Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice

Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice

IntroductionIn this study, we report a novel therapeutic approach using B lymphocytes to attract islet-specific T cells in the non-obese diabetic (NOD) mouse model and prevent the development of autoimmune diabetes. Rather than using the antibody receptor of B cells, this approach utilizes their pro...

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Bibliographic Details
Main Authors: Dawei Chen, Dimitri Kakabadse, Sigal Fishman, Hadas Weinstein-Marom, Joanne Davies, Joanne Boldison, Terri C. Thayer, Li Wen, Gideon Gross, F. Susan Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
NOD mice
regulatory B cells
CD4+ T cells
CD8+ T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1227133/full

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