The Selectivity and Specificity of Autophagy in Drosophila
Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a significant role in cellular homeostasis. Despite the i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-06-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/1/3/248 |
| _version_ | 1797715887165276160 |
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| author | Ioannis P. Nezis |
| author_facet | Ioannis P. Nezis |
| author_sort | Ioannis P. Nezis |
| collection | DOAJ |
| description | Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a significant role in cellular homeostasis. Despite the initial belief that autophagy is a nonselective bulk process, there is growing evidence during the last years that sequestration and degradation of cellular material by autophagy can be accomplished in a selective and specific manner. Given the role of autophagy and selective autophagy in several disease related processes such as tumorigenesis, neurodegeneration and infections, it is very important to dissect the molecular mechanisms of selective autophagy, in the context of the system and the organism. An excellent genetically tractable model organism to study autophagy is Drosophila, which appears to have a highly conserved autophagic machinery compared with mammals. However, the mechanisms of selective autophagy in Drosophila have been largely unexplored. The aim of this review is to summarize recent discoveries about the selectivity of autophagy in Drosophila. |
| first_indexed | 2024-03-12T08:14:27Z |
| format | Article |
| id | doaj.art-fbcd6b9525f845e0880b0e73d8c3e1e6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:14:27Z |
| publishDate | 2012-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fbcd6b9525f845e0880b0e73d8c3e1e62023-09-02T19:02:37ZengMDPI AGCells2073-44092012-06-011324826210.3390/cells1030248The Selectivity and Specificity of Autophagy in DrosophilaIoannis P. NezisAutophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a significant role in cellular homeostasis. Despite the initial belief that autophagy is a nonselective bulk process, there is growing evidence during the last years that sequestration and degradation of cellular material by autophagy can be accomplished in a selective and specific manner. Given the role of autophagy and selective autophagy in several disease related processes such as tumorigenesis, neurodegeneration and infections, it is very important to dissect the molecular mechanisms of selective autophagy, in the context of the system and the organism. An excellent genetically tractable model organism to study autophagy is Drosophila, which appears to have a highly conserved autophagic machinery compared with mammals. However, the mechanisms of selective autophagy in Drosophila have been largely unexplored. The aim of this review is to summarize recent discoveries about the selectivity of autophagy in Drosophila.http://www.mdpi.com/2073-4409/1/3/248autophagydevelopmentDrosophilap62Ref(2)Pprogrammed cell deathselective autophagy receptors |
| spellingShingle | Ioannis P. Nezis The Selectivity and Specificity of Autophagy in Drosophila Cells autophagy development Drosophila p62 Ref(2)P programmed cell death selective autophagy receptors |
| title | The Selectivity and Specificity of Autophagy in Drosophila |
| title_full | The Selectivity and Specificity of Autophagy in Drosophila |
| title_fullStr | The Selectivity and Specificity of Autophagy in Drosophila |
| title_full_unstemmed | The Selectivity and Specificity of Autophagy in Drosophila |
| title_short | The Selectivity and Specificity of Autophagy in Drosophila |
| title_sort | selectivity and specificity of autophagy in drosophila |
| topic | autophagy development Drosophila p62 Ref(2)P programmed cell death selective autophagy receptors |
| url | http://www.mdpi.com/2073-4409/1/3/248 |
| work_keys_str_mv | AT ioannispnezis theselectivityandspecificityofautophagyindrosophila AT ioannispnezis selectivityandspecificityofautophagyindrosophila |