Antimicrobial Resistance in Commensal <i>Escherichia coli</i> of the Porcine Gastrointestinal Tract
Antimicrobial resistance (AMR) in <i>Escherichia coli</i> of animal origin presents a threat to human health. Although animals are not the primary source of human infections, humans may be exposed to AMR <i>E. coli</i> of animal origin and their AMR genes through the food cha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/11/1616 |
| _version_ | 1797460438399582208 |
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| author | Lorcan O’Neill Edgar García Manzanilla Daniel Ekhlas Finola C. Leonard |
| author_facet | Lorcan O’Neill Edgar García Manzanilla Daniel Ekhlas Finola C. Leonard |
| author_sort | Lorcan O’Neill |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) in <i>Escherichia coli</i> of animal origin presents a threat to human health. Although animals are not the primary source of human infections, humans may be exposed to AMR <i>E. coli</i> of animal origin and their AMR genes through the food chain, direct contact with animals, and via the environment. For this reason, AMR in <i>E. coli</i> from food producing animals is included in most national and international AMR monitoring programmes and is the subject of a large body of research. As pig farming is one of the largest livestock sectors and the one with the highest antimicrobial use, there is considerable interest in the epidemiology of AMR in <i>E. coli</i> of porcine origin. This literature review presents an overview and appraisal of current knowledge of AMR in commensal <i>E. coli</i> of the porcine gastrointestinal tract with a focus on its evolution during the pig lifecycle and the relationship with antimicrobial use. It also presents an overview of the epidemiology of resistance to extended spectrum cephalosporins, fluoroquinolones, and colistin in pig production. The review highlights the widespread nature of AMR in the porcine commensal <i>E. coli</i> population, especially to the most-used classes in pig farming and discusses the complex interplay between age and antimicrobial use during the pig lifecycle. |
| first_indexed | 2024-03-09T17:05:03Z |
| format | Article |
| id | doaj.art-fbb3b07c2c69473198d236c616b87c05 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T17:05:03Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-fbb3b07c2c69473198d236c616b87c052023-11-24T14:25:21ZengMDPI AGAntibiotics2079-63822023-11-011211161610.3390/antibiotics12111616Antimicrobial Resistance in Commensal <i>Escherichia coli</i> of the Porcine Gastrointestinal TractLorcan O’Neill0Edgar García Manzanilla1Daniel Ekhlas2Finola C. Leonard3Pig Development Department, Teagasc, The Irish Food and Agriculture Authority, Moorepark, Fermoy, Co Cork P61 C996, IrelandPig Development Department, Teagasc, The Irish Food and Agriculture Authority, Moorepark, Fermoy, Co Cork P61 C996, IrelandPig Development Department, Teagasc, The Irish Food and Agriculture Authority, Moorepark, Fermoy, Co Cork P61 C996, IrelandSchool of Veterinary Medicine, University College Dublin, Belfield, Dublin D04 V1W8, IrelandAntimicrobial resistance (AMR) in <i>Escherichia coli</i> of animal origin presents a threat to human health. Although animals are not the primary source of human infections, humans may be exposed to AMR <i>E. coli</i> of animal origin and their AMR genes through the food chain, direct contact with animals, and via the environment. For this reason, AMR in <i>E. coli</i> from food producing animals is included in most national and international AMR monitoring programmes and is the subject of a large body of research. As pig farming is one of the largest livestock sectors and the one with the highest antimicrobial use, there is considerable interest in the epidemiology of AMR in <i>E. coli</i> of porcine origin. This literature review presents an overview and appraisal of current knowledge of AMR in commensal <i>E. coli</i> of the porcine gastrointestinal tract with a focus on its evolution during the pig lifecycle and the relationship with antimicrobial use. It also presents an overview of the epidemiology of resistance to extended spectrum cephalosporins, fluoroquinolones, and colistin in pig production. The review highlights the widespread nature of AMR in the porcine commensal <i>E. coli</i> population, especially to the most-used classes in pig farming and discusses the complex interplay between age and antimicrobial use during the pig lifecycle.https://www.mdpi.com/2079-6382/12/11/1616antimicrobial resistance<i>Escherichia coli</i>commensalpigs |
| spellingShingle | Lorcan O’Neill Edgar García Manzanilla Daniel Ekhlas Finola C. Leonard Antimicrobial Resistance in Commensal <i>Escherichia coli</i> of the Porcine Gastrointestinal Tract Antibiotics antimicrobial resistance <i>Escherichia coli</i> commensal pigs |
| title | Antimicrobial Resistance in Commensal <i>Escherichia coli</i> of the Porcine Gastrointestinal Tract |
| title_full | Antimicrobial Resistance in Commensal <i>Escherichia coli</i> of the Porcine Gastrointestinal Tract |
| title_fullStr | Antimicrobial Resistance in Commensal <i>Escherichia coli</i> of the Porcine Gastrointestinal Tract |
| title_full_unstemmed | Antimicrobial Resistance in Commensal <i>Escherichia coli</i> of the Porcine Gastrointestinal Tract |
| title_short | Antimicrobial Resistance in Commensal <i>Escherichia coli</i> of the Porcine Gastrointestinal Tract |
| title_sort | antimicrobial resistance in commensal i escherichia coli i of the porcine gastrointestinal tract |
| topic | antimicrobial resistance <i>Escherichia coli</i> commensal pigs |
| url | https://www.mdpi.com/2079-6382/12/11/1616 |
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