The effect of natural products on inflammatory cytokines production and secretion
Background: The human body is regulated by the controlled production and secretion of thousands of chemicals, including polypeptides called cytokines. Cytokines play crucial roles in the immune system reaction following tissue injury and/or body invasion by infectious or non-infectious bodies. They...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-11-01
|
| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031323000842 |
| _version_ | 1797627145227337728 |
|---|---|
| author | Muna Barakat Nabeel Kashan Syed Eliza Hasen Shaymaa B. Abdulrazzaq Samar Thiab Mohammad A.A. Al-Najjar Amin Omar Tanzima Tarannum Lucy A.N.M. Mamun-Or-Rashid Masayuki Yagi Yoshikazu Yonei |
| author_facet | Muna Barakat Nabeel Kashan Syed Eliza Hasen Shaymaa B. Abdulrazzaq Samar Thiab Mohammad A.A. Al-Najjar Amin Omar Tanzima Tarannum Lucy A.N.M. Mamun-Or-Rashid Masayuki Yagi Yoshikazu Yonei |
| author_sort | Muna Barakat |
| collection | DOAJ |
| description | Background: The human body is regulated by the controlled production and secretion of thousands of chemicals, including polypeptides called cytokines. Cytokines play crucial roles in the immune system reaction following tissue injury and/or body invasion by infectious or non-infectious bodies. They are classified as pro and anti-inflammatory cytokines depending on many factors such as structure and function. Some cytokines mediate inflammatory reactions and contribute to several diseases, such as Rheumatoid arthritis. Very few effective treatment strategies exist to tackle these inflammatory diseases and the available strategies for treatment are also associated with several severe side effects. Although we are in the scientific innovations and medical advancements era, natural compounds are still competing with modern artificial drugs and performing well to effectively treat many diseases without causing side effects. The main purpose of this review is to discuss the effect of some natural compounds on inflammatory cytokine production and elaborate their mode of action further based on already available and recently published literature. Methods: We have reviewed a selected number of natural compounds (Echinacea, Curcumin, Genistein, Eugenol, 6-Gingerol, Thymoquinone, Allicin, Quercetin, Emodin and Parthenolide) that have shown pronounced effects on cytokine production and secretion in several physiological conditions. Findings and Conclusion: Immune cells produce multiple pro-inflammatory and anti-inflammatory cytokines that could be regulated accurately and effectively by using some natural compounds that can block the intracellular machinery and thus reduce cytokine production and secretion. This offers an intriguing background for grasping how these products conduct their activity at a cellular level and sheds light on other natural products to examine efficiency in the same aspect. |
| first_indexed | 2024-03-11T10:20:13Z |
| format | Article |
| id | doaj.art-fbd368fdb0d44683916b7bcfc57e6ec1 |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-03-11T10:20:13Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-fbd368fdb0d44683916b7bcfc57e6ec12023-11-16T06:11:11ZengElsevierPhytomedicine Plus2667-03132023-11-0134100488The effect of natural products on inflammatory cytokines production and secretionMuna Barakat0Nabeel Kashan Syed1Eliza Hasen2Shaymaa B. Abdulrazzaq3Samar Thiab4Mohammad A.A. Al-Najjar5Amin Omar6Tanzima Tarannum Lucy7A.N.M. Mamun-Or-Rashid8Masayuki Yagi9Yoshikazu Yonei10Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan; MEU Research Unit, Middle East, University, Amman, Jordan; Corresponding author at: Department of Clinical Pharmacy & Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.Pharmacy Practice Research Unit, Department of Clinical Pharmacy, Faculty of Pharmacy, Jazan University, Gizan, Kingdom of Saudi ArabiaMEU Research Unit, Middle East, University, Amman, JordanDepartment of Pharmaceutics and Pharmaceutical Sciences, Faculty of Pharmacy, Applied Science Private University, Amman, JordanDepartment of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Science Private University, Amman, JordanDepartment of Pharmaceutics and Pharmaceutical Sciences, Faculty of Pharmacy, Applied Science Private University, Amman, JordanDepartment of Pharmaceutics and Pharmaceutical Sciences, Faculty of Pharmacy, Applied Science Private University, Amman, JordanAnti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan; Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, JapanAnti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan; Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan; Department of Environmental & Occupational Health, School of Public Health, University of Pittsburgh, 130 De Soto Str. Pittsburgh, PA, 15261, United States of