Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue
Abstract Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) act in the proteolysis of basement membrane and extracellular matrix structures, facilitating tumor invasion. The purpose of this study was to evaluate the relationship between these proteins and clinicopathological paramete...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Pesquisa Odontológica
2018-09-01
|
| Series: | Brazilian Oral Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100266&lng=en&tlng=en |
| _version_ | 1818919577708396544 |
|---|---|
| author | Marianna Sampaio SERPA Rodrigo Porpino MAFRA Salomão Israel Monteiro Lourenço QUEIROZ Leorik Pereira da SILVA Lélia Batista de SOUZA Leão Pereira PINTO |
| author_facet | Marianna Sampaio SERPA Rodrigo Porpino MAFRA Salomão Israel Monteiro Lourenço QUEIROZ Leorik Pereira da SILVA Lélia Batista de SOUZA Leão Pereira PINTO |
| author_sort | Marianna Sampaio SERPA |
| collection | DOAJ |
| description | Abstract Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) act in the proteolysis of basement membrane and extracellular matrix structures, facilitating tumor invasion. The purpose of this study was to evaluate the relationship between these proteins and clinicopathological parameters in squamous cell carcinoma of the oral tongue (SCCOT). Sixty cases of SCCOT were submitted to immunohistochemistry and analyzed semiquantitatively at the invasion front and in the tumor core. The results were associated with lymph node metastasis, clinical stage, locoregional recurrence, clinical outcome and histological grade of malignancy. A higher expression of uPA was observed in cases of tumors of high-grade versus low-grade malignancy (p = 0.010). Moreover, the cases with the worst pattern of invasion presented an overexpression of uPA (p = 0.011). The presence of locoregional recurrence was associated with uPAR (p = 0.039), and the expression of both biomarkers was much higher at the invasion front than in the tumor core (p < 0.001). The results suggest uPA and uPAR are involved in the progression and aggressiveness of SCCOT, mainly at the tumor-host interface. |
| first_indexed | 2024-12-20T01:08:04Z |
| format | Article |
| id | doaj.art-fbc19996feaf417788ff187c625cf753 |
| institution | Directory Open Access Journal |
| issn | 1807-3107 |
| language | English |
| last_indexed | 2024-12-20T01:08:04Z |
| publishDate | 2018-09-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj.art-fbc19996feaf417788ff187c625cf7532022-12-21T19:58:46ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1807-31072018-09-0132010.1590/1807-3107bor-2018.vol32.0093S1806-83242018000100266Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongueMarianna Sampaio SERPARodrigo Porpino MAFRASalomão Israel Monteiro Lourenço QUEIROZLeorik Pereira da SILVALélia Batista de SOUZALeão Pereira PINTOAbstract Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) act in the proteolysis of basement membrane and extracellular matrix structures, facilitating tumor invasion. The purpose of this study was to evaluate the relationship between these proteins and clinicopathological parameters in squamous cell carcinoma of the oral tongue (SCCOT). Sixty cases of SCCOT were submitted to immunohistochemistry and analyzed semiquantitatively at the invasion front and in the tumor core. The results were associated with lymph node metastasis, clinical stage, locoregional recurrence, clinical outcome and histological grade of malignancy. A higher expression of uPA was observed in cases of tumors of high-grade versus low-grade malignancy (p = 0.010). Moreover, the cases with the worst pattern of invasion presented an overexpression of uPA (p = 0.011). The presence of locoregional recurrence was associated with uPAR (p = 0.039), and the expression of both biomarkers was much higher at the invasion front than in the tumor core (p < 0.001). The results suggest uPA and uPAR are involved in the progression and aggressiveness of SCCOT, mainly at the tumor-host interface.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100266&lng=en&tlng=enCarcinoma, Squamous CellImmunohistochemistryPlasminogen Activator |
| spellingShingle | Marianna Sampaio SERPA Rodrigo Porpino MAFRA Salomão Israel Monteiro Lourenço QUEIROZ Leorik Pereira da SILVA Lélia Batista de SOUZA Leão Pereira PINTO Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue Brazilian Oral Research Carcinoma, Squamous Cell Immunohistochemistry Plasminogen Activator |
| title | Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
| title_full | Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
| title_fullStr | Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
| title_full_unstemmed | Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
| title_short | Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
| title_sort | expression of urokinase type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue |
| topic | Carcinoma, Squamous Cell Immunohistochemistry Plasminogen Activator |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100266&lng=en&tlng=en |
| work_keys_str_mv | AT mariannasampaioserpa expressionofurokinasetypeplasminogenactivatoranditsreceptorinsquamouscellcarcinomaoftheoraltongue AT rodrigoporpinomafra expressionofurokinasetypeplasminogenactivatoranditsreceptorinsquamouscellcarcinomaoftheoraltongue AT salomaoisraelmonteirolourencoqueiroz expressionofurokinasetypeplasminogenactivatoranditsreceptorinsquamouscellcarcinomaoftheoraltongue AT leorikpereiradasilva expressionofurokinasetypeplasminogenactivatoranditsreceptorinsquamouscellcarcinomaoftheoraltongue AT leliabatistadesouza expressionofurokinasetypeplasminogenactivatoranditsreceptorinsquamouscellcarcinomaoftheoraltongue AT leaopereirapinto expressionofurokinasetypeplasminogenactivatoranditsreceptorinsquamouscellcarcinomaoftheoraltongue |