Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature
We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/8/496 |
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| author | Scott E. Boebinger Rowan O. Brothers Sistania Bong Bharat Sanders Courtney McCracken Lena H. Ting Erin M. Buckley |
| author_facet | Scott E. Boebinger Rowan O. Brothers Sistania Bong Bharat Sanders Courtney McCracken Lena H. Ting Erin M. Buckley |
| author_sort | Scott E. Boebinger |
| collection | DOAJ |
| description | We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions (VO<sub>2VO</sub> and VO<sub>2AO</sub>, respectively). However, this technique is not suitable for continuous monitoring, and its utility is limited to those who can tolerate occlusions. Combining NIRS with diffuse correlated spectroscopy (DCS) enables continuous measurement of an index of muscle oxygen metabolism (VO<sub>2i</sub>). Despite the lack of previous validation, VO<sub>2i</sub> is employed as a measure of oxygen metabolism in the muscle. Here we characterized measurement repeatability and compared VO<sub>2i</sub> with VO<sub>2VO</sub> and VO<sub>2AO</sub> in the medial gastrocnemius (MG) in 9 healthy adults. Intra-participant repeatability of VO<sub>2i</sub>, VO<sub>2VO</sub>, and VO<sub>2AO</sub> were excellent. VO<sub>2i</sub> was not significantly correlated with VO<sub>2AO</sub> (<i>p</i> = 0.15) nor VO<sub>2VO</sub> (<i>p</i> = 0.55). This lack of correlation suggests that the variability in the calibration coefficient between VO<sub>2i</sub> and VO<sub>2AO</sub>/VO<sub>2VO</sub> in the MG is substantial across participants. Thus, it is preferable to calibrate VO<sub>2i</sub> prior to every monitoring session. Important future work is needed to compare VO<sub>2i</sub> against gold standard modalities such as positron emission tomography or magnetic resonance imaging. |
| first_indexed | 2024-03-10T08:36:40Z |
| format | Article |
| id | doaj.art-fbb854f5cee745778f8fd0a2582f9905 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T08:36:40Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-fbb854f5cee745778f8fd0a2582f99052023-11-22T08:39:08ZengMDPI AGMetabolites2218-19892021-07-0111849610.3390/metabo11080496Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg MusculatureScott E. Boebinger0Rowan O. Brothers1Sistania Bong2Bharat Sanders3Courtney McCracken4Lena H. Ting5Erin M. Buckley6Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, USACenter for Research and Evaluation, Kaiser Permanente of Georgia, Atlanta, GA 30309, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, USAWe lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions (VO<sub>2VO</sub> and VO<sub>2AO</sub>, respectively). However, this technique is not suitable for continuous monitoring, and its utility is limited to those who can tolerate occlusions. Combining NIRS with diffuse correlated spectroscopy (DCS) enables continuous measurement of an index of muscle oxygen metabolism (VO<sub>2i</sub>). Despite the lack of previous validation, VO<sub>2i</sub> is employed as a measure of oxygen metabolism in the muscle. Here we characterized measurement repeatability and compared VO<sub>2i</sub> with VO<sub>2VO</sub> and VO<sub>2AO</sub> in the medial gastrocnemius (MG) in 9 healthy adults. Intra-participant repeatability of VO<sub>2i</sub>, VO<sub>2VO</sub>, and VO<sub>2AO</sub> were excellent. VO<sub>2i</sub> was not significantly correlated with VO<sub>2AO</sub> (<i>p</i> = 0.15) nor VO<sub>2VO</sub> (<i>p</i> = 0.55). This lack of correlation suggests that the variability in the calibration coefficient between VO<sub>2i</sub> and VO<sub>2AO</sub>/VO<sub>2VO</sub> in the MG is substantial across participants. Thus, it is preferable to calibrate VO<sub>2i</sub> prior to every monitoring session. Important future work is needed to compare VO<sub>2i</sub> against gold standard modalities such as positron emission tomography or magnetic resonance imaging.https://www.mdpi.com/2218-1989/11/8/496near-infrared spectroscopydiffuse correlation spectroscopymuscleoxygen metabolismblood flow |
| spellingShingle | Scott E. Boebinger Rowan O. Brothers Sistania Bong Bharat Sanders Courtney McCracken Lena H. Ting Erin M. Buckley Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature Metabolites near-infrared spectroscopy diffuse correlation spectroscopy muscle oxygen metabolism blood flow |
| title | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
| title_full | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
| title_fullStr | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
| title_full_unstemmed | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
| title_short | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
| title_sort | diffuse optical spectroscopy assessment of resting oxygen metabolism in the leg musculature |
| topic | near-infrared spectroscopy diffuse correlation spectroscopy muscle oxygen metabolism blood flow |
| url | https://www.mdpi.com/2218-1989/11/8/496 |
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