The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia
Abstract This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical severity of knee OA. This case‒control study was performed among 100 healthy knees and 130 osteoarthritis (OA) knees of people aged ≥ 50 years with a BMI ≥ 25 kg/m2. The possible correlations among cli...
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34824-2 |
| _version_ | 1797822987772100608 |
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| author | Nicolaas C. Budhiparama Imelda Lumban-Gaol Herawati Sudoyo Rahadyan Magetsari Tri Wibawa |
| author_facet | Nicolaas C. Budhiparama Imelda Lumban-Gaol Herawati Sudoyo Rahadyan Magetsari Tri Wibawa |
| author_sort | Nicolaas C. Budhiparama |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical severity of knee OA. This case‒control study was performed among 100 healthy knees and 130 osteoarthritis (OA) knees of people aged ≥ 50 years with a BMI ≥ 25 kg/m2. The possible correlations among clinical findings, radiographic evaluations, serum levels of IL-1R1 and IL-1Ra, and genotype analyses were evaluated. Three SNPs of IL-1R1, rs871659, rs3771202, and rs3917238, were associated with primary knee OA. Females with IL-1R1 SNP rs871659 allele A had a higher prevalence of primary knee OA. No correlation was found between SNPs of IL-1R1 and IL-1RN and clinical or radiologic severity or serum concentrations of IL-1R1 and IL-1Ra (p > 0.05). BMI and IL-1R1 rs3917238 genotype C/C were correlated with moderate-severe VAS scores. A correlation was also found between the EQ-5D-3L self-care dimension and obesity and between the EQ-5D-3L pain and usual activity dimensions and age ≥ 60 and obesity (p < 0.05). Radiologic severity was only associated with age ≥ 60 years (p < 0.05). We found the IL-1R1 SNPs rs871659, rs3771202, and rs3917238 to be predisposing factors for primary knee osteoarthritis. The clinical findings, radiographic severity, and serum concentrations of IL-1R1 and IL-1Ra were not correlated with these gene polymorphisms. |
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| last_indexed | 2024-03-13T10:16:21Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-fbcf2edfdd154cd0b0902efefed0a2502023-05-21T11:13:04ZengNature PortfolioScientific Reports2045-23222023-05-0113111010.1038/s41598-023-34824-2The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in IndonesiaNicolaas C. Budhiparama0Imelda Lumban-Gaol1Herawati Sudoyo2Rahadyan Magetsari3Tri Wibawa4Department of Orthopaedic and Traumatology, Faculty of Medicine, Unversitas AirlanggaNicolaas Institute of Constructive Orthopaedics Research and Education Foundation for Arthroplaty and Sports MedicineEijkman Institute for Molecular BiologyDepartment of Orthopaedic and Traumatology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah MadaDepartment of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah MadaAbstract This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical severity of knee OA. This case‒control study was performed among 100 healthy knees and 130 osteoarthritis (OA) knees of people aged ≥ 50 years with a BMI ≥ 25 kg/m2. The possible correlations among clinical findings, radiographic evaluations, serum levels of IL-1R1 and IL-1Ra, and genotype analyses were evaluated. Three SNPs of IL-1R1, rs871659, rs3771202, and rs3917238, were associated with primary knee OA. Females with IL-1R1 SNP rs871659 allele A had a higher prevalence of primary knee OA. No correlation was found between SNPs of IL-1R1 and IL-1RN and clinical or radiologic severity or serum concentrations of IL-1R1 and IL-1Ra (p > 0.05). BMI and IL-1R1 rs3917238 genotype C/C were correlated with moderate-severe VAS scores. A correlation was also found between the EQ-5D-3L self-care dimension and obesity and between the EQ-5D-3L pain and usual activity dimensions and age ≥ 60 and obesity (p < 0.05). Radiologic severity was only associated with age ≥ 60 years (p < 0.05). We found the IL-1R1 SNPs rs871659, rs3771202, and rs3917238 to be predisposing factors for primary knee osteoarthritis. The clinical findings, radiographic severity, and serum concentrations of IL-1R1 and IL-1Ra were not correlated with these gene polymorphisms.https://doi.org/10.1038/s41598-023-34824-2 |
| spellingShingle | Nicolaas C. Budhiparama Imelda Lumban-Gaol Herawati Sudoyo Rahadyan Magetsari Tri Wibawa The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia Scientific Reports |
| title | The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia |
| title_full | The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia |
| title_fullStr | The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia |
| title_full_unstemmed | The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia |
| title_short | The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia |
| title_sort | role of genetic polymorphisms of interleukin 1 il 1r1 and il 1rn in primary knee osteoarthritis in indonesia |
| url | https://doi.org/10.1038/s41598-023-34824-2 |
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