Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes assembling complex natural products. Here, the structures of a Thermobifida fusca NRPS condensation domain bound to the substrate-bearing peptidyl carrier protein (PCP) domain provide insight into the mechanisms of substrate selecti...
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Bibliographic Details
| Main Authors: |
Thierry Izoré,
Y. T. Candace Ho,
Joe A. Kaczmarski,
Athina Gavriilidou,
Ka Ho Chow,
David L. Steer,
Robert J. A. Goode,
Ralf B. Schittenhelm,
Julien Tailhades,
Manuela Tosin,
Gregory L. Challis,
Elizabeth H. Krenske,
Nadine Ziemert,
Colin J. Jackson,
Max J. Cryle |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-22623-0
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