| Summary: | AbstractBackground/Aims:Studies
recently have demonstrated the association between the major cardiovascular
poor outcomes and uricacid (UA), the neutrophil/lymphocyteratio (NLR), lymphocyte counts. Barely, the relation
between uricacid-to-lymphocyteratio (UALR) levels and inflammatory markers in
ST elevated myocardial infarction (STEMI) hasn’t been investigated yet. In our
current study, we tried to investigate whether alterations UALR levels between
patients unstable angina pectoris (UAP) patients and STEMI patients who
underwent primary percutaneous coronary
intervention (PCI). In this context, were searched that altherelations
of UALR with myocardial injury markers (troponin I, creatine kinase-MB),
inflammatory markers (C-reactive protein, and covariaties of blood count),
patients' lipid profiles and myocardial contractility.Methods:A total
of 346 STEMI and UAP patients were enrolled in this retrospectively study.
T-test or Mann Witney U test was used to see the significant differences. We
found independent predictive factors for UA, NLR, and UALR for STEMI and ROC
analyses was performed for these parameters. Results:We showed significant
differences between UA, NLR and UALR levels (P lt;0.005)between STEMI and UAP
patients. We determined the optimal cut-off points as: 6.05mg/dL for UA (UAC
0.561, specifity%50, sensitivity%72); 0.179 for UALR (UAC 0.913,
specifity%96,sensitivity %92) ;2.3 for NLR (UAC 0.395, specifity %82, sensitivity %88). Conclusions: For
the first time in the literature, it has been demonstrated that UALR is a
distinct parameter associated with troponin I levels and myocardial
contractility, and is more sensitive and specific than the NLR, UA and CRP
parameters routinely used in STEMI.
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