Blockage of mechanosensitive Piezo1 channel alleviates the severity of experimental malaria-associated acute lung injury

Blockage of mechanosensitive Piezo1 channel alleviates the severity of experimental malaria-associated acute lung injury

Abstract Background Malaria-associated acute lung injury (MA-ALI) is a well-recognized clinical complication of severe, complicated malaria that is partly driven by sequestrations of infected red blood cells (iRBCs) on lung postcapillary induced impaired blood flow. In earlier studies the mechanosen...

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Bibliographic Details
Main Authors: Min Zhang, Qian Ru Wang, Xinpeng Hou, Qi Wang, Xiaoyan Yang, Tingting Zhou, Xiaobo Liu, Lirong Wu, Jie Wang, Xiaobao Jin, Zhenlong Liu, Bo Huang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Parasites & Vectors
Subjects:
Malaria
Acute lung injury
Piezo1
Macrophage polarization
Ferroptosis
Online Access:https://doi.org/10.1186/s13071-024-06144-5

Internet

https://doi.org/10.1186/s13071-024-06144-5

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