Clinical Evaluation of Oral Curcumin in Prevention of Acute
Background: Acute radiation induced dermatitis, has a history as long as breast radiotherapy. Although new techniques have reduced the onset of dermatitis in breast radiotherapy patients, no standard protocol exists for its prophylaxis. This study has evaluated “Curcumin” for prophylaxis of radiatio...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2011-10-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1110 |
| _version_ | 1797717373055139840 |
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| author | Simin Hemati Armin Saeedi |
| author_facet | Simin Hemati Armin Saeedi |
| author_sort | Simin Hemati |
| collection | DOAJ |
| description | Background: Acute radiation induced dermatitis, has a history as long as breast radiotherapy. Although new techniques have reduced the onset of dermatitis in breast radiotherapy patients, no standard protocol exists for its prophylaxis. This study has evaluated “Curcumin” for prophylaxis of radiation induced dermatitis.
Methods: 40 breast radiotherapy candidates randomly put in two equal groups, received oral capsules (four 500 mg capsules, 3 times a day) filled with Curcumin or Placebo from 2 days before to the last day of radiotherapy 6 weeks course. Dermatitis degree recorded in weekly visits.
Findings: A faster increasing in mean degree of dermatitis was seen in placebo group. The difference was statistically significant in last two weeks of radiotherapy. No considerable side effect was reported. Patients’ age, type of surgery, hormone receptor and HER2/neu status, did not affect curcumin group superiority in degree of radiation induced dermatitis.
Conclusion: Oral curcumin is effective in prophylaxis of radiation induced dermatitis in breast cancer
radiation. |
| first_indexed | 2024-03-12T08:36:22Z |
| format | Article |
| id | doaj.art-fbb12c4f32e344d88e24450a87b0794a |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:36:22Z |
| publishDate | 2011-10-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-fbb12c4f32e344d88e24450a87b0794a2023-09-02T17:18:04ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2011-10-012915212161223743Clinical Evaluation of Oral Curcumin in Prevention of AcuteSimin Hemati0Armin Saeedi1Assistant Professor, Department of Radiation Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranResident, Department of Radiation Oncology, School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranBackground: Acute radiation induced dermatitis, has a history as long as breast radiotherapy. Although new techniques have reduced the onset of dermatitis in breast radiotherapy patients, no standard protocol exists for its prophylaxis. This study has evaluated “Curcumin” for prophylaxis of radiation induced dermatitis. Methods: 40 breast radiotherapy candidates randomly put in two equal groups, received oral capsules (four 500 mg capsules, 3 times a day) filled with Curcumin or Placebo from 2 days before to the last day of radiotherapy 6 weeks course. Dermatitis degree recorded in weekly visits. Findings: A faster increasing in mean degree of dermatitis was seen in placebo group. The difference was statistically significant in last two weeks of radiotherapy. No considerable side effect was reported. Patients’ age, type of surgery, hormone receptor and HER2/neu status, did not affect curcumin group superiority in degree of radiation induced dermatitis. Conclusion: Oral curcumin is effective in prophylaxis of radiation induced dermatitis in breast cancer radiation.http://jims.mui.ac.ir/index.php/jims/article/view/1110Breast cancerRadiotherapyDermatitisCurcumin. |
| spellingShingle | Simin Hemati Armin Saeedi Clinical Evaluation of Oral Curcumin in Prevention of Acute مجله دانشکده پزشکی اصفهان Breast cancer Radiotherapy Dermatitis Curcumin. |
| title | Clinical Evaluation of Oral Curcumin in Prevention of Acute |
| title_full | Clinical Evaluation of Oral Curcumin in Prevention of Acute |
| title_fullStr | Clinical Evaluation of Oral Curcumin in Prevention of Acute |
| title_full_unstemmed | Clinical Evaluation of Oral Curcumin in Prevention of Acute |
| title_short | Clinical Evaluation of Oral Curcumin in Prevention of Acute |
| title_sort | clinical evaluation of oral curcumin in prevention of acute |
| topic | Breast cancer Radiotherapy Dermatitis Curcumin. |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/1110 |
| work_keys_str_mv | AT siminhemati clinicalevaluationoforalcurcumininpreventionofacute AT arminsaeedi clinicalevaluationoforalcurcumininpreventionofacute |