Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine
A new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/18/2/1464 |
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| author | Elene C. Pereira-Maia Edmar Chartone-Souza Mônica Bucciarelli-Rodriguez Nelson G. Fernandes Geandson C. Santos Rodinei Augusti Priscila P. Silva Marina S. Franco Ivana M. Marzano |
| author_facet | Elene C. Pereira-Maia Edmar Chartone-Souza Mônica Bucciarelli-Rodriguez Nelson G. Fernandes Geandson C. Santos Rodinei Augusti Priscila P. Silva Marina S. Franco Ivana M. Marzano |
| author_sort | Elene C. Pereira-Maia |
| collection | DOAJ |
| description | A new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and the cytotoxic activities of the compound were investigated. Elemental and conductivity analyses are in accordance to the formulation [BiCl3(C11H11N3O2S)3]. The structure of the complex reveals a distorted octahedral geometry around the bismuth atom, which is bound to three sulfonamidic nitrogens from sulfapyridine, acting as a monodentate ligand, and to three chloride ions. The presence of the compound in solution was confirmed by ESI-MS studies. The complex is 3 times more potent than the ligand against Salmonella typhimurium, 4 times against Staphylococcus aureus, Shigella dysenteriae, and Shigella sonnei and 8 times more potent against Pseudomonas aeruginosa and Escherichia coli. The compound inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 44 μM whereas the free ligand has no effect up to 100 μM. |
| first_indexed | 2024-04-13T06:00:04Z |
| format | Article |
| id | doaj.art-fbcea6abb7464d8397fa9d644da447e6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T06:00:04Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fbcea6abb7464d8397fa9d644da447e62022-12-22T02:59:28ZengMDPI AGMolecules1420-30492013-01-011821464147610.3390/molecules18021464Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with SulfapyridineElene C. Pereira-MaiaEdmar Chartone-SouzaMônica Bucciarelli-RodriguezNelson G. FernandesGeandson C. SantosRodinei AugustiPriscila P. SilvaMarina S. FrancoIvana M. MarzanoA new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and the cytotoxic activities of the compound were investigated. Elemental and conductivity analyses are in accordance to the formulation [BiCl3(C11H11N3O2S)3]. The structure of the complex reveals a distorted octahedral geometry around the bismuth atom, which is bound to three sulfonamidic nitrogens from sulfapyridine, acting as a monodentate ligand, and to three chloride ions. The presence of the compound in solution was confirmed by ESI-MS studies. The complex is 3 times more potent than the ligand against Salmonella typhimurium, 4 times against Staphylococcus aureus, Shigella dysenteriae, and Shigella sonnei and 8 times more potent against Pseudomonas aeruginosa and Escherichia coli. The compound inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 44 μM whereas the free ligand has no effect up to 100 μM.http://www.mdpi.com/1420-3049/18/2/1464Bi(III) complexsulfapyridineX-ray structureantimicrobial activitycytotoxic activity |
| spellingShingle | Elene C. Pereira-Maia Edmar Chartone-Souza Mônica Bucciarelli-Rodriguez Nelson G. Fernandes Geandson C. Santos Rodinei Augusti Priscila P. Silva Marina S. Franco Ivana M. Marzano Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine Molecules Bi(III) complex sulfapyridine X-ray structure antimicrobial activity cytotoxic activity |
| title | Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine |
| title_full | Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine |
| title_fullStr | Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine |
| title_full_unstemmed | Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine |
| title_short | Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine |
| title_sort | crystal structure antibacterial and cytotoxic activities of a new complex of bismuth iii with sulfapyridine |
| topic | Bi(III) complex sulfapyridine X-ray structure antimicrobial activity cytotoxic activity |
| url | http://www.mdpi.com/1420-3049/18/2/1464 |
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