Transactivation domain of Adenovirus Early Region 1A (E1A): Investigating folding dynamics and aggregation

Transactivation domain of Adenovirus Early Region 1A (E1A): Investigating folding dynamics and aggregation

Transactivation domain of Adenovirus Early region 1A (E1A) oncoprotein is an intrinsically disordered molecular hub protein. It is involved in binding to different domains of human cell transcriptional co-activators such as retinoblastoma (pRb), CREB-binding protein (CBP), and its paralogue p300. Th...

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Bibliographic Details
Main Authors: Nitin Sharma, Kundlik Gadhave, Prateek Kumar, Rajanish Giri
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Structural Biology
Subjects:
Intrinsically disordered proteins
Molecular recognition elements
E1A
Protein folding
Protein aggregation
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X22000010

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