Unraveling Metabolic Changes following Stroke: Insights from a Urinary Metabolomics Analysis

Unraveling Metabolic Changes following Stroke: Insights from a Urinary Metabolomics Analysis

The neuropathological sequelae of stroke and subsequent recovery are incompletely understood. Here, we investigated the metabolic dynamics following stroke to advance the understanding of the pathophysiological mechanisms orchestrating stroke recovery. Using a nuclear magnetic resonance (NMR)-driven...

Full description

Bibliographic Details
Main Authors:	Jamie N. Petersson, Elani A. Bykowski, Chelsea Ekstrand, Sean P. Dukelow, Chester Ho, Chantel T. Debert, Tony Montina, Gerlinde A. S. Metz
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Series:	Metabolites
Subjects:	metabolomics urine stroke nuclear magnetic resonance (NMR) spectroscopy neurorehabilitation functional recovery
Online Access:	https://www.mdpi.com/2218-1989/14/3/145

Similar Items

Urinary biomarkers indicative of recovery from spinal cord injury: A pilot study
by: Elani A. Bykowski, et al.
Published: (2021-06-01)

Identification of Serum Metabolites as Prognostic Biomarkers Following Spinal Cord Injury: A Pilot Study
by: Elani A. Bykowski, et al.
Published: (2023-04-01)

Urinary metabolomic signatures as indicators of injury severity following traumatic brain injury: A pilot study
by: Elani A. Bykowski, et al.
Published: (2021-12-01)

Blood-Derived Metabolic Signatures as Biomarkers of Injury Severity in Traumatic Brain Injury: A Pilot Study
by: Elani A. Bykowski, et al.
Published: (2024-02-01)

Alterations in Urine Metabolomics Following Sport-Related Concussion: A 1H NMR-Based Analysis
by: Zachary R. Wanner, et al.
Published: (2021-08-01)

Urinary Metabolomics Study of Patients with Bicuspid Aortic Valve Disease
by: Massimo Chessa, et al.
Published: (2021-07-01)

First Insights into the Urinary Metabolome of Captive Giraffes by Proton Nuclear Magnetic Resonance Spectroscopy
by: Chenglin Zhu, et al.
Published: (2020-04-01)

Impact of Maternal Obesity on the Gestational Metabolome and Infant Metabolome, Brain, and Behavioral Development in Rhesus Macaques
by: Yu Hasegawa, et al.
Published: (2022-08-01)

A molecular signature for the metabolic syndrome by urine metabolomics
by: Chiara Bruzzone, et al.
Published: (2021-07-01)

1H-NMR-based urine metabolomics of prostate cancer and benign prostatic hyperplasia
by: Mohammed Zniber, et al.
Published: (2024-04-01)

Cluster Analysis Statistical Spectroscopy for the Identification of Metabolites in <sup>1</sup>H NMR Metabolomics
by: Silke S. Heinzmann, et al.
Published: (2022-10-01)

Changes in the Urine Metabolomic Profile in Patients Recovering from Severe COVID-19
by: Robert Rosolanka, et al.
Published: (2023-02-01)

Acute effects of moderate vs. vigorous endurance exercise on urinary metabolites in healthy, young, physically active men—A multi-platform metabolomics approach
by: Sina Kistner, et al.
Published: (2023-01-01)

NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes
by: Styliani A. Chasapi, et al.
Published: (2022-05-01)

Urinary Microbial and Metabolomic Profiles in Kidney Stone Disease
by: Hong Gao, et al.
Published: (2022-09-01)

Systems View of Deconditioning During Spaceflight Simulation in the PlanHab Project: The Departure of Urine 1 H-NMR Metabolomes From Healthy State in Young Males Subjected to Bedrest Inactivity and Hypoxia
by: Robert Šket, et al.
Published: (2020-12-01)

Fecal <sup>1</sup>H-NMR Metabolomics: A Comparison of Sample Preparation Methods for NMR and Novel in Silico Baseline Correction
by: Catherine L. J. Brown, et al.
Published: (2022-02-01)

