Lignan Glycosides from <i>Urena lobata</i>
Four new lignan glycosides; urenalignosides A−D (<b>1</b>−<b>4</b>), along with 12 known ones (<b>5</b>−<b>16</b>) were isolated from <i>Urena lobata</i>. Their structures were determined on the basis of extens...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/15/2850 |
| _version_ | 1819118649716244480 |
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| author | Yuan Luo Cong Su Ning Ding Bowen Qi Fangfang Jia Xiping Xu Xiao Liu Juan Wang Xiaohui Wang Pengfei Tu Shepo Shi |
| author_facet | Yuan Luo Cong Su Ning Ding Bowen Qi Fangfang Jia Xiping Xu Xiao Liu Juan Wang Xiaohui Wang Pengfei Tu Shepo Shi |
| author_sort | Yuan Luo |
| collection | DOAJ |
| description | Four new lignan glycosides; urenalignosides A−D (<b>1</b>−<b>4</b>), along with 12 known ones (<b>5</b>−<b>16</b>) were isolated from <i>Urena lobata</i>. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds <b>2</b>−<b>4</b>; <b>6</b>; <b>7</b>; <b>10</b>; and <b>11</b> showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC<sub>50</sub> values in the range of 25.5−98.4 μM (positive control; quercetin; IC<sub>50</sub> = 7.2 ± 0.2 μM). |
| first_indexed | 2024-12-22T05:52:14Z |
| format | Article |
| id | doaj.art-fbd3658ea811490c98ba17e371b36106 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T05:52:14Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fbd3658ea811490c98ba17e371b361062022-12-21T18:36:50ZengMDPI AGMolecules1420-30492019-08-012415285010.3390/molecules24152850molecules24152850Lignan Glycosides from <i>Urena lobata</i>Yuan Luo0Cong Su1Ning Ding2Bowen Qi3Fangfang Jia4Xiping Xu5Xiao Liu6Juan Wang7Xiaohui Wang8Pengfei Tu9Shepo Shi10Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, ChinaFour new lignan glycosides; urenalignosides A−D (<b>1</b>−<b>4</b>), along with 12 known ones (<b>5</b>−<b>16</b>) were isolated from <i>Urena lobata</i>. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds <b>2</b>−<b>4</b>; <b>6</b>; <b>7</b>; <b>10</b>; and <b>11</b> showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC<sub>50</sub> values in the range of 25.5−98.4 μM (positive control; quercetin; IC<sub>50</sub> = 7.2 ± 0.2 μM).https://www.mdpi.com/1420-3049/24/15/2850<i>Urena lobata</i> L.lignan glycosidesurenalignosides A–Dnitric oxide production |
| spellingShingle | Yuan Luo Cong Su Ning Ding Bowen Qi Fangfang Jia Xiping Xu Xiao Liu Juan Wang Xiaohui Wang Pengfei Tu Shepo Shi Lignan Glycosides from <i>Urena lobata</i> Molecules <i>Urena lobata</i> L. lignan glycosides urenalignosides A–D nitric oxide production |
| title | Lignan Glycosides from <i>Urena lobata</i> |
| title_full | Lignan Glycosides from <i>Urena lobata</i> |
| title_fullStr | Lignan Glycosides from <i>Urena lobata</i> |
| title_full_unstemmed | Lignan Glycosides from <i>Urena lobata</i> |
| title_short | Lignan Glycosides from <i>Urena lobata</i> |
| title_sort | lignan glycosides from i urena lobata i |
| topic | <i>Urena lobata</i> L. lignan glycosides urenalignosides A–D nitric oxide production |
| url | https://www.mdpi.com/1420-3049/24/15/2850 |
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