Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study
Abstract Low‐grade inflammation is central to coronary artery disease (CAD) and type 2 diabetes (T2D) and is reduced by exercise training. The objective of this study was to compare the anti‐inflammatory potential of moderate‐to‐vigorous intensity continuous training (MICT) and high‐intensity interv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15634 |
| _version_ | 1797397387082203136 |
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| author | Léa Garneau Tasuku Terada Matheus Mistura Erin E. Mulvihill Jennifer L. Reed Céline Aguer |
| author_facet | Léa Garneau Tasuku Terada Matheus Mistura Erin E. Mulvihill Jennifer L. Reed Céline Aguer |
| author_sort | Léa Garneau |
| collection | DOAJ |
| description | Abstract Low‐grade inflammation is central to coronary artery disease (CAD) and type 2 diabetes (T2D) and is reduced by exercise training. The objective of this study was to compare the anti‐inflammatory potential of moderate‐to‐vigorous intensity continuous training (MICT) and high‐intensity interval training (HIIT) in patients with CAD with or without T2D. The design and setting of this study is based on a secondary analysis of registered randomized clinical trial NCT02765568. Male patients with CAD were randomly assigned to either MICT or HIIT, with subgroups divided according to T2D status (non‐T2D‐HIIT n = 14 and non‐T2D‐MICT n = 13; T2D‐HIIT n = 6 and T2D‐MICT n = 5). The intervention was a 12‐week cardiovascular rehabilitation program consisting of either MICT or HIIT (twice weekly sessions) and circulating cytokines measured pre‐ and post‐training as inflammatory markers. The co‐occurrence of CAD and T2D was associated with increased plasma IL‐8 (p = 0.0331). There was an interaction between T2D and the effect of the training interventions on plasma FGF21 (p = 0.0368) and IL‐6 (p = 0.0385), which were further reduced in the T2D groups. An interaction between T2D, training modalities, and the effect of time (p = 0.0415) was detected for SPARC, with HIIT increasing circulating concentrations in the control group, while lowering them in the T2D group, and the inverse occurring with MICT. The interventions also reduced plasma FGF21 (p = 0.0030), IL‐6 (p = 0.0101), IL‐8 (p = 0.0087), IL‐10 (p < 0.0001), and IL‐18 (p = 0.0009) irrespective of training modality or T2D status. HIIT and MICT resulted in similar reductions in circulating cytokines known to be increased in the context of low‐grade inflammation in CAD patients, an effect more pronounced in patients with T2D for FGF21 and IL‐6. |
| first_indexed | 2024-03-09T01:09:10Z |
| format | Article |
| id | doaj.art-fbb1a14260aa41019a69657a5a6c5bfa |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-09T01:09:10Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-fbb1a14260aa41019a69657a5a6c5bfa2023-12-11T08:18:31ZengWileyPhysiological Reports2051-817X2023-03-01115n/an/a10.14814/phy2.15634Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot studyLéa Garneau0Tasuku Terada1Matheus Mistura2Erin E. Mulvihill3Jennifer L. Reed4Céline Aguer5Institut du Savoir Montfort – Recherche Ontario Ottawa CanadaExercise Physiology and Cardiovascular Health Lab University of Ottawa Heart Institute Ottawa Ontario CanadaExercise Physiology and Cardiovascular Health Lab University of Ottawa Heart Institute Ottawa Ontario CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine University of Ottawa Ottawa Ontario CanadaExercise Physiology and Cardiovascular Health Lab University of Ottawa Heart Institute Ottawa Ontario CanadaInstitut du Savoir Montfort – Recherche Ontario Ottawa CanadaAbstract Low‐grade inflammation is central to coronary artery disease (CAD) and type 2 diabetes (T2D) and is reduced by exercise training. The objective of this study was to compare the anti‐inflammatory potential of moderate‐to‐vigorous intensity continuous training (MICT) and high‐intensity interval training (HIIT) in patients with CAD with or without T2D. The design and setting of this study is based on a secondary analysis of registered randomized clinical trial NCT02765568. Male patients with CAD were randomly assigned to either MICT or HIIT, with subgroups divided according to T2D status (non‐T2D‐HIIT n = 14 and non‐T2D‐MICT n = 13; T2D‐HIIT n = 6 and T2D‐MICT n = 5). The intervention was a 12‐week cardiovascular rehabilitation program consisting of either MICT or HIIT (twice weekly sessions) and circulating cytokines measured pre‐ and post‐training as inflammatory markers. The co‐occurrence of CAD and T2D was associated with increased plasma IL‐8 (p = 0.0331). There was an interaction between T2D and the effect of the training interventions on plasma FGF21 (p = 0.0368) and IL‐6 (p = 0.0385), which were further reduced in the T2D groups. An interaction between T2D, training modalities, and the effect of time (p = 0.0415) was detected for SPARC, with HIIT increasing circulating concentrations in the control group, while lowering them in the T2D group, and the inverse occurring with MICT. The interventions also reduced plasma FGF21 (p = 0.0030), IL‐6 (p = 0.0101), IL‐8 (p = 0.0087), IL‐10 (p < 0.0001), and IL‐18 (p = 0.0009) irrespective of training modality or T2D status. HIIT and MICT resulted in similar reductions in circulating cytokines known to be increased in the context of low‐grade inflammation in CAD patients, an effect more pronounced in patients with T2D for FGF21 and IL‐6.https://doi.org/10.14814/phy2.15634coronary artery diseasecytokinesexerciseinterleukinstype 2 diabetes |
| spellingShingle | Léa Garneau Tasuku Terada Matheus Mistura Erin E. Mulvihill Jennifer L. Reed Céline Aguer Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study Physiological Reports coronary artery disease cytokines exercise interleukins type 2 diabetes |
| title | Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study |
| title_full | Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study |
| title_fullStr | Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study |
| title_full_unstemmed | Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study |
| title_short | Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study |
| title_sort | exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes a pilot study |
| topic | coronary artery disease cytokines exercise interleukins type 2 diabetes |
| url | https://doi.org/10.14814/phy2.15634 |
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