Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model
This study designed, characterized, and investigated the antioxidant and anti-inflammatory effects of gold nanoparticles coated with Viburnum opulus extract (AuNP-VO) compared to those of Viburnum opulus fruit extract (VO) and indomethacin, on experimental inflammation in Wistar rats. The structure...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-04-01
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| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/17518253.2022.2061872 |
| _version_ | 1828803359916687360 |
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| author | Cristina Bidian Gabriela Adriana Filip Luminița David Bianca Moldovan Ioana Baldea Diana Olteanu Mara Filip Pompei Bolfa Monica Potara Alina Mihaela Toader Simona Clichici |
| author_facet | Cristina Bidian Gabriela Adriana Filip Luminița David Bianca Moldovan Ioana Baldea Diana Olteanu Mara Filip Pompei Bolfa Monica Potara Alina Mihaela Toader Simona Clichici |
| author_sort | Cristina Bidian |
| collection | DOAJ |
| description | This study designed, characterized, and investigated the antioxidant and anti-inflammatory effects of gold nanoparticles coated with Viburnum opulus extract (AuNP-VO) compared to those of Viburnum opulus fruit extract (VO) and indomethacin, on experimental inflammation in Wistar rats. The structure and properties of the synthesized AuNPs-VO were evaluated by UV-Vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential measurements. Their biological effects on paw inflammation were assessed at 2, 24, and 48 h after the administration of plantar carageenan by quantifying oxidative stress and inflammation and by histopathological analysis. TEM micrographs confirmed the spherical shape, homogeneous distribution, and nano-size of 65 nm. AuNP-VO and VO showed antioxidant and anti-inflammatory effects on plantar inflammation with different dynamics of action. AuNP-VO exerted antioxidant effects, especially, at 48 h and diminished the plantar inflammation in the early stages (IL-1α, IL-1β, IL-6, TNF-α and IL-10) and late stages (IL-1β, p < 0.01) whereas VO reduced the inflammatory response, predominantly in the early stages (p < 0.01; p < 0.001), and maintained reduced IL-1β values (p < 0.001) and a lower histopathological inflammatory score at 48 h. In conclusion, AuNP-VO and VO extract can be used as valuable agents for the treatment of diseases associated with inflammation. |
| first_indexed | 2024-12-12T07:21:49Z |
| format | Article |
| id | doaj.art-fbc57cf369ee4c3ab873807ca70204c8 |
| institution | Directory Open Access Journal |
| issn | 1751-8253 1751-7192 |
| language | English |
| last_indexed | 2024-12-12T07:21:49Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj.art-fbc57cf369ee4c3ab873807ca70204c82022-12-22T00:33:20ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922022-04-0115232033610.1080/17518253.2022.2061872Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema modelCristina Bidian0Gabriela Adriana Filip1Luminița David2Bianca Moldovan3Ioana Baldea4Diana Olteanu5Mara Filip6Pompei Bolfa7Monica Potara8Alina Mihaela Toader9Simona Clichici10Department of Physiology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Physiology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Chemistry, Faculty of Chemistry and Chemical Engineering, ‘Babes-Bolyai’ University, Cluj-Napoca, RomaniaDepartment of Chemistry, Faculty of Chemistry and Chemical Engineering, ‘Babes-Bolyai’ University, Cluj-Napoca, RomaniaDepartment of Physiology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Physiology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Physiology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Pathology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, RomaniaNanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, RomaniaDepartment of Physiology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Physiology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaThis study designed, characterized, and investigated the antioxidant and anti-inflammatory effects of gold nanoparticles coated with Viburnum opulus extract (AuNP-VO) compared to those of Viburnum opulus fruit extract (VO) and indomethacin, on experimental inflammation in Wistar rats. The structure and properties of the synthesized AuNPs-VO were evaluated by UV-Vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential measurements. Their biological effects on paw inflammation were assessed at 2, 24, and 48 h after the administration of plantar carageenan by quantifying oxidative stress and inflammation and by histopathological analysis. TEM micrographs confirmed the spherical shape, homogeneous distribution, and nano-size of 65 nm. AuNP-VO and VO showed antioxidant and anti-inflammatory effects on plantar inflammation with different dynamics of action. AuNP-VO exerted antioxidant effects, especially, at 48 h and diminished the plantar inflammation in the early stages (IL-1α, IL-1β, IL-6, TNF-α and IL-10) and late stages (IL-1β, p < 0.01) whereas VO reduced the inflammatory response, predominantly in the early stages (p < 0.01; p < 0.001), and maintained reduced IL-1β values (p < 0.001) and a lower histopathological inflammatory score at 48 h. In conclusion, AuNP-VO and VO extract can be used as valuable agents for the treatment of diseases associated with inflammation.https://www.tandfonline.com/doi/10.1080/17518253.2022.2061872Gold nanoparticlesViburnum opulusoxidative stressinflammation |
| spellingShingle | Cristina Bidian Gabriela Adriana Filip Luminița David Bianca Moldovan Ioana Baldea Diana Olteanu Mara Filip Pompei Bolfa Monica Potara Alina Mihaela Toader Simona Clichici Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model Green Chemistry Letters and Reviews Gold nanoparticles Viburnum opulus oxidative stress inflammation |
| title | Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model |
| title_full | Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model |
| title_fullStr | Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model |
| title_full_unstemmed | Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model |
| title_short | Viburnum opulus fruit extract-capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan-induced paw edema model |
| title_sort | viburnum opulus fruit extract capped gold nanoparticles attenuated oxidative stress and acute inflammation in carrageenan induced paw edema model |
| topic | Gold nanoparticles Viburnum opulus oxidative stress inflammation |
| url | https://www.tandfonline.com/doi/10.1080/17518253.2022.2061872 |
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