Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1
Abstract Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which is suffered by approximately 3% of the world population. The overexpression of reactive oxygen species (ROS) plays a critical role in psoriasis progress. Here we show that biomimetic iron single-atom c...
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| Format: | Article |
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Nature Portfolio
2023-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-42477-y |
| _version_ | 1797558841198510080 |
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| author | Xiangyu Lu Le Kuai Fang Huang Jingsi Jiang Jiankun Song Yiqiong Liu Si Chen Lijie Mao Wei Peng Ying Luo Yongyong Li Haiqing Dong Bin Li Jianlin Shi |
| author_facet | Xiangyu Lu Le Kuai Fang Huang Jingsi Jiang Jiankun Song Yiqiong Liu Si Chen Lijie Mao Wei Peng Ying Luo Yongyong Li Haiqing Dong Bin Li Jianlin Shi |
| author_sort | Xiangyu Lu |
| collection | DOAJ |
| description | Abstract Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which is suffered by approximately 3% of the world population. The overexpression of reactive oxygen species (ROS) plays a critical role in psoriasis progress. Here we show that biomimetic iron single-atom catalysts (FeN4O2-SACs) with broad-spectrum ROS scavenging capability can be used for psoriasis treatment and relapse prevention via related gene restoration. FeN4O2-SACs demonstrate attractive multiple enzyme-mimicking activities based on atomically dispersed Fe active structures, which are analogous to those of natural antioxidant enzymes, iron superoxide dismutase, human erythrocyte catalase, and ascorbate peroxidase. Further, in vitro and in vivo experiments show that FeN4O2-SACs can effectively ameliorate psoriasis-like symptoms and prevent the relapse with augmented efficacy compared with the clinical drug calcipotriol. Mechanistically, estrogen receptor 1 (ESR1) is identified as the core protein upregulated in psoriasis treatment through RNA sequencing and bioinformatic analysis. Together, this study provides a proof of concept of psoriasis catalytic therapy (PCT) and multienzyme-inspired bionics (MIB). |
| first_indexed | 2024-03-10T17:36:07Z |
| format | Article |
| id | doaj.art-fbd1b2aad9714fd098bd3580f1d926ea |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:36:07Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fbd1b2aad9714fd098bd3580f1d926ea2023-11-20T09:51:32ZengNature PortfolioNature Communications2041-17232023-10-0114111510.1038/s41467-023-42477-ySingle-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1Xiangyu Lu0Le Kuai1Fang Huang2Jingsi Jiang3Jiankun Song4Yiqiong Liu5Si Chen6Lijie Mao7Wei Peng8Ying Luo9Yongyong Li10Haiqing Dong11Bin Li12Jianlin Shi13Shanghai Tenth People’s Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, Clinical Center For Brain And Spinal Cord Research, School of Medicine, Tongji UniversityDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineShanghai Tenth People’s Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, Clinical Center For Brain And Spinal Cord Research, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Tenth People’s Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, Clinical Center For Brain And Spinal Cord Research, School of Medicine, Tongji UniversityShanghai Tenth People’s Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, Clinical Center For Brain And Spinal Cord Research, School of Medicine, Tongji UniversityInstitute of Waste Treatment and Reclamation, College of Environment Science and Engineering, Tongji UniversityDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital, School of Medicine, Tongji UniversityInstitute of Dermatology, Shanghai Academy of Traditional Chinese MedicineShanghai Tenth People’s Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, Clinical Center For Brain And Spinal Cord Research, School of Medicine, Tongji UniversityAbstract Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which is suffered by approximately 3% of the world population. The overexpression of reactive oxygen species (ROS) plays a critical role in psoriasis progress. Here we show that biomimetic iron single-atom catalysts (FeN4O2-SACs) with broad-spectrum ROS scavenging capability can be used for psoriasis treatment and relapse prevention via related gene restoration. FeN4O2-SACs demonstrate attractive multiple enzyme-mimicking activities based on atomically dispersed Fe active structures, which are analogous to those of natural antioxidant enzymes, iron superoxide dismutase, human erythrocyte catalase, and ascorbate peroxidase. Further, in vitro and in vivo experiments show that FeN4O2-SACs can effectively ameliorate psoriasis-like symptoms and prevent the relapse with augmented efficacy compared with the clinical drug calcipotriol. Mechanistically, estrogen receptor 1 (ESR1) is identified as the core protein upregulated in psoriasis treatment through RNA sequencing and bioinformatic analysis. Together, this study provides a proof of concept of psoriasis catalytic therapy (PCT) and multienzyme-inspired bionics (MIB).https://doi.org/10.1038/s41467-023-42477-y |
| spellingShingle | Xiangyu Lu Le Kuai Fang Huang Jingsi Jiang Jiankun Song Yiqiong Liu Si Chen Lijie Mao Wei Peng Ying Luo Yongyong Li Haiqing Dong Bin Li Jianlin Shi Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1 Nature Communications |
| title | Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1 |
| title_full | Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1 |
| title_fullStr | Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1 |
| title_full_unstemmed | Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1 |
| title_short | Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1 |
| title_sort | single atom catalysts based catalytic ros clearance for efficient psoriasis treatment and relapse prevention via restoring esr1 |
| url | https://doi.org/10.1038/s41467-023-42477-y |
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