Impact of the Treatment of <i>Serenoa repens</i>, <i>Solanum lycopersicum</i>, <i>Lycopene</i> and <i>Bromelain</i> in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis
Background: Phytotherapeutic agents aroused an increasing interest either as alternative or in addition to conventional therapy in the management of BPH. The aim of the article was to evaluate the clinical and functional changes after add-on treatment with <i>Serenoa repens</i> associate...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Uro |
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| Online Access: | https://www.mdpi.com/2673-4397/1/4/25 |
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| author | Luca Lambertini Fabrizio Di Maida Riccardo Tellini Claudio Bisegna Francesca Valastro Antonio Andrea Grosso Sabino Scelzi Francesco Del Giudice Matteo Ferro Giacomo Maria Pirola Marilena Gubbiotti Lorenzo Masieri Gian Maria Busetto Ottavio de Cobelli Andrea Minervini Andrea Mari |
| author_facet | Luca Lambertini Fabrizio Di Maida Riccardo Tellini Claudio Bisegna Francesca Valastro Antonio Andrea Grosso Sabino Scelzi Francesco Del Giudice Matteo Ferro Giacomo Maria Pirola Marilena Gubbiotti Lorenzo Masieri Gian Maria Busetto Ottavio de Cobelli Andrea Minervini Andrea Mari |
| author_sort | Luca Lambertini |
| collection | DOAJ |
| description | Background: Phytotherapeutic agents aroused an increasing interest either as alternative or in addition to conventional therapy in the management of BPH. The aim of the article was to evaluate the clinical and functional changes after add-on treatment with <i>Serenoa repens</i> associated with <i>Solanum lycopersicum</i>, <i>lycopene</i> and <i>bromelain</i> in patients with BPH presenting with mild to moderate LUTS and previously treated only with Alfuzosin over a 6–12 months period. Materials and methods: Between January and July 2019, patients with symptomatic BPH already on treatment with Alfuzosin (Al) 10 mg for at least 6–12-month were enrolled at three academic referral centres, included in a prospective treatment group, and managed with a combination treatment of Al and 6-month daily oral single-tablet supplementation of <i>Serenoa repens</i> and <i>Solanum lycopersicum</i> + <i>lycopene</i> + <i>bromelain</i> (SeR + SL + Ly + Br). A retrospective control group with comparable baseline characteristics was obtained by performing a propensity score matching from a database of 434 patients managed with Alfuzosin 10 mg/day only over a 6–12 months period between March 2015 and December 2018. IPSS, QoL questionnaires, voiding diary assessment, postvoid residual volume (PVR), maximal (Qmax) and average (Qave) urinary flow rates were evaluated at baseline in the treatment group at the moment of patient accrual, in the control group after 6-month of treatment with alfuzosin, and thereafter at 3 and 6 months in both groups. Results: Overall, 250 patients entered the study (<i>n</i> = 125 treatment group; <i>n</i> = 125 control group). Total IPSS score significantly decreased at 6-month assessment from baseline in the treatment vs control group (17 [IQR: 12–20] vs 12 [IQR: 9–14], <i>p</i> = 0.02) with a significative storage symptoms improvement detected both at 3- (<i>p</i> = 0.03) and 6-month evaluation (<i>p</i> = 0.001). PVR significantly improved at each follow-up visit with the most relevant reduction at 6-month assessment (125 cc vs. 102 cc; <i>p</i> = 0.02). Moreover, a significative improvement in LUTS-related quality of life (QoL) was recorded at 3- and 6-month assessment with a median decrease of −1 and −2 (<i>p</i> = 0.05 and <i>p</i> = 0.001 respectively) from baseline. Conclusions: Combination treatment with AB and SeR + SL + Ly + Br led to meaningful improvements in LUTS severity compared to AB as monotherapy, after a 6-month treatment period in men with mild to moderate LUTS/BPH. |
| first_indexed | 2024-03-10T03:57:37Z |
| format | Article |
| id | doaj.art-fbb046981c38400c996a0cd185f4eb18 |
| institution | Directory Open Access Journal |
| issn | 2673-4397 |
| language | English |
| last_indexed | 2024-03-10T03:57:37Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Uro |
| spelling | doaj.art-fbb046981c38400c996a0cd185f4eb182023-11-23T10:53:22ZengMDPI AGUro2673-43972021-11-011422823710.3390/uro1040025Impact of the Treatment of <i>Serenoa repens</i>, <i>Solanum lycopersicum</i>, <i>Lycopene</i> and <i>Bromelain</i> in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison AnalysisLuca Lambertini0Fabrizio Di Maida1Riccardo Tellini2Claudio Bisegna3Francesca Valastro4Antonio Andrea Grosso5Sabino Scelzi6Francesco Del Giudice7Matteo Ferro8Giacomo Maria Pirola9Marilena Gubbiotti10Lorenzo Masieri11Gian Maria Busetto12Ottavio de Cobelli13Andrea Minervini14Andrea Mari15Unit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyDepartment of Urology, Sapienza University of Rome, 00185 Rome, ItalyDivision of Urology, European Institute of Oncology, IRCCS, 20133 Milan, ItalyDepartment of Urology, San Donato Hospital, 52100 Arezzo, ItalyDepartment of Urology, San Donato Hospital, 