Risk for Tuberculosis among Children
Contacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-γ (IFN-γ) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-γ-based assay (Qua...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2006-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/12/9/05-1606_article |
| _version_ | 1818240097035747328 |
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| author | Hiroshi Nakaoka Lovett Lawson S. Bertel Squire Brian Coulter Pernille Ravn Inger Brock C. Anthony Hart Luis E. Cuevas |
| author_facet | Hiroshi Nakaoka Lovett Lawson S. Bertel Squire Brian Coulter Pernille Ravn Inger Brock C. Anthony Hart Luis E. Cuevas |
| author_sort | Hiroshi Nakaoka |
| collection | DOAJ |
| description | Contacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-γ (IFN-γ) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-γ-based assay (QuantiFERON Gold in Tube [QFT-IT] test) for 207 children in Nigeria in 1 of 3 groups: contact with adults with smear-positive TB, contact with adults with smear-negative TB, and controls. For these 3 groups, respectively, TST results were >10 mm for 38 (49%) of 78, 13 (16%) of 83, and 6 (13%) of 46 and QFT-IT positive for 53 (74%) of 72, 8 (10%) of 81, and 4 (10.3%) of 39 (p<0.01). Most test discrepancies were TST negative; QFT-IT positive if in contact with TB-positive persons; and TST positive, QFT-IT negative if in contact with TB-negative persons or controls. TST may underestimate risk for infection with TB in children. |
| first_indexed | 2024-12-12T13:08:01Z |
| format | Article |
| id | doaj.art-fbbd78b561914c898ac74ecb2fe6d832 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T13:08:01Z |
| publishDate | 2006-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-fbbd78b561914c898ac74ecb2fe6d8322022-12-22T00:23:36ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592006-09-011291383138810.3201/eid1209.051606Risk for Tuberculosis among ChildrenHiroshi NakaokaLovett LawsonS. Bertel SquireBrian CoulterPernille RavnInger BrockC. Anthony HartLuis E. CuevasContacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-γ (IFN-γ) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-γ-based assay (QuantiFERON Gold in Tube [QFT-IT] test) for 207 children in Nigeria in 1 of 3 groups: contact with adults with smear-positive TB, contact with adults with smear-negative TB, and controls. For these 3 groups, respectively, TST results were >10 mm for 38 (49%) of 78, 13 (16%) of 83, and 6 (13%) of 46 and QFT-IT positive for 53 (74%) of 72, 8 (10%) of 81, and 4 (10.3%) of 39 (p<0.01). Most test discrepancies were TST negative; QFT-IT positive if in contact with TB-positive persons; and TST positive, QFT-IT negative if in contact with TB-negative persons or controls. TST may underestimate risk for infection with TB in children.https://wwwnc.cdc.gov/eid/article/12/9/05-1606_articleTuberculosisinterferon-γchildrenNigerialatent infectionsQuantiferon |
| spellingShingle | Hiroshi Nakaoka Lovett Lawson S. Bertel Squire Brian Coulter Pernille Ravn Inger Brock C. Anthony Hart Luis E. Cuevas Risk for Tuberculosis among Children Emerging Infectious Diseases Tuberculosis interferon-γ children Nigeria latent infections Quantiferon |
| title | Risk for Tuberculosis among Children |
| title_full | Risk for Tuberculosis among Children |
| title_fullStr | Risk for Tuberculosis among Children |
| title_full_unstemmed | Risk for Tuberculosis among Children |
| title_short | Risk for Tuberculosis among Children |
| title_sort | risk for tuberculosis among children |
| topic | Tuberculosis interferon-γ children Nigeria latent infections Quantiferon |
| url | https://wwwnc.cdc.gov/eid/article/12/9/05-1606_article |
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