Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients
Objective: Heparin-induced thrombocytopenia (HIT) is a life threatening complication of heparin therapy, causing thrombosis. The aim of our study was to find out the frequencies of HIT antibody seroconversion and clinical HIT in Turkish medical patients on different forms of heparins. Materials and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2009-12-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-37132 |
| _version_ | 1828021656724963328 |
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| author | Mahmut Yüksel Ömer Yiğitbaşı Turan Kürüm Enver Duran Mustafa Edis Emre Tekgündüz Muzaffer Demir |
| author_facet | Mahmut Yüksel Ömer Yiğitbaşı Turan Kürüm Enver Duran Mustafa Edis Emre Tekgündüz Muzaffer Demir |
| author_sort | Mahmut Yüksel |
| collection | DOAJ |
| description | Objective: Heparin-induced thrombocytopenia (HIT) is a life threatening complication of heparin therapy, causing thrombosis. The aim of our study was to find out the frequencies of HIT antibody seroconversion and clinical HIT in Turkish medical patients on different forms of heparins. Materials and Methods: Our study included 61 patients who were on unfractionated heparin (UFH) (n: 37) and low molecular weight heparin (LMWH) (n: 24) therapies. The frequency of HIT antibody formation was determined by means of antigenic (ELISA), and functional assays (serotonin release assay-SRA). Results: The seroconversion rates in UFH and LMWH groups were found to be 18.9% and 4.1% (ELISA), and 8.1% and 4.1% (SRA), respectively. One patient (2.1%) on UFH therapy developed deep vein thrombosis. No thromboembolic event was observed in patients taking LMWH. Conclusion: Seroconversion rates by means of antigenic and functional assays and clinical HIT were more common in patients on UFH than patients on LMWH therapy. |
| first_indexed | 2024-04-10T11:56:31Z |
| format | Article |
| id | doaj.art-fbbda9f81e014bb88ad0953c6057f55f |
| institution | Directory Open Access Journal |
| issn | 1300-7777 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:56:31Z |
| publishDate | 2009-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-fbbda9f81e014bb88ad0953c6057f55f2023-02-15T16:16:47ZengGalenos Publishing HouseTurkish Journal of Hematology1300-77771308-52632009-12-012604171175Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patientsMahmut YükselÖmer YiğitbaşıTuran KürümEnver DuranMustafa EdisEmre TekgündüzMuzaffer DemirObjective: Heparin-induced thrombocytopenia (HIT) is a life threatening complication of heparin therapy, causing thrombosis. The aim of our study was to find out the frequencies of HIT antibody seroconversion and clinical HIT in Turkish medical patients on different forms of heparins. Materials and Methods: Our study included 61 patients who were on unfractionated heparin (UFH) (n: 37) and low molecular weight heparin (LMWH) (n: 24) therapies. The frequency of HIT antibody formation was determined by means of antigenic (ELISA), and functional assays (serotonin release assay-SRA). Results: The seroconversion rates in UFH and LMWH groups were found to be 18.9% and 4.1% (ELISA), and 8.1% and 4.1% (SRA), respectively. One patient (2.1%) on UFH therapy developed deep vein thrombosis. No thromboembolic event was observed in patients taking LMWH. Conclusion: Seroconversion rates by means of antigenic and functional assays and clinical HIT were more common in patients on UFH than patients on LMWH therapy.http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-37132Heparin-induced thrombocytopeniamedical patientsTurkish cohortunfractionated heparinlow molecular weight heparin. |
| spellingShingle | Mahmut Yüksel Ömer Yiğitbaşı Turan Kürüm Enver Duran Mustafa Edis Emre Tekgündüz Muzaffer Demir Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients Turkish Journal of Hematology Heparin-induced thrombocytopenia medical patients Turkish cohort unfractionated heparin low molecular weight heparin. |
| title | Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients |
| title_full | Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients |
| title_fullStr | Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients |
| title_full_unstemmed | Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients |
| title_short | Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced thrombocytopenia in medical patients |
| title_sort | incidence of anti heparin platelet factor 4 antibodies and heparin induced thrombocytopenia in medical patients |
| topic | Heparin-induced thrombocytopenia medical patients Turkish cohort unfractionated heparin low molecular weight heparin. |
| url | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-37132 |
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