Monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient: A preliminary report
Objective: Neoadjuvant chemotherapy was initially used in locally advanced breast cancer, and currently it is recommended for patients with Stage 3 and with early-stage disease with human epidermal growth factor receptors positive or triple-negative breast cancer. Ultrasound imaging in combination w...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-06-01
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| Series: | Journal of Ultrasonography |
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| Online Access: | http://www.jultrason.pl/index.php/issues/volume-19-no-77/monitoring-the-response-to-neoadjuvant-chemotherapy-in-patients-with-breast-cancer-using-ultrasound-scattering-coefficient-a-preliminary-report?aid=712 |
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| author | Katarzyna Dobruch-Sobczak Hanna Piotrzkowska-Wróblewska Ziemowit Klimoda Wojciech Secomski Piotr Karwat Ewa Markiewicz-Grodzicka Agnieszka Kolasińska-Ćwikła Katarzyna Roszkowska-Purska Jerzy Litniewski |
| author_facet | Katarzyna Dobruch-Sobczak Hanna Piotrzkowska-Wróblewska Ziemowit Klimoda Wojciech Secomski Piotr Karwat Ewa Markiewicz-Grodzicka Agnieszka Kolasińska-Ćwikła Katarzyna Roszkowska-Purska Jerzy Litniewski |
| author_sort | Katarzyna Dobruch-Sobczak |
| collection | DOAJ |
| description | Objective: Neoadjuvant chemotherapy was initially used in locally advanced breast cancer, and currently it is recommended for patients with Stage 3 and with early-stage disease with human epidermal growth factor receptors positive or triple-negative breast cancer. Ultrasound imaging in combination with a quantitative ultrasound method is a novel diagnostic approach. Aim of study: The aim of this study was to analyze the variability of the integrated backscatter coefficient, and to evaluate their use to predict the effectiveness of treatment and compare to ultrasound examination results. Material and method: Ten patients (mean age 52.9) with 13 breast tumors (mean dimension 41 mm) were selected for neoadjuvant chemotherapy. Ultrasound was performed before the treatment and one week after each course of neoadjuvant chemotherapy. The dimensions were assessed adopting the RECIST criteria. Tissue responses were classified as pathological response into the following categories: not responded to the treatment (G1, cell reduction by ≤9%) and responded to the treatment partially: G2, G3, G4, cell reduction by 10–29% (G2), 30–90% (G3), >90% (G4), respectively, and completely. Results: In B-mode examination partial response was observed in 9/13 cases (completely, G1, G3, G4), and stable disease was demonstrated in 3/13 cases (completely, G1, G4). Complete response was found in 1/13 cases. As for backscatter coefficient, 10/13 tumors (completely, and G2, G3, and G4) were characterized by an increased mean value of 153%. Three tumors 3/13 (G1) displayed a decreased mean value of 31%. Conclusion: The variability of backscatter coefficient, could be associated with alterations in the structure of the tumor tissue during neoadjuvant chemotherapy. There were unequivocal differences between responded and non-responded patients. The backscatter coefficient analysis correlated better with the results of histopathological verification than with the B-mode RECIST criteria. |
| first_indexed | 2024-12-11T18:57:23Z |
| format | Article |
| id | doaj.art-fbac398e30b24911a6c70938389cbc29 |
| institution | Directory Open Access Journal |
| issn | 2084-8404 2451-070X |
| language | English |
| last_indexed | 2024-12-11T18:57:23Z |
| publishDate | 2019-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Ultrasonography |
| spelling | doaj.art-fbac398e30b24911a6c70938389cbc292022-12-22T00:54:06ZengSciendoJournal of Ultrasonography2084-84042451-070X2019-06-011977899710.15557/JoU.2019.0013Monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient: A preliminary reportKatarzyna Dobruch-Sobczak0Hanna Piotrzkowska-Wróblewska1Ziemowit Klimoda2Wojciech Secomski3Piotr Karwat4Ewa Markiewicz-Grodzicka5 Agnieszka Kolasińska-Ćwikła6Katarzyna Roszkowska-Purska7Jerzy Litniewski8Ultrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland; Radiology Department, M. Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, PolandChemiotherapy Department, M. Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, PolandChemiotherapy Department, M. Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, PolandZakład Patomorfologii, M. Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, PolandObjective: Neoadjuvant chemotherapy was initially used in locally advanced breast cancer, and currently it is recommended for patients with Stage 3 and with early-stage disease with human epidermal growth factor receptors positive or triple-negative breast cancer. Ultrasound imaging in combination with a quantitative ultrasound method is a novel diagnostic approach. Aim of study: The aim of this study was to analyze the variability of the integrated backscatter coefficient, and to evaluate their use to predict the effectiveness of treatment and compare to ultrasound examination results. Material and method: Ten patients (mean age 52.9) with 13 breast tumors (mean dimension 41 mm) were selected for neoadjuvant chemotherapy. Ultrasound was performed before the treatment and one week after each course of neoadjuvant chemotherapy. The dimensions were assessed adopting the RECIST criteria. Tissue responses were classified as pathological response into the following categories: not responded to the treatment (G1, cell reduction by ≤9%) and responded to the treatment partially: G2, G3, G4, cell reduction by 10–29% (G2), 30–90% (G3), >90% (G4), respectively, and completely. Results: In B-mode examination partial response was observed in 9/13 cases (completely, G1, G3, G4), and stable disease was demonstrated in 3/13 cases (completely, G1, G4). Complete response was found in 1/13 cases. As for backscatter coefficient, 10/13 tumors (completely, and G2, G3, and G4) were characterized by an increased mean value of 153%. Three tumors 3/13 (G1) displayed a decreased mean value of 31%. Conclusion: The variability of backscatter coefficient, could be associated with alterations in the structure of the tumor tissue during neoadjuvant chemotherapy. There were unequivocal differences between responded and non-responded patients. The backscatter coefficient analysis correlated better with the results of histopathological verification than with the B-mode RECIST criteria.http://www.jultrason.pl/index.php/issues/volume-19-no-77/monitoring-the-response-to-neoadjuvant-chemotherapy-in-patients-with-breast-cancer-using-ultrasound-scattering-coefficient-a-preliminary-report?aid=712integrated backscatter coefficient (ibscs)neoadjuvant chemotherapy (nac)breast cancerultrasound |
| spellingShingle | Katarzyna Dobruch-Sobczak Hanna Piotrzkowska-Wróblewska Ziemowit Klimoda Wojciech Secomski Piotr Karwat Ewa Markiewicz-Grodzicka Agnieszka Kolasińska-Ćwikła Katarzyna Roszkowska-Purska Jerzy Litniewski Monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient: A preliminary report Journal of Ultrasonography integrated backscatter coefficient (ibscs) neoadjuvant chemotherapy (nac) breast cancer ultrasound |
| title | Monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient: A preliminary report |
| title_full | Monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient: A preliminary report |
| title_fullStr | Monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient: A preliminary report |
| title_full_unstemmed | Monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient: A preliminary report |
| title_short | Monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient: A preliminary report |
| title_sort | monitoring the response to neoadjuvant chemotherapy in patients with breast cancer using ultrasound scattering coefficient a preliminary report |
| topic | integrated backscatter coefficient (ibscs) neoadjuvant chemotherapy (nac) breast cancer ultrasound |
| url | http://www.jultrason.pl/index.php/issues/volume-19-no-77/monitoring-the-response-to-neoadjuvant-chemotherapy-in-patients-with-breast-cancer-using-ultrasound-scattering-coefficient-a-preliminary-report?aid=712 |
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