The endothelium: gatekeeper to lung ischemia-reperfusion injury

The endothelium: gatekeeper to lung ischemia-reperfusion injury

Abstract The success of lung transplantation is limited by the high rate of primary graft dysfunction due to ischemia-reperfusion injury (IRI). Lung IRI is characterized by a robust inflammatory response, lung dysfunction, endothelial barrier disruption, oxidative stress, vascular permeability, edem...

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Bibliographic Details
Main Authors: Huy Q. Ta, Maniselvan Kuppusamy, Swapnil K. Sonkusare, Mark E. Roeser, Victor E. Laubach
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Respiratory Research
Subjects:
Endothelial barrier dysfunction
Ischemia-reperfusion injury
Lung transplantation
Glycocalyx
Ion channels
TRPV4
Online Access:https://doi.org/10.1186/s12931-024-02776-4

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