52100 Arezzo, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyDepartment of Urology, Sapienza University of Rome, 00185 Rome, ItalyDivision of Urology, European Institute of Oncology, IRCCS, 20133 Milan, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyUnit of Urological Oncologic Minimally-Invasive Robotic Surgery and Andrology, Careggi Hospital, 50134 Florence, ItalyBackground: Phytotherapeutic agents aroused an increasing interest either as alternative or in addition to conventional therapy in the management of BPH. The aim of the article was to evaluate the clinical and functional changes after add-on treatment with <i>Serenoa repens</i> associated with <i>Solanum lycopersicum</i>, <i>lycopene</i> and <i>bromelain</i> in patients with BPH presenting with mild to moderate LUTS and previously treated only with Alfuzosin over a 6–12 months period. Materials and methods: Between January and July 2019, patients with symptomatic BPH already on treatment with Alfuzosin (Al) 10 mg for at least 6–12-month were enrolled at three academic referral centres, included in a prospective treatment group, and managed with a combination treatment of Al and 6-month daily oral single-tablet supplementation of <i>Serenoa repens</i> and <i>Solanum lycopersicum</i> + <i>lycopene</i> + <i>bromelain</i> (SeR + SL + Ly + Br). A retrospective control group with comparable baseline characteristics was obtained by performing a propensity score matching from a database of 434 patients managed with Alfuzosin 10 mg/day only over a 6–12 months period between March 2015 and December 2018. IPSS, QoL questionnaires, voiding diary assessment, postvoid residual volume (PVR), maximal (Qmax) and average (Qave) urinary flow rates were evaluated at baseline in the treatment group at the moment of patient accrual, in the control group after 6-month of treatment with alfuzosin, and thereafter at 3 and 6 months in both groups. Results: Overall, 250 patients entered the study (<i>n</i> = 125 treatment group; <i>n</i> = 125 control group). Total IPSS score significantly decreased at 6-month assessment from baseline in the treatment vs control group (17 [IQR: 12–20] vs 12 [IQR: 9–14], <i>p</i> = 0.02) with a significative storage symptoms improvement detected both at 3- (<i>p</i> = 0.03) and 6-month evaluation (<i>p</i> = 0.001). PVR significantly improved at each follow-up visit with the most relevant reduction at 6-month assessment (125 cc vs. 102 cc; <i>p</i> = 0.02). Moreover, a significative improvement in LUTS-related quality of life (QoL) was recorded at 3- and 6-month assessment with a median decrease of −1 and −2 (<i>p</i> = 0.05 and <i>p</i> = 0.001 respectively) from baseline. Conclusions: Combination treatment with AB and SeR + SL + Ly + Br led to meaningful improvements in LUTS severity compared to AB as monotherapy, after a 6-month treatment period in men with mild to moderate LUTS/BPH.https://www.mdpi.com/2673-4397/1/4/25benign prostate hyperplasiainflammationphytotherapy<i>Serenoa repens</i><i>Solanum lycopersicum</i><i>lycopene</i> |
| spellingShingle | Luca Lambertini Fabrizio Di Maida Riccardo Tellini Claudio Bisegna Francesca Valastro Antonio Andrea Grosso Sabino Scelzi Francesco Del Giudice Matteo Ferro Giacomo Maria Pirola Marilena Gubbiotti Lorenzo Masieri Gian Maria Busetto Ottavio de Cobelli Andrea Minervini Andrea Mari Impact of the Treatment of <i>Serenoa repens</i>, <i>Solanum lycopersicum</i>, <i>Lycopene</i> and <i>Bromelain</i> in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis Uro benign prostate hyperplasia inflammation phytotherapy <i>Serenoa repens</i> <i>Solanum lycopersicum</i> <i>lycopene</i> |
| title | Impact of the Treatment of <i>Serenoa repens</i>, <i>Solanum lycopersicum</i>, <i>Lycopene</i> and <i>Bromelain</i> in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis |
| title_full | Impact of the Treatment of <i>Serenoa repens</i>, <i>Solanum lycopersicum</i>, <i>Lycopene</i> and <i>Bromelain</i> in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis |
| title_fullStr | Impact of the Treatment of <i>Serenoa repens</i>, <i>Solanum lycopersicum</i>, <i>Lycopene</i> and <i>Bromelain</i> in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis |
| title_full_unstemmed | Impact of the Treatment of <i>Serenoa repens</i>, <i>Solanum lycopersicum</i>, <i>Lycopene</i> and <i>Bromelain</i> in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis |
| title_short | Impact of the Treatment of <i>Serenoa repens</i>, <i>Solanum lycopersicum</i>, <i>Lycopene</i> and <i>Bromelain</i> in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis |
| title_sort | impact of the treatment of i serenoa repens i i solanum lycopersicum i i lycopene i and i bromelain i in combination with alfuzosin for benign prostatic hyperplasia results from a match paired comparison analysis |
| topic | benign prostate hyperplasia inflammation phytotherapy <i>Serenoa repens</i> <i>Solanum lycopersicum</i> <i>lycopene</i> |
| url | https://www.mdpi.com/2673-4397/1/4/25 |
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