Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancer
Background Peak oxygen uptake (V˙O2peak) measured by a cardiopulmonary exercise test (CPX) is the gold‐standard for predicting surgical risk in patients with non‐small cell lung cancer (NSCLC). The 3‐minute chair rise test (3CRT) is a simple test requiring minimal resources. This study aimed to dete...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-09-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.13548 |
| _version_ | 1818267797153644544 |
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| author | Mathilde Azzi David Debeaumont Tristan Bonnevie Bernard Aguilaniu Damiano Cerasuolo Fairuz Boujibar Antoine Cuvelier Francis‐Edouard Gravier |
| author_facet | Mathilde Azzi David Debeaumont Tristan Bonnevie Bernard Aguilaniu Damiano Cerasuolo Fairuz Boujibar Antoine Cuvelier Francis‐Edouard Gravier |
| author_sort | Mathilde Azzi |
| collection | DOAJ |
| description | Background Peak oxygen uptake (V˙O2peak) measured by a cardiopulmonary exercise test (CPX) is the gold‐standard for predicting surgical risk in patients with non‐small cell lung cancer (NSCLC). The 3‐minute chair rise test (3CRT) is a simple test requiring minimal resources. This study aimed to determine the ability of 3CRT to predict V˙O2peak in patients with NSCLC. Methods Retrospective data from CPX and 3CRT carried out in 36 patients with NSCLC between March 2018 and February 2019 were included. A multivariate analysis was undertaken to derive a predictive V˙O2peak equation based on performance on the 3CRT. In addition, sensitivity‐specificity analysis was carried out to estimate a threshold 3CRT value for the prediction of V˙O2peak ≥ 15 mL/kg/minute. Results The following equation was obtained: V˙O2peak predicted = (0.04765 × FEV1) ‐ (0.207 59 × BMI) ‐ (0.115 89 × age) + (0.386 09 × vertical distance) + 16.628 69; r2 = 0.75, P < 0.01. The bias between the V˙O2peak values predicted and measured during CPX was 0.0 ± 1.7 mL/kg/minute (95% limits of agreement [−3.5 to 3.5]). A performance ≥49 chair rises predicted V˙O2peak ≥ 15 mL/kg/minute with a sensitivity of 0.75 and a specificity of 0.81. Conclusions The level of error in the prediction of V˙O2peak from 3CRT performance was too great to recommend that 3CRT should replace CPX as the sole measurement of V˙O2peak. Nevertheless, the 3CRT could help to identify those patients that require CPX prior to lung resection surgery for NSCLC, larger prospective study is needed to confirm this hypothesis. Key points Significant findings of the study Cardiopulmonary exercise tests can stratify the surgical risk. Prediction of the peak oxygen uptake (V˙O2peak) value from the 3CRT yields an unacceptable level of error. However, a performance of 49 chair rises or more during the 3CRT could indicate a V˙O2peak ≥ 15 mL / kg / minute. What this study adds The 3CRT is a useful screening tool to determine the necessity for a comprehensive cardiopulmonary exercise test, whose access is limited in clinical practice. It could also allow early screening of patients requiring specific prehabilitation programs. |
| first_indexed | 2024-12-12T20:28:18Z |
| format | Article |
| id | doaj.art-fbadd30ea6724a96a9e1f3e261e3e1fa |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-12-12T20:28:18Z |
| publishDate | 2020-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-fbadd30ea6724a96a9e1f3e261e3e1fa2022-12-22T00:13:06ZengWileyThoracic Cancer1759-77061759-77142020-09-011192431243910.1111/1759-7714.13548Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancerMathilde Azzi0David Debeaumont1Tristan Bonnevie2Bernard Aguilaniu3Damiano Cerasuolo4Fairuz Boujibar5Antoine Cuvelier6Francis‐Edouard Gravier7Department of Respiratory and Exercise Physiology Rouen University Hospital Rouen FranceDepartment of Respiratory and Exercise Physiology Rouen University Hospital Rouen FranceADIR Association, Rouen University Hospital Rouen FranceFaculty of Medicine Grenoble‐Alpes University Grenoble FranceDepartment of Biostatistics Rouen University Hospital Rouen FranceNormandy University UNIROUEN, INSERM U1096, Haute Normandie Research and Biomedical Innovation Rouen FrancePulmonary, Thoracic Oncology and Respiratory Intensive Care Department Rouen University Hospital Rouen FranceADIR Association, Rouen University Hospital Rouen FranceBackground Peak oxygen uptake (V˙O2peak) measured by a cardiopulmonary exercise test (CPX) is the gold‐standard for predicting surgical risk in patients with non‐small cell lung cancer (NSCLC). The 3‐minute chair rise test (3CRT) is a simple test requiring minimal resources. This study aimed to determine the ability of 3CRT to predict V˙O2peak in patients with NSCLC. Methods Retrospective data from CPX and 3CRT carried out in 36 patients with NSCLC between March 2018 and February 2019 were included. A multivariate analysis was undertaken to derive a predictive V˙O2peak equation based on performance on the 3CRT. In addition, sensitivity‐specificity analysis was carried out to estimate a threshold 3CRT value for the prediction of V˙O2peak ≥ 15 mL/kg/minute. Results The following equation was obtained: V˙O2peak predicted = (0.04765 × FEV1) ‐ (0.207 59 × BMI) ‐ (0.115 89 × age) + (0.386 09 × vertical distance) + 16.628 69; r2 = 0.75, P < 0.01. The bias between the V˙O2peak values predicted and measured during CPX was 0.0 ± 1.7 mL/kg/minute (95% limits of agreement [−3.5 to 3.5]). A performance ≥49 chair rises predicted V˙O2peak ≥ 15 mL/kg/minute with a sensitivity of 0.75 and a specificity of 0.81. Conclusions The level of error in the prediction of V˙O2peak from 3CRT performance was too great to recommend that 3CRT should replace CPX as the sole measurement of V˙O2peak. Nevertheless, the 3CRT could help to identify those patients that require CPX prior to lung resection surgery for NSCLC, larger prospective study is needed to confirm this hypothesis. Key points Significant findings of the study Cardiopulmonary exercise tests can stratify the surgical risk. Prediction of the peak oxygen uptake (V˙O2peak) value from the 3CRT yields an unacceptable level of error. However, a performance of 49 chair rises or more during the 3CRT could indicate a V˙O2peak ≥ 15 mL / kg / minute. What this study adds The 3CRT is a useful screening tool to determine the necessity for a comprehensive cardiopulmonary exercise test, whose access is limited in clinical practice. It could also allow early screening of patients requiring specific prehabilitation programs.https://doi.org/10.1111/1759-7714.13548Cardiopulmonary exercise testingfield testlung surgerynon‐small cell lung cancerpreoperative assessment |
| spellingShingle | Mathilde Azzi David Debeaumont Tristan Bonnevie Bernard Aguilaniu Damiano Cerasuolo Fairuz Boujibar Antoine Cuvelier Francis‐Edouard Gravier Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancer Thoracic Cancer Cardiopulmonary exercise testing field test lung surgery non‐small cell lung cancer preoperative assessment |
| title | Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancer |
| title_full | Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancer |
| title_fullStr | Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancer |
| title_full_unstemmed | Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancer |
| title_short | Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancer |
| title_sort | evaluation of the 3 minute chair rise test as part of preoperative evaluation for patients with non small cell lung cancer |
| topic | Cardiopulmonary exercise testing field test lung surgery non‐small cell lung cancer preoperative assessment |
| url | https://doi.org/10.1111/1759-7714.13548 |
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