The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain.

The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain.

The COP9 signalosome (CSN) is a eukaryotic protein complex, which regulates a wide range of biological processes mainly through modulating the cullin ubiquitin E3 ligases in the ubiquitin-proteasome pathway. The CSN possesses a highly conserved deneddylase activity that centers at the JAMM motif of...

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Bibliographic Details
Main Authors: Elah Pick, Amnon Golan, Jacob Z Zimbler, Liquan Guo, Yehonatan Sharaby, Tomohiko Tsuge, Kay Hofmann, Ning Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3431379?pdf=render

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