Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report
Abstract Background Sacrococcygeal teratomas (SCTs) are the most common congenital neoplasm and often require resection soon after birth. There are rare reports of cardiac arrest during surgery due to manipulation of the tumor triggering secondary necrosis and hyperkalemia. Case presentation This ca...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-023-04193-w |
| _version_ | 1827633165217300480 |
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| author | Aditi Dey Rita Wyrebek Loraine Torres Danilo Escoto Fauzia Shakeel Jennifer Mayer |
| author_facet | Aditi Dey Rita Wyrebek Loraine Torres Danilo Escoto Fauzia Shakeel Jennifer Mayer |
| author_sort | Aditi Dey |
| collection | DOAJ |
| description | Abstract Background Sacrococcygeal teratomas (SCTs) are the most common congenital neoplasm and often require resection soon after birth. There are rare reports of cardiac arrest during surgery due to manipulation of the tumor triggering secondary necrosis and hyperkalemia. Case presentation This case describes a very preterm infant with a SCT who develops spontaneous preoperative tumor lysis syndrome (TLS). The medical team utilized rasburicase and the patient underwent total gross resection at 40 h of life. Conclusions We emphasize the importance of the early recognition and management of tumor lysis syndrome in SCT with rasburicase, aggressive management of hyperkalemia and consideration of early resection of SCTs even in the case of a very premature infant. |
| first_indexed | 2024-03-09T14:54:45Z |
| format | Article |
| id | doaj.art-fbc81bd4efcf44a5abcaca947892ddbe |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-09T14:54:45Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-fbc81bd4efcf44a5abcaca947892ddbe2023-11-26T14:15:52ZengBMCBMC Pediatrics1471-24312023-09-012311610.1186/s12887-023-04193-wTumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case reportAditi Dey0Rita Wyrebek1Loraine Torres2Danilo Escoto3Fauzia Shakeel4Jennifer Mayer5Maternal Fetal Neonatal Institute, Johns Hopkins All Children’s HospitalMaternal Fetal Neonatal Institute, Johns Hopkins All Children’s HospitalDepartment of Obstetrics and Gynecology, Bayfront Medical Center, Orlando HealthMaternal Fetal Neonatal Institute, Johns Hopkins All Children’s HospitalMaternal Fetal Neonatal Institute, Johns Hopkins All Children’s HospitalCancer and Blood Disorders Institute, Johns Hopkins All Children’s HospitalAbstract Background Sacrococcygeal teratomas (SCTs) are the most common congenital neoplasm and often require resection soon after birth. There are rare reports of cardiac arrest during surgery due to manipulation of the tumor triggering secondary necrosis and hyperkalemia. Case presentation This case describes a very preterm infant with a SCT who develops spontaneous preoperative tumor lysis syndrome (TLS). The medical team utilized rasburicase and the patient underwent total gross resection at 40 h of life. Conclusions We emphasize the importance of the early recognition and management of tumor lysis syndrome in SCT with rasburicase, aggressive management of hyperkalemia and consideration of early resection of SCTs even in the case of a very premature infant.https://doi.org/10.1186/s12887-023-04193-wGlucocorticoidsPremature infantPremature neonatesRasburicaseHyperkalemiaTumor lysis syndrome |
| spellingShingle | Aditi Dey Rita Wyrebek Loraine Torres Danilo Escoto Fauzia Shakeel Jennifer Mayer Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report BMC Pediatrics Glucocorticoids Premature infant Premature neonates Rasburicase Hyperkalemia Tumor lysis syndrome |
| title | Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report |
| title_full | Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report |
| title_fullStr | Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report |
| title_full_unstemmed | Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report |
| title_short | Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report |
| title_sort | tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma a case report |
| topic | Glucocorticoids Premature infant Premature neonates Rasburicase Hyperkalemia Tumor lysis syndrome |
| url | https://doi.org/10.1186/s12887-023-04193-w |
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