An innovative multi-modal retinal imaging system for in vivo retinal detection in small animals
This paper presents an innovative retinal imaging system tailored for in vivo fundus detection in small animals. This system integrates Scanning Laser Ophthalmoscopy (SLO) and optical Coherence Tomography (OCT) techniques, enabling the simultaneous generation of images from various modalities, inclu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Ophthalmology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fopht.2023.1251328/full |
| _version_ | 1797262549926805504 |
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| author | Zhengyuan Tang Tianze Zhao Ji Ren Kuan Zhang Qi Yin Teng Zhang Hui Zhang Tianyu Dong Pengfei Zhang Jie Zhang |
| author_facet | Zhengyuan Tang Tianze Zhao Ji Ren Kuan Zhang Qi Yin Teng Zhang Hui Zhang Tianyu Dong Pengfei Zhang Jie Zhang |
| author_sort | Zhengyuan Tang |
| collection | DOAJ |
| description | This paper presents an innovative retinal imaging system tailored for in vivo fundus detection in small animals. This system integrates Scanning Laser Ophthalmoscopy (SLO) and optical Coherence Tomography (OCT) techniques, enabling the simultaneous generation of images from various modalities, including SLO reflectance, SLO fluorescein angiogram, OCT, and OCT angiogram. The existing multi-modal retinal imaging systems generally encounter limitations such as the inability to detect peripheral lesion areas attributed to small Field of View (FOV) design and susceptibility to sample motion due to slow data acquisition speed. To address these challenges, it’s essential to underscore that this proposed system offers a range of notable advantages, including its compact design, the capacity for widefield imaging with a FOV of up to 100°, and a rapid OCT A-scan rate of 250 kHz, notably exceeding the capabilities of pre-existing multi-modal retinal imaging systems. Validation of the system involved imaging the eyes of normal wild-type mice and diseased mice afflicted with retinal detachment and choroidal neovascularization (CNV). The favorable imaging results demonstrate the system’s reliability in identifying retinal lesions in small animals. |
| first_indexed | 2024-04-24T23:58:53Z |
| format | Article |
| id | doaj.art-fbc5166f5b1a4d898a6ae1118796a709 |
| institution | Directory Open Access Journal |
| issn | 2674-0826 |
| language | English |
| last_indexed | 2024-04-24T23:58:53Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Ophthalmology |
| spelling | doaj.art-fbc5166f5b1a4d898a6ae1118796a7092024-03-14T10:51:14ZengFrontiers Media S.A.Frontiers in Ophthalmology2674-08262023-09-01310.3389/fopht.2023.12513281251328An innovative multi-modal retinal imaging system for in vivo retinal detection in small animalsZhengyuan Tang0Tianze Zhao1Ji Ren2Kuan Zhang3Qi Yin4Teng Zhang5Hui Zhang6Tianyu Dong7Pengfei Zhang8Jie Zhang9Advanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, Jiangsu, ChinaAdvanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, Jiangsu, ChinaAdvanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, Jiangsu, ChinaAdvanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, Jiangsu, ChinaAdvanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, Jiangsu, ChinaAdvanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, Jiangsu, ChinaOphthalmology Department, Tri-Apex Laboratories Co., LTD, Nanjing, Jiangsu, ChinaOphthalmology Department, Tri-Apex Laboratories Co., LTD, Nanjing, Jiangsu, ChinaSchool of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian, ChinaAdvanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, Jiangsu, ChinaThis paper presents an innovative retinal imaging system tailored for in vivo fundus detection in small animals. This system integrates Scanning Laser Ophthalmoscopy (SLO) and optical Coherence Tomography (OCT) techniques, enabling the simultaneous generation of images from various modalities, including SLO reflectance, SLO fluorescein angiogram, OCT, and OCT angiogram. The existing multi-modal retinal imaging systems generally encounter limitations such as the inability to detect peripheral lesion areas attributed to small Field of View (FOV) design and susceptibility to sample motion due to slow data acquisition speed. To address these challenges, it’s essential to underscore that this proposed system offers a range of notable advantages, including its compact design, the capacity for widefield imaging with a FOV of up to 100°, and a rapid OCT A-scan rate of 250 kHz, notably exceeding the capabilities of pre-existing multi-modal retinal imaging systems. Validation of the system involved imaging the eyes of normal wild-type mice and diseased mice afflicted with retinal detachment and choroidal neovascularization (CNV). The favorable imaging results demonstrate the system’s reliability in identifying retinal lesions in small animals.https://www.frontiersin.org/articles/10.3389/fopht.2023.1251328/fullreflectance retinal imagingfluorescein angiographyoptical coherence tomographyoptical coherence tomography angiographyconfocal scanning laser ophthalmoscopysmall animal retinal imaging |
| spellingShingle | Zhengyuan Tang Tianze Zhao Ji Ren Kuan Zhang Qi Yin Teng Zhang Hui Zhang Tianyu Dong Pengfei Zhang Jie Zhang An innovative multi-modal retinal imaging system for in vivo retinal detection in small animals Frontiers in Ophthalmology reflectance retinal imaging fluorescein angiography optical coherence tomography optical coherence tomography angiography confocal scanning laser ophthalmoscopy small animal retinal imaging |
| title | An innovative multi-modal retinal imaging system for in vivo retinal detection in small animals |
| title_full | An innovative multi-modal retinal imaging system for in vivo retinal detection in small animals |
| title_fullStr | An innovative multi-modal retinal imaging system for in vivo retinal detection in small animals |
| title_full_unstemmed | An innovative multi-modal retinal imaging system for in vivo retinal detection in small animals |
| title_short | An innovative multi-modal retinal imaging system for in vivo retinal detection in small animals |
| title_sort | innovative multi modal retinal imaging system for in vivo retinal detection in small animals |
| topic | reflectance retinal imaging fluorescein angiography optical coherence tomography optical coherence tomography angiography confocal scanning laser ophthalmoscopy small animal retinal imaging |
| url | https://www.frontiersin.org/articles/10.3389/fopht.2023.1251328/full |
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