The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia
The present study was designed to determine the possibility of the application the genotyping of the patients with dislipidaemia as an additional factor for the prediction of the cardiovascular complications. The distribution of the polymorphism C677T of the gene MTHFR among the 62 patients with dis...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Peoples’ Friendship University of Russia (RUDN University)
2012-06-01
|
| Series: | RUDN Journal of Medicine |
| Subjects: | |
| Online Access: | http://journals.rudn.ru/medicine/article/view/3104 |
| _version_ | 1819150171832844288 |
|---|---|
| author | G I Myandina E N Kasapova T U Zotova V A Frolov |
| author_facet | G I Myandina E N Kasapova T U Zotova V A Frolov |
| author_sort | G I Myandina |
| collection | DOAJ |
| description | The present study was designed to determine the possibility of the application the genotyping of the patients with dislipidaemia as an additional factor for the prediction of the cardiovascular complications. The distribution of the polymorphism C677T of the gene MTHFR among the 62 patients with dislipidaemia was studied. Allele-specific PCR was applied for detection the C677T mutation/ These results provide the genetic evidence that 677T allele of the gene MTHFR correlates with the development of the complications of the coronary heart disease for the patients with dislipidaemia (p = 0,01). It was demonstrated that more complex and durable antihypertension and cardiotropic therapy must be applicated for the carries of the 677T allele among the dislipidaemia patients. These data indicate the appreciable role C677T polymorphism of MTHFR for the decreasing of the cardiovascular complications among the patients with dislipidaemia and for detection the complexity and longevity of the medical treatments. |
| first_indexed | 2024-12-22T14:13:16Z |
| format | Article |
| id | doaj.art-fbcfabdd4c474278985db089b9149ea0 |
| institution | Directory Open Access Journal |
| issn | 2313-0245 2313-0261 |
| language | English |
| last_indexed | 2024-12-22T14:13:16Z |
| publishDate | 2012-06-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Medicine |
| spelling | doaj.art-fbcfabdd4c474278985db089b9149ea02022-12-21T18:23:10ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612012-06-010223273104The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemiaG I Myandina0E N Kasapova1T U Zotova2V A Frolov3Российский университет дружбы народовРоссийский университет дружбы народовРоссийский университет дружбы народовРоссийский университет дружбы народовThe present study was designed to determine the possibility of the application the genotyping of the patients with dislipidaemia as an additional factor for the prediction of the cardiovascular complications. The distribution of the polymorphism C677T of the gene MTHFR among the 62 patients with dislipidaemia was studied. Allele-specific PCR was applied for detection the C677T mutation/ These results provide the genetic evidence that 677T allele of the gene MTHFR correlates with the development of the complications of the coronary heart disease for the patients with dislipidaemia (p = 0,01). It was demonstrated that more complex and durable antihypertension and cardiotropic therapy must be applicated for the carries of the 677T allele among the dislipidaemia patients. These data indicate the appreciable role C677T polymorphism of MTHFR for the decreasing of the cardiovascular complications among the patients with dislipidaemia and for detection the complexity and longevity of the medical treatments.http://journals.rudn.ru/medicine/article/view/3104дислипидемияишемическая болезнь сердцагипертоническая болезньполиморфизм С677Тген MTHFR |
| spellingShingle | G I Myandina E N Kasapova T U Zotova V A Frolov The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia RUDN Journal of Medicine дислипидемия ишемическая болезнь сердца гипертоническая болезнь полиморфизм С677Т ген MTHFR |
| title | The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia |
| title_full | The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia |
| title_fullStr | The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia |
| title_full_unstemmed | The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia |
| title_short | The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia |
| title_sort | polymorphism c677t of the gene mthfr correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia |
| topic | дислипидемия ишемическая болезнь сердца гипертоническая болезнь полиморфизм С677Т ген MTHFR |
| url | http://journals.rudn.ru/medicine/article/view/3104 |
| work_keys_str_mv | AT gimyandina thepolymorphismc677tofthegenemthfrcorrelateswiththecomplicationsofthecoronaryheartdiseaseandarterialhypertensionforthepatientswithdislipidaemia AT enkasapova thepolymorphismc677tofthegenemthfrcorrelateswiththecomplicationsofthecoronaryheartdiseaseandarterialhypertensionforthepatientswithdislipidaemia AT tuzotova thepolymorphismc677tofthegenemthfrcorrelateswiththecomplicationsofthecoronaryheartdiseaseandarterialhypertensionforthepatientswithdislipidaemia AT vafrolov thepolymorphismc677tofthegenemthfrcorrelateswiththecomplicationsofthecoronaryheartdiseaseandarterialhypertensionforthepatientswithdislipidaemia AT gimyandina polymorphismc677tofthegenemthfrcorrelateswiththecomplicationsofthecoronaryheartdiseaseandarterialhypertensionforthepatientswithdislipidaemia AT enkasapova polymorphismc677tofthegenemthfrcorrelateswiththecomplicationsofthecoronaryheartdiseaseandarterialhypertensionforthepatientswithdislipidaemia AT tuzotova polymorphismc677tofthegenemthfrcorrelateswiththecomplicationsofthecoronaryheartdiseaseandarterialhypertensionforthepatientswithdislipidaemia AT vafrolov polymorphismc677tofthegenemthfrcorrelateswiththecomplicationsofthecoronaryheartdiseaseandarterialhypertensionforthepatientswithdislipidaemia |