Metabolic response to CNS infection with flaviviruses
Abstract Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, including neuroinfections, that can lead to serious metabolic consequences and even death. Some of the diseases caused by flaviviruses occur continuously in certain region...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-023-02898-4 |
| _version_ | 1797557665282392064 |
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| author | Marta Dobrzyńska Anna Moniuszko-Malinowska Elżbieta Skrzydlewska |
| author_facet | Marta Dobrzyńska Anna Moniuszko-Malinowska Elżbieta Skrzydlewska |
| author_sort | Marta Dobrzyńska |
| collection | DOAJ |
| description | Abstract Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, including neuroinfections, that can lead to serious metabolic consequences and even death. Some of the diseases caused by flaviviruses occur continuously in certain regions, while others occur intermittently or sporadically, causing epidemics. Some of the most common flaviviruses are West Nile virus, dengue virus, tick-borne encephalitis virus, Zika virus and Japanese encephalitis virus. Since all the above-mentioned viruses are capable of penetrating the blood–brain barrier through different mechanisms, their actions also affect the central nervous system (CNS). Like other viruses, flaviviruses, after entering the human body, contribute to redox imbalance and, consequently, to oxidative stress, which promotes inflammation in skin cells, in the blood and in CNS. This review focuses on discussing the effects of oxidative stress and inflammation resulting from pathogen invasion on the metabolic antiviral response of the host, and the ability of viruses to evade the consequences of metabolic changes or exploit them for increased replication and further progression of infection, which affects the development of sequelae and difficulties in therapy. |
| first_indexed | 2024-03-10T17:19:50Z |
| format | Article |
| id | doaj.art-fbc3dee261604b06a3c7e7212da4ba92 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-03-10T17:19:50Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-fbc3dee261604b06a3c7e7212da4ba922023-11-20T10:24:08ZengBMCJournal of Neuroinflammation1742-20942023-09-0120112210.1186/s12974-023-02898-4Metabolic response to CNS infection with flavivirusesMarta Dobrzyńska0Anna Moniuszko-Malinowska1Elżbieta Skrzydlewska2Department of Analytical Chemistry, Medical University of BiałystokDepartment of Infectious Diseases and Neuroinfections, Medical University of BialystokDepartment of Analytical Chemistry, Medical University of BiałystokAbstract Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, including neuroinfections, that can lead to serious metabolic consequences and even death. Some of the diseases caused by flaviviruses occur continuously in certain regions, while others occur intermittently or sporadically, causing epidemics. Some of the most common flaviviruses are West Nile virus, dengue virus, tick-borne encephalitis virus, Zika virus and Japanese encephalitis virus. Since all the above-mentioned viruses are capable of penetrating the blood–brain barrier through different mechanisms, their actions also affect the central nervous system (CNS). Like other viruses, flaviviruses, after entering the human body, contribute to redox imbalance and, consequently, to oxidative stress, which promotes inflammation in skin cells, in the blood and in CNS. This review focuses on discussing the effects of oxidative stress and inflammation resulting from pathogen invasion on the metabolic antiviral response of the host, and the ability of viruses to evade the consequences of metabolic changes or exploit them for increased replication and further progression of infection, which affects the development of sequelae and difficulties in therapy.https://doi.org/10.1186/s12974-023-02898-4FlavivirusesViral infectionsCNSNeuroinfectionsOxidative stressInflammation |
| spellingShingle | Marta Dobrzyńska Anna Moniuszko-Malinowska Elżbieta Skrzydlewska Metabolic response to CNS infection with flaviviruses Journal of Neuroinflammation Flaviviruses Viral infections CNS Neuroinfections Oxidative stress Inflammation |
| title | Metabolic response to CNS infection with flaviviruses |
| title_full | Metabolic response to CNS infection with flaviviruses |
| title_fullStr | Metabolic response to CNS infection with flaviviruses |
| title_full_unstemmed | Metabolic response to CNS infection with flaviviruses |
| title_short | Metabolic response to CNS infection with flaviviruses |
| title_sort | metabolic response to cns infection with flaviviruses |
| topic | Flaviviruses Viral infections CNS Neuroinfections Oxidative stress Inflammation |
| url | https://doi.org/10.1186/s12974-023-02898-4 |
| work_keys_str_mv | AT martadobrzynska metabolicresponsetocnsinfectionwithflaviviruses AT annamoniuszkomalinowska metabolicresponsetocnsinfectionwithflaviviruses AT elzbietaskrzydlewska metabolicresponsetocnsinfectionwithflaviviruses |