAWA3Takami YAMAGUCHI4Department of Biomedical Engineering, Tohoku UniversityDepartment of Bioengineering and Robotics, Tohoku UniversityDepartment of Bioengineering and Robotics, Tohoku UniversityDepartment of Bioengineering and Robotics, Tohoku UniversityDepartment of Biomedical Engineering, Tohoku UniversityWe developed a numerical method for large-scale simulations of cellular flow in microvessels. We employed a particle method, where all blood components were modeled using a finite number of particles. Red blood cell deformation was modeled by a spring network of membrane particles. A domain decomposition method was used for parallel implementation on distributed memory systems. In a strong scaling test up to 64 CPU cores, we obtained a linear speedup with the number of CPU cores, and demonstrated that our model can simulate O(103) red blood cells in vessels a few tens of micrometers in diameter. For quantitative validation, we analyzed the Fåhræus effect and the formation of a cell-depleted peripheral layer. Simulations were performed for tube hematocrit ranging from 20 to 45%, and microvessel diameters from 9 to 50 µm. Our numerical results were in good agreement with previous experimental results both for the discharge hematocrit and cell-depleted peripheral layer thickness.https://www.jstage.jst.go.jp/article/jbse/7/1/7_1_57/_pdf/-char/enlarge-scale simulationred blood cellmicrocirculationcell-depleted peripheral layerfåhræus effect |
| spellingShingle | Davod ALIZADEHRAD Yohsuke IMAI Keita NAKAAKI Takuji ISHIKAWA Takami YAMAGUCHI Parallel Simulation of Cellular Flow in Microvessels Using a Particle Method Journal of Biomechanical Science and Engineering large-scale simulation red blood cell microcirculation cell-depleted peripheral layer fåhræus effect |
| title | Parallel Simulation of Cellular Flow in Microvessels Using a Particle Method |
| title_full | Parallel Simulation of Cellular Flow in Microvessels Using a Particle Method |
| title_fullStr | Parallel Simulation of Cellular Flow in Microvessels Using a Particle Method |
| title_full_unstemmed | Parallel Simulation of Cellular Flow in Microvessels Using a Particle Method |
| title_short | Parallel Simulation of Cellular Flow in Microvessels Using a Particle Method |
| title_sort | parallel simulation of cellular flow in microvessels using a particle method |
| topic | large-scale simulation red blood cell microcirculation cell-depleted peripheral layer fåhræus effect |
| url | https://www.jstage.jst.go.jp/article/jbse/7/1/7_1_57/_pdf/-char/en |
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