The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?
Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/466 |
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| author | Peter Takáč Radka Michalková Martina Čižmáriková Zdenka Bedlovičová Ľudmila Balážová Gabriela Takáčová |
| author_facet | Peter Takáč Radka Michalková Martina Čižmáriková Zdenka Bedlovičová Ľudmila Balážová Gabriela Takáčová |
| author_sort | Peter Takáč |
| collection | DOAJ |
| description | Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on the development of a modernistic field called nano-oncology, which provides the possibility of using nanoparticles (NPs) with the aim to detect, target, and treat cancer diseases. In comparison with conventional anticancer strategies, NPs provide a targeted approach, preventing undesirable side effects. What is more, nanoparticle-based drug delivery systems have shown good pharmacokinetics and precise targeting, as well as reduced multidrug resistance. It has been documented that, in cancer cells, NPs promote reactive oxygen species (ROS) production, induce cell cycle arrest and apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability to inhibit tumor growth in vivo has also been documented. In this paper, we have reviewed the role of silver NPs (AgNPs) in cancer nanomedicine, discussing numerous mechanisms by which they render anticancer properties under both in vitro and in vivo conditions, as well as their potential in the diagnosis of cancer. |
| first_indexed | 2024-03-11T08:33:07Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:33:07Z |
| publishDate | 2023-02-01 |
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| record_format | Article |
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| spelling | doaj.art-fbd286dd2c8a40a9b5f3dcaeb4f6f3842023-11-16T21:41:39ZengMDPI AGLife2075-17292023-02-0113246610.3390/life13020466The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?Peter Takáč0Radka Michalková1Martina Čižmáriková2Zdenka Bedlovičová3Ľudmila Balážová4Gabriela Takáčová5Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, SlovakiaDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Kosice, SlovakiaDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Kosice, SlovakiaDepartment of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, SlovakiaDepartment of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy in Košice, 041 81 Košice, SlovakiaDepartment of Dermatovenerology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, SlovakiaCancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on the development of a modernistic field called nano-oncology, which provides the possibility of using nanoparticles (NPs) with the aim to detect, target, and treat cancer diseases. In comparison with conventional anticancer strategies, NPs provide a targeted approach, preventing undesirable side effects. What is more, nanoparticle-based drug delivery systems have shown good pharmacokinetics and precise targeting, as well as reduced multidrug resistance. It has been documented that, in cancer cells, NPs promote reactive oxygen species (ROS) production, induce cell cycle arrest and apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability to inhibit tumor growth in vivo has also been documented. In this paper, we have reviewed the role of silver NPs (AgNPs) in cancer nanomedicine, discussing numerous mechanisms by which they render anticancer properties under both in vitro and in vivo conditions, as well as their potential in the diagnosis of cancer.https://www.mdpi.com/2075-1729/13/2/466silvernanomedicineantitumor mechanismscancer therapycancer diagnosis |
| spellingShingle | Peter Takáč Radka Michalková Martina Čižmáriková Zdenka Bedlovičová Ľudmila Balážová Gabriela Takáčová The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? Life silver nanomedicine antitumor mechanisms cancer therapy cancer diagnosis |
| title | The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? |
| title_full | The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? |
| title_fullStr | The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? |
| title_full_unstemmed | The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? |
| title_short | The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? |
| title_sort | role of silver nanoparticles in the diagnosis and treatment of cancer are there any perspectives for the future |
| topic | silver nanomedicine antitumor mechanisms cancer therapy cancer diagnosis |
| url | https://www.mdpi.com/2075-1729/13/2/466 |
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