Risk factors for intubation and mortality in patients treated with high flow nasal cannula due to COVID-19 infection. Survival Analysis Study in a Northern Mexican Population.
<h4>Background</h4>COVID-19-related acute hypoxic respiratory failure patients often use high-flow nasal cannula (HFNO) oxygen therapy. COVID-19 HFNO intubation and mortality risk factors are understudied in the Mexican population, so the aim was to study them.<h4>Methods</h4>...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296931&type=printable |
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| author | José Antonio Luviano-García Alejandro Loose-Esparza Yodira Guadalupe Hernández-Ruíz Miguel Ángel Sanz-Sánchez Hector Jeovanny Maheda-García Miguel Angel Sosa-Medellin Arnulfo Garza-Silva Maria Elena Romero-Ibarguengoitia |
| author_facet | José Antonio Luviano-García Alejandro Loose-Esparza Yodira Guadalupe Hernández-Ruíz Miguel Ángel Sanz-Sánchez Hector Jeovanny Maheda-García Miguel Angel Sosa-Medellin Arnulfo Garza-Silva Maria Elena Romero-Ibarguengoitia |
| author_sort | José Antonio Luviano-García |
| collection | DOAJ |
| description | <h4>Background</h4>COVID-19-related acute hypoxic respiratory failure patients often use high-flow nasal cannula (HFNO) oxygen therapy. COVID-19 HFNO intubation and mortality risk factors are understudied in the Mexican population, so the aim was to study them.<h4>Methods</h4>This retrospective study searched electronic medical records from March 2020 to June 2022 for patients with COVID-19 who required hospitalization and HFNO. Descriptive statistics, a survival curve analysis, and Cox proportional hazard models were used to determine predictor factors for intubation and mortality in patients with HFNO and COVID-19, respectively.<h4>Results</h4>A total of 134 patients received HFNO treatment. Ninety-one (67.9%) were men with a mean (SD) age of 54.5 (17.9) years. Common medical history included obesity (n = 89, 66.4%) with a Body Mass Index (BMI) mean (SD) of 31.8 (5.9), hypertension (n = 67, 50.0%), type 2 diabetes (n = 55, 41.0%), and dyslipidemias (n = 43, 32.1%). The variables associated with a greater risk of requiring intubation after high-flow therapy were age (HR = 1.018, 95% CI 1.003-1.034, p = 0.022) and BMI (HR = 1.071, 95% CI 1.024-1.120, p = 0.003). No variables were associated with lower risk. Increased mortality was associated with increasing age (HR = 1.151, 95% CI 1.102-1.201, p = <0.001), hypertension (HR = 4.092, 95% CI 1.369-12.236, p = 0.012), and dyslipidemia (HR = 3.954, 95% CI 1.395-11.209, p = 0.010). Patients with type 2 diabetes had a lower risk of mortality (HR = 0.235, 95% CI 0.080-0.688, p = 0.008).<h4>Conclusions</h4>A higher age and BMI were associated with an increased risk of intubation in patients with HFNO and COVID-19. Hypertension and dyslipidemias were associated with a higher risk of mortality. |
| first_indexed | 2024-04-24T20:27:32Z |
| format | Article |
| id | doaj.art-fbadccda05974bd9a13249b71408db43 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-24T20:27:32Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fbadccda05974bd9a13249b71408db432024-03-22T05:31:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01193e029693110.1371/journal.pone.0296931Risk factors for intubation and mortality in patients treated with high flow nasal cannula due to COVID-19 infection. Survival Analysis Study in a Northern Mexican Population.José Antonio Luviano-GarcíaAlejandro Loose-EsparzaYodira Guadalupe Hernández-RuízMiguel Ángel Sanz-SánchezHector Jeovanny Maheda-GarcíaMiguel Angel Sosa-MedellinArnulfo Garza-SilvaMaria Elena Romero-Ibarguengoitia<h4>Background</h4>COVID-19-related acute hypoxic respiratory failure patients often use high-flow nasal cannula (HFNO) oxygen therapy. COVID-19 HFNO intubation and mortality risk factors are understudied in the Mexican population, so the aim was to study them.<h4>Methods</h4>This retrospective study searched electronic medical records from March 2020 to June 2022 for patients with COVID-19 who required hospitalization and HFNO. Descriptive statistics, a survival curve analysis, and Cox proportional hazard models were used to determine predictor factors for intubation and mortality in patients with HFNO and COVID-19, respectively.<h4>Results</h4>A total of 134 patients received HFNO treatment. Ninety-one (67.9%) were men with a mean (SD) age of 54.5 (17.9) years. Common medical history included obesity (n = 89, 66.4%) with a Body Mass Index (BMI) mean (SD) of 31.8 (5.9), hypertension (n = 67, 50.0%), type 2 diabetes (n = 55, 41.0%), and dyslipidemias (n = 43, 32.1%). The variables associated with a greater risk of requiring intubation after high-flow therapy were age (HR = 1.018, 95% CI 1.003-1.034, p = 0.022) and BMI (HR = 1.071, 95% CI 1.024-1.120, p = 0.003). No variables were associated with lower risk. Increased mortality was associated with increasing age (HR = 1.151, 95% CI 1.102-1.201, p = <0.001), hypertension (HR = 4.092, 95% CI 1.369-12.236, p = 0.012), and dyslipidemia (HR = 3.954, 95% CI 1.395-11.209, p = 0.010). Patients with type 2 diabetes had a lower risk of mortality (HR = 0.235, 95% CI 0.080-0.688, p = 0.008).<h4>Conclusions</h4>A higher age and BMI were associated with an increased risk of intubation in patients with HFNO and COVID-19. Hypertension and dyslipidemias were associated with a higher risk of mortality.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296931&type=printable |
| spellingShingle | José Antonio Luviano-García Alejandro Loose-Esparza Yodira Guadalupe Hernández-Ruíz Miguel Ángel Sanz-Sánchez Hector Jeovanny Maheda-García Miguel Angel Sosa-Medellin Arnulfo Garza-Silva Maria Elena Romero-Ibarguengoitia Risk factors for intubation and mortality in patients treated with high flow nasal cannula due to COVID-19 infection. Survival Analysis Study in a Northern Mexican Population. PLoS ONE |
| title | Risk factors for intubation and mortality in patients treated with high flow nasal cannula due to COVID-19 infection. Survival Analysis Study in a Northern Mexican Population. |
| title_full | Risk factors for intubation and mortality in patients treated with high flow nasal cannula due to COVID-19 infection. Survival Analysis Study in a Northern Mexican Population. |
| title_fullStr | Risk factors for intubation and mortality in patients treated with high flow nasal cannula due to COVID-19 infection. Survival Analysis Study in a Northern Mexican Population. |
| title_full_unstemmed | Risk factors for intubation and mortality in patients treated with high flow nasal cannula due to COVID-19 infection. Survival Analysis Study in a Northern Mexican Population. |
| title_short | Risk factors for intubation and mortality in patients treated with high flow nasal cannula due to COVID-19 infection. Survival Analysis Study in a Northern Mexican Population. |
| title_sort | risk factors for intubation and mortality in patients treated with high flow nasal cannula due to covid 19 infection survival analysis study in a northern mexican population |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296931&type=printable |
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