Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis
Psoriasis is a chronic, immune-mediated and inflammatory skin disease. Although various biological drugs are available for psoriasis treatment, some patients have poor responses or do not respond to treatment. The aim of the present study was to highlight the molecular mechanism of responsiveness to...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/8/2024 |
| _version_ | 1797583524780310528 |
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| author | Martina Krušič Gregor Jezernik Uroš Potočnik |
| author_facet | Martina Krušič Gregor Jezernik Uroš Potočnik |
| author_sort | Martina Krušič |
| collection | DOAJ |
| description | Psoriasis is a chronic, immune-mediated and inflammatory skin disease. Although various biological drugs are available for psoriasis treatment, some patients have poor responses or do not respond to treatment. The aim of the present study was to highlight the molecular mechanism of responsiveness to current biological drugs for psoriasis treatment. To this end, we reviewed previously published articles that reported genes associated with treatment response to biological drugs in psoriasis, and gene ontology analysis was subsequently performed using the Cytoscape platform. Herein, we revealed a statistically significant association between NF-kappaB signaling (<i>p</i> value = 3.37 × 10<sup>−9</sup>), regulation of granulocyte macrophage colony-stimulating factor production (<i>p</i> value = 6.20 × 10<sup>−6</sup>), glial cell proliferation (<i>p</i> value = 2.41 × 10<sup>−5</sup>) and treatment response in psoriatic patients. To the best of our knowledge, we are the first to directly associate glial cells with treatment response. Taken together, our study revealed gene ontology (GO) terms, some of which were previously shown to be implicated in the molecular pathway of psoriasis, as novel GO terms involved in responsiveness in psoriatic disease patients. |
| first_indexed | 2024-03-10T23:40:07Z |
| format | Article |
| id | doaj.art-fbc28cb1b2584f52b3d1c2e4e4301580 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:40:07Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-fbc28cb1b2584f52b3d1c2e4e43015802023-11-19T02:35:32ZengMDPI AGPharmaceutics1999-49232023-07-01158202410.3390/pharmaceutics15082024Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in PsoriasisMartina Krušič0Gregor Jezernik1Uroš Potočnik2Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, SloveniaCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, SloveniaCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, SloveniaPsoriasis is a chronic, immune-mediated and inflammatory skin disease. Although various biological drugs are available for psoriasis treatment, some patients have poor responses or do not respond to treatment. The aim of the present study was to highlight the molecular mechanism of responsiveness to current biological drugs for psoriasis treatment. To this end, we reviewed previously published articles that reported genes associated with treatment response to biological drugs in psoriasis, and gene ontology analysis was subsequently performed using the Cytoscape platform. Herein, we revealed a statistically significant association between NF-kappaB signaling (<i>p</i> value = 3.37 × 10<sup>−9</sup>), regulation of granulocyte macrophage colony-stimulating factor production (<i>p</i> value = 6.20 × 10<sup>−6</sup>), glial cell proliferation (<i>p</i> value = 2.41 × 10<sup>−5</sup>) and treatment response in psoriatic patients. To the best of our knowledge, we are the first to directly associate glial cells with treatment response. Taken together, our study revealed gene ontology (GO) terms, some of which were previously shown to be implicated in the molecular pathway of psoriasis, as novel GO terms involved in responsiveness in psoriatic disease patients.https://www.mdpi.com/1999-4923/15/8/2024psoriasisbiological treatmenttherapy outcomegene ontology |
| spellingShingle | Martina Krušič Gregor Jezernik Uroš Potočnik Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis Pharmaceutics psoriasis biological treatment therapy outcome gene ontology |
| title | Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis |
| title_full | Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis |
| title_fullStr | Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis |
| title_full_unstemmed | Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis |
| title_short | Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis |
| title_sort | gene ontology analysis highlights biological processes influencing responsiveness to biological therapy in psoriasis |
| topic | psoriasis biological treatment therapy outcome gene ontology |
| url | https://www.mdpi.com/1999-4923/15/8/2024 |
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