Untargeted Urinary <sup>1</sup>H NMR-Based Metabolomic Pattern as a Potential Platform in Breast Cancer Detection
by: Catarina L. Silva, et al.
Published: (2019-11-01)

Urine NMR Metabolomics for Precision Oncology in Colorectal Cancer
by: Jesús Brezmes, et al.
Published: (2022-09-01)

A Unique Urinary Metabolic Feature for the Determination of Bladder Cancer, Prostate Cancer, and Renal Cell Carcinoma
by: Sujin Lee, et al.
Published: (2021-09-01)

Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats
by: Guangmang Liu, et al.
Published: (2016-08-01)

Exploratory urinary metabolomics of type 1 leprosy reactions
by: Oleg. A. Mayboroda, et al.
Published: (2016-04-01)

Urine Metabolomic Profile of Breast- versus Formula-Fed Neonates Using a Synbiotic-Enriched Formula
by: Vasiliki Falaina, et al.
Published: (2022-09-01)

Trans- and Multigenerational Maternal Social Isolation Stress Programs the Blood Plasma Metabolome in the F3 Generation
by: Joshua P. Heynen, et al.
Published: (2022-06-01)

Renal Cell Carcinoma: A Study through NMR-Based Metabolomics Combined with Transcriptomics
by: Rosa Ragone, et al.
Published: (2016-01-01)

Characterization of Yak Common Biofluids Metabolome by Means of Proton Nuclear Magnetic Resonance Spectroscopy
by: Chenglin Zhu, et al.
Published: (2019-03-01)

Relationship between Urinary Metabolomic Profiles and Depressive Episode in Antarctica
by: Kazuhiko Kasuya, et al.
Published: (2023-01-01)

A Study of the Effects of Exercise on the Urinary Metabolome Using Normalisation to Individual Metabolic Output
by: Evangelia Daskalaki, et al.
Published: (2015-02-01)

A metabolomic analytical approach permits identification of urinary biomarkers for Plasmodium falciparum infection: a case–control study
by: Salah Abdelrazig, et al.
Published: (2017-05-01)

Special Issue on “NMR-Based Metabolomics and Its Applications Volume 2”
by: Flaminia Cesare Marincola, et al.
Published: (2020-01-01)

A population-based urinary and plasma metabolomics study of environmental exposure to cadmium
by: Yoshiki Ishibashi, et al.
Published: (2024-03-01)

Urinary metabolomics reveals the biological characteristics of early pregnancy in pigs
by: Chen Zhou, et al.
Published: (2022-03-01)

Urinary Metabolomic Profiling in Streptozotocin-Induced Diabetic Mice after Treatment with Losartan
by: Jin Seong Hyeon, et al.
Published: (2020-11-01)

Perinatal Asphyxia: A Review from a Metabolomics Perspective
by: Claudia Fattuoni, et al.
Published: (2015-04-01)

Oral administration of Costa Rican guava (Psidium friedrichsthalianum) juice induces changes in urinary excretion of energy-related compounds in Wistar rats determined by 1H NMR
by: Alexander Montoya-Arroyo, et al.
Published: (2020-08-01)

Urinary Metabolomic Differentiation of Infants Fed on Human Breastmilk and Formulated Milk
by: Ji-Woo Yu, et al.
Published: (2024-02-01)

A Multi-Platform Metabolomics Approach Identifies Urinary Metabolite Signatures That Differentiate Ketotic From Healthy Dairy Cows
by: Guanshi Zhang, et al.
Published: (2021-01-01)

Development and Validation of a High-Throughput Mass Spectrometry Based Urine Metabolomic Test for the Detection of Colonic Adenomatous Polyps
by: Lu Deng, et al.
Published: (2017-06-01)

Influence of Freezing and Storage Procedure on Human Urine Samples in NMR-Based Metabolomics
by: Burkhard Luy, et al.
Published: (2013-04-01)

Metabolomic Profile of Young Adults Born Preterm
by: Serafina Perrone, et al.
Published: (2021-10-01)