AmericaAnti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan; Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, JapanAnti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan; Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, JapanBackground: The human body is regulated by the controlled production and secretion of thousands of chemicals, including polypeptides called cytokines. Cytokines play crucial roles in the immune system reaction following tissue injury and/or body invasion by infectious or non-infectious bodies. They are classified as pro and anti-inflammatory cytokines depending on many factors such as structure and function. Some cytokines mediate inflammatory reactions and contribute to several diseases, such as Rheumatoid arthritis. Very few effective treatment strategies exist to tackle these inflammatory diseases and the available strategies for treatment are also associated with several severe side effects. Although we are in the scientific innovations and medical advancements era, natural compounds are still competing with modern artificial drugs and performing well to effectively treat many diseases without causing side effects. The main purpose of this review is to discuss the effect of some natural compounds on inflammatory cytokine production and elaborate their mode of action further based on already available and recently published literature. Methods: We have reviewed a selected number of natural compounds (Echinacea, Curcumin, Genistein, Eugenol, 6-Gingerol, Thymoquinone, Allicin, Quercetin, Emodin and Parthenolide) that have shown pronounced effects on cytokine production and secretion in several physiological conditions. Findings and Conclusion: Immune cells produce multiple pro-inflammatory and anti-inflammatory cytokines that could be regulated accurately and effectively by using some natural compounds that can block the intracellular machinery and thus reduce cytokine production and secretion. This offers an intriguing background for grasping how these products conduct their activity at a cellular level and sheds light on other natural products to examine efficiency in the same aspect.http://www.sciencedirect.com/science/article/pii/S2667031323000842CytokinesInflammationNatural compoundsCytokine trafficking |
| spellingShingle | Muna Barakat Nabeel Kashan Syed Eliza Hasen Shaymaa B. Abdulrazzaq Samar Thiab Mohammad A.A. Al-Najjar Amin Omar Tanzima Tarannum Lucy A.N.M. Mamun-Or-Rashid Masayuki Yagi Yoshikazu Yonei The effect of natural products on inflammatory cytokines production and secretion Phytomedicine Plus Cytokines Inflammation Natural compounds Cytokine trafficking |
| title | The effect of natural products on inflammatory cytokines production and secretion |
| title_full | The effect of natural products on inflammatory cytokines production and secretion |
| title_fullStr | The effect of natural products on inflammatory cytokines production and secretion |
| title_full_unstemmed | The effect of natural products on inflammatory cytokines production and secretion |
| title_short | The effect of natural products on inflammatory cytokines production and secretion |
| title_sort | effect of natural products on inflammatory cytokines production and secretion |
| topic | Cytokines Inflammation Natural compounds Cytokine trafficking |
| url | http://www.sciencedirect.com/science/article/pii/S2667031323000842 |
| work_keys_str_mv | AT munabarakat theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT nabeelkashansyed theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT elizahasen theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT shaymaababdulrazzaq theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT samarthiab theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT mohammadaaalnajjar theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT aminomar theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT tanzimatarannumlucy theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT anmmamunorrashid theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT masayukiyagi theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT yoshikazuyonei theeffectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT munabarakat effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT nabeelkashansyed effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT elizahasen effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT shaymaababdulrazzaq effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT samarthiab effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT mohammadaaalnajjar effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT aminomar effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT tanzimatarannumlucy effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT anmmamunorrashid effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT masayukiyagi effectofnaturalproductsoninflammatorycytokinesproductionandsecretion AT yoshikazuyonei effectofnaturalproductsoninflammatorycytokinesproductionandsecretion |