Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study
Background and Purpose: Reduced white matter (WM) integrity has been implicated in chronic kidney disease (CKD), especially in end-stage renal disease (ESRD). However, whether the differences in WM abnormalities exist in ESRD and non-end-stage CKD (NES-CKD) remains unclear. Hence, this study aimed t...
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| Format: | Article |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2021.774236/full |
| _version_ | 1818574417033166848 |
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| author | Yuhan Jiang Qiuyi Gao Yangyingqiu Liu Bingbing Gao Yiwei Che Liangjie Lin Jian Jiang Peipei Chang Qingwei Song Weiwei Wang Nan Wang Yanwei Miao |
| author_facet | Yuhan Jiang Qiuyi Gao Yangyingqiu Liu Bingbing Gao Yiwei Che Liangjie Lin Jian Jiang Peipei Chang Qingwei Song Weiwei Wang Nan Wang Yanwei Miao |
| author_sort | Yuhan Jiang |
| collection | DOAJ |
| description | Background and Purpose: Reduced white matter (WM) integrity has been implicated in chronic kidney disease (CKD), especially in end-stage renal disease (ESRD). However, whether the differences in WM abnormalities exist in ESRD and non-end-stage CKD (NES-CKD) remains unclear. Hence, this study aimed to investigate the WM microstructural changes between the two stages using diffusion tensor imaging (DTI) and explore the related influencing factors.Methods: Diffusion tensor imaging’ images were prospectively acquired from 18 patients with ESRD, 22 patients with NES-CKD, and 19 healthy controls (HCs). Tract-based spatial statistics (TBSS) was performed to assess the voxel-wise differences in WM abnormalities among the three groups. The relationships between DTI parameters and biochemical data were also analyzed.Results: Compared with NES-CKDs, FA value was significantly decreased, and AD value increased in ESRDs mainly in brain regions of bilateral anterior thalamic radiation (ATR), the genu and body of corpus callosum (CC), bilateral anterior corona radiata, superior corona radiata, and superior longitudinal fasciculus. Besides, extensive and symmetrical deep WM damages were observed in patients with ESRD, accompanied by increased MD and RD values. Multiple regression analysis revealed that uric acid and serum phosphorus level can be used as independent predictors of WM microstructural abnormalities in clusters with statistical differences in DTI parameters between ESRD and NES-CKD groups.Conclusion: In the progression of CKD, patients with ESRD have more severe WM microstructural abnormalities than NES-CKDs, and this progressive deterioration may be related to uric acid and phosphate levels. |
| first_indexed | 2024-12-15T00:26:22Z |
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| id | doaj.art-fbc189a9b06647dcb0eb9e84698a8fb6 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-15T00:26:22Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-fbc189a9b06647dcb0eb9e84698a8fb62022-12-21T22:42:09ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-12-011510.3389/fnhum.2021.774236774236Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics StudyYuhan Jiang0Qiuyi Gao1Yangyingqiu Liu2Bingbing Gao3Yiwei Che4Liangjie Lin5Jian Jiang6Peipei Chang7Qingwei Song8Weiwei Wang9Nan Wang10Yanwei Miao11Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Third People’s Hospital of Dalian, Dalian, ChinaPhilips Healthcare China, Beijing, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaBackground and Purpose: Reduced white matter (WM) integrity has been implicated in chronic kidney disease (CKD), especially in end-stage renal disease (ESRD). However, whether the differences in WM abnormalities exist in ESRD and non-end-stage CKD (NES-CKD) remains unclear. Hence, this study aimed to investigate the WM microstructural changes between the two stages using diffusion tensor imaging (DTI) and explore the related influencing factors.Methods: Diffusion tensor imaging’ images were prospectively acquired from 18 patients with ESRD, 22 patients with NES-CKD, and 19 healthy controls (HCs). Tract-based spatial statistics (TBSS) was performed to assess the voxel-wise differences in WM abnormalities among the three groups. The relationships between DTI parameters and biochemical data were also analyzed.Results: Compared with NES-CKDs, FA value was significantly decreased, and AD value increased in ESRDs mainly in brain regions of bilateral anterior thalamic radiation (ATR), the genu and body of corpus callosum (CC), bilateral anterior corona radiata, superior corona radiata, and superior longitudinal fasciculus. Besides, extensive and symmetrical deep WM damages were observed in patients with ESRD, accompanied by increased MD and RD values. Multiple regression analysis revealed that uric acid and serum phosphorus level can be used as independent predictors of WM microstructural abnormalities in clusters with statistical differences in DTI parameters between ESRD and NES-CKD groups.Conclusion: In the progression of CKD, patients with ESRD have more severe WM microstructural abnormalities than NES-CKDs, and this progressive deterioration may be related to uric acid and phosphate levels.https://www.frontiersin.org/articles/10.3389/fnhum.2021.774236/fulltract-based spatial statisticschronic kidney diseaseend-stage renal diseaseuric acidphosphate |
| spellingShingle | Yuhan Jiang Qiuyi Gao Yangyingqiu Liu Bingbing Gao Yiwei Che Liangjie Lin Jian Jiang Peipei Chang Qingwei Song Weiwei Wang Nan Wang Yanwei Miao Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study Frontiers in Human Neuroscience tract-based spatial statistics chronic kidney disease end-stage renal disease uric acid phosphate |
| title | Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study |
| title_full | Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study |
| title_fullStr | Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study |
| title_full_unstemmed | Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study |
| title_short | Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study |
| title_sort | reduced white matter integrity in patients with end stage and non end stage chronic kidney disease a tract based spatial statistics study |
| topic | tract-based spatial statistics chronic kidney disease end-stage renal disease uric acid phosphate |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2021.774236/full |
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