Dose Rate Effect on Cell Survival in BNCT
The output constancy of the accelerator used for boron neutron capture therapy (BNCT) is essential to ensuring anti-tumor efficacy and safety. BNCT as currently practiced requires a wide variety of beam quality assessments to ensure that RBE dose errors are maintained within 5%. However, the necessi...
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MDPI AG
2023-08-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/9/441 |
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| author | Katsumi Hirose Mariko Sato Koji Ichise Masahiko Aoki |
| author_facet | Katsumi Hirose Mariko Sato Koji Ichise Masahiko Aoki |
| author_sort | Katsumi Hirose |
| collection | DOAJ |
| description | The output constancy of the accelerator used for boron neutron capture therapy (BNCT) is essential to ensuring anti-tumor efficacy and safety. BNCT as currently practiced requires a wide variety of beam quality assessments to ensure that RBE dose errors are maintained within 5%. However, the necessity of maintaining a constant beam dose rate has not been fully discussed. We therefore clarified the effect of different physical dose rates of the accelerator BNCT on biological effects. SAS and A172 cells exposed to <sup>10</sup>B-boronophenylalanine were irradiated using a neutron beam (normal operating current, 100 μA) at the Aomori Quantum Science Center. Thermal neutron flux was attenuated to 50.0 ± 0.96% under 50 μA irradiation compared to that under 100 μA irradiation. Cells were given physical doses of 1.67 and 3.36 Gy at 30 and 60 mC, respectively, and survival was significantly increased after 50 μA irradiation for both cell types (<i>p</i> = 0.0052 for SAS; <i>p</i> = 0.046 for A172, for 60 mC). Differences in accelerator BNCT beam dose rates have non-negligible effects on biological effects. Dose rate fluctuations and differences should not be easily permitted to obtain consistent biological effects. |
| first_indexed | 2024-03-10T22:55:50Z |
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| id | doaj.art-fbbf398b3be04a52ac3a7a07bb653ee2 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T22:55:50Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-fbbf398b3be04a52ac3a7a07bb653ee22023-11-19T10:04:37ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-08-014596986699410.3390/cimb45090441Dose Rate Effect on Cell Survival in BNCTKatsumi Hirose0Mariko Sato1Koji Ichise2Masahiko Aoki3Department of Radiation Oncology, Graduate School of Medicine, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, JapanDepartment of Radiation Oncology, Graduate School of Medicine, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, JapanDepartment of Radiation Oncology, Graduate School of Medicine, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, JapanDepartment of Radiation Oncology, Graduate School of Medicine, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, JapanThe output constancy of the accelerator used for boron neutron capture therapy (BNCT) is essential to ensuring anti-tumor efficacy and safety. BNCT as currently practiced requires a wide variety of beam quality assessments to ensure that RBE dose errors are maintained within 5%. However, the necessity of maintaining a constant beam dose rate has not been fully discussed. We therefore clarified the effect of different physical dose rates of the accelerator BNCT on biological effects. SAS and A172 cells exposed to <sup>10</sup>B-boronophenylalanine were irradiated using a neutron beam (normal operating current, 100 μA) at the Aomori Quantum Science Center. Thermal neutron flux was attenuated to 50.0 ± 0.96% under 50 μA irradiation compared to that under 100 μA irradiation. Cells were given physical doses of 1.67 and 3.36 Gy at 30 and 60 mC, respectively, and survival was significantly increased after 50 μA irradiation for both cell types (<i>p</i> = 0.0052 for SAS; <i>p</i> = 0.046 for A172, for 60 mC). Differences in accelerator BNCT beam dose rates have non-negligible effects on biological effects. Dose rate fluctuations and differences should not be easily permitted to obtain consistent biological effects.https://www.mdpi.com/1467-3045/45/9/441boron neutron capture therapy (BNCT)dose rateborofalan(<sup>10</sup>B) |
| spellingShingle | Katsumi Hirose Mariko Sato Koji Ichise Masahiko Aoki Dose Rate Effect on Cell Survival in BNCT Current Issues in Molecular Biology boron neutron capture therapy (BNCT) dose rate borofalan(<sup>10</sup>B) |
| title | Dose Rate Effect on Cell Survival in BNCT |
| title_full | Dose Rate Effect on Cell Survival in BNCT |
| title_fullStr | Dose Rate Effect on Cell Survival in BNCT |
| title_full_unstemmed | Dose Rate Effect on Cell Survival in BNCT |
| title_short | Dose Rate Effect on Cell Survival in BNCT |
| title_sort | dose rate effect on cell survival in bnct |
| topic | boron neutron capture therapy (BNCT) dose rate borofalan(<sup>10</sup>B) |
| url | https://www.mdpi.com/1467-3045/45/9/441 |
| work_keys_str_mv | AT katsumihirose doserateeffectoncellsurvivalinbnct AT marikosato doserateeffectoncellsurvivalinbnct AT kojiichise doserateeffectoncellsurvivalinbnct AT masahikoaoki doserateeffectoncellsurvivalinbnct |