Validation of kinetic modeling of progesterone release from polymeric membranes
Mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone (...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
|
| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087617301848 |
| _version_ | 1828193121874214912 |
|---|---|
| author | Analia Irma Romero Mercedes Villegas Alicia Graciela Cid Mónica Liliana Parentis Elio Emilio Gonzo José María Bermúdez |
| author_facet | Analia Irma Romero Mercedes Villegas Alicia Graciela Cid Mónica Liliana Parentis Elio Emilio Gonzo José María Bermúdez |
| author_sort | Analia Irma Romero |
| collection | DOAJ |
| description | Mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone (Prg) controlled release from poly-3-hydroxybutyric acid (PHB) membranes. A statistical analysis was conducted to compare the fitting of our model with six different models and the Akaike information criterion (AIC) was used to find the equation with best-fit. A simple relation between mass and drug released rate was found, which allows predicting the effect of Prg loads on the release behavior. Our proposed model was the one with minimum AIC value, and therefore it was the one that statistically fitted better the experimental data obtained for all the Prg loads tested. Furthermore, the initial release rate was calculated and therefore, the interface mass transfer coefficient estimated and the equilibrium distribution constant of Prg between the PHB and the release medium was also determined. The results lead us to conclude that our proposed model is the one which best fits the experimental data and can be successfully used to describe Prg drug release in PHB membranes. |
| first_indexed | 2024-04-12T09:03:13Z |
| format | Article |
| id | doaj.art-fbcb6f1f67f24ab9b0b7bf226569e2d3 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-04-12T09:03:13Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-fbcb6f1f67f24ab9b0b7bf226569e2d32022-12-22T03:39:10ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762018-01-01131546210.1016/j.ajps.2017.08.007Validation of kinetic modeling of progesterone release from polymeric membranesAnalia Irma Romero0Mercedes Villegas1Alicia Graciela Cid2Mónica Liliana Parentis3Elio Emilio Gonzo4José María Bermúdez5Instituto de Investigaciones para la Industria Química, Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta Capital 4400, ArgentinaInstituto de Investigaciones para la Industria Química, Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta Capital 4400, ArgentinaInstituto de Investigaciones para la Industria Química, Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta Capital 4400, ArgentinaInstituto de Investigaciones para la Industria Química, Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta Capital 4400, ArgentinaInstituto de Investigaciones para la Industria Química, Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta Capital 4400, ArgentinaInstituto de Investigaciones para la Industria Química, Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta Capital 4400, ArgentinaMathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone (Prg) controlled release from poly-3-hydroxybutyric acid (PHB) membranes. A statistical analysis was conducted to compare the fitting of our model with six different models and the Akaike information criterion (AIC) was used to find the equation with best-fit. A simple relation between mass and drug released rate was found, which allows predicting the effect of Prg loads on the release behavior. Our proposed model was the one with minimum AIC value, and therefore it was the one that statistically fitted better the experimental data obtained for all the Prg loads tested. Furthermore, the initial release rate was calculated and therefore, the interface mass transfer coefficient estimated and the equilibrium distribution constant of Prg between the PHB and the release medium was also determined. The results lead us to conclude that our proposed model is the one which best fits the experimental data and can be successfully used to describe Prg drug release in PHB membranes.http://www.sciencedirect.com/science/article/pii/S1818087617301848Mathematical modelsModel validationDrug delivery/releaseMass transfer coefficientEquilibrium distribution constant |
| spellingShingle | Analia Irma Romero Mercedes Villegas Alicia Graciela Cid Mónica Liliana Parentis Elio Emilio Gonzo José María Bermúdez Validation of kinetic modeling of progesterone release from polymeric membranes Asian Journal of Pharmaceutical Sciences Mathematical models Model validation Drug delivery/release Mass transfer coefficient Equilibrium distribution constant |
| title | Validation of kinetic modeling of progesterone release from polymeric membranes |
| title_full | Validation of kinetic modeling of progesterone release from polymeric membranes |
| title_fullStr | Validation of kinetic modeling of progesterone release from polymeric membranes |
| title_full_unstemmed | Validation of kinetic modeling of progesterone release from polymeric membranes |
| title_short | Validation of kinetic modeling of progesterone release from polymeric membranes |
| title_sort | validation of kinetic modeling of progesterone release from polymeric membranes |
| topic | Mathematical models Model validation Drug delivery/release Mass transfer coefficient Equilibrium distribution constant |
| url | http://www.sciencedirect.com/science/article/pii/S1818087617301848 |
| work_keys_str_mv | AT analiairmaromero validationofkineticmodelingofprogesteronereleasefrompolymericmembranes AT mercedesvillegas validationofkineticmodelingofprogesteronereleasefrompolymericmembranes AT aliciagracielacid validationofkineticmodelingofprogesteronereleasefrompolymericmembranes AT monicalilianaparentis validationofkineticmodelingofprogesteronereleasefrompolymericmembranes AT elioemiliogonzo validationofkineticmodelingofprogesteronereleasefrompolymericmembranes AT josemariabermudez validationofkineticmodelingofprogesteronereleasefrompolymericmembranes |