Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility

Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility

The increase in presynaptic striatal dopamine is the main dopaminergic abnormality in schizophrenia (SCZ). SCZ is primarily treated by modulating the activity of monoamine systems, with a focus on dopamine and serotonin receptors. Glial cell line-derived neurotrophic factor (GDNF) is a strong dopami...

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Bibliographic Details
Main Authors: Laoise Casserly, Daniel R. Garton, Ana Montaño-Rodriguez, Jaan-Olle Andressoo
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomolecules
Subjects:
schizophrenia
dopamine
GDNF
GFRa1
RET
monoamines
Online Access:https://www.mdpi.com/2218-273X/13/9/1428

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