Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review
Abstract Background Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease that responds poorly to treatment, with a large proportion of patients progressing to end-stage renal disease in spite of initial aggressive treatment. It is worth emphasizing that the FSGS group has still...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-09-01
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| Series: | Egyptian Pediatric Association Gazette |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43054-022-00117-y |
| _version_ | 1811211756721143808 |
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| author | Phuong Anh Le Thy Thuy Yen Hoang Thi Kiem Hao Tran Huu Son Nguyen |
| author_facet | Phuong Anh Le Thy Thuy Yen Hoang Thi Kiem Hao Tran Huu Son Nguyen |
| author_sort | Phuong Anh Le Thy |
| collection | DOAJ |
| description | Abstract Background Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease that responds poorly to treatment, with a large proportion of patients progressing to end-stage renal disease in spite of initial aggressive treatment. It is worth emphasizing that the FSGS group has still a high recurrence rate after kidney transplantation. Therefore, understanding the factors involved in the pathogenesis of FSGS will help nephrologists better understand the pathogenesis as well as find out specific targeted therapies. Circulating immune factors have long been implicated in the pathogenesis of FSGS, and recent studies have suggested that soluble urokinase plasminogen activator receptor (suPAR) is one of the good candidates for this hypothesis. The aim of this review study was to analyze the value of suPAR in glomerular disease, especially in clinical studies. Methods In this review study, the PubMed database was searched using relevant keywords (suPAR, circulating permeability factors Children, FSGS, and children). Descriptive and cross-sectional studies were reviewed in the current study with the main focuses on the role of suPAR in FSGS, nephrotic syndrome, and the relation to progression of renal failure, especially the research in children. Results Overall, 32 studies from different countries were selected. These clinical studies on suPAR have shown the following: (i) the role of suPAR in the diagnosis of FSGS has not yet been confirmed, and (ii) there is strong evidence demonstrating a significant relationship between suPAR and the severity of kidney disease as well as a high value of suPAR in predicting the steroid responsiveness of nephrotic syndrome. Conclusion Researching on circulating permeability factors in FSGS is a current trend, which opens new avenues in targeted diagnosis and treatment. suPAR is a promising candidate, and urinary suPAR has also shown advantages over serum suPAR; therefore, more research on this issue is needed in the future. |
| first_indexed | 2024-04-12T05:17:37Z |
| format | Article |
| id | doaj.art-fbd3e9cbed904844929f06d47abdb5b6 |
| institution | Directory Open Access Journal |
| issn | 2090-9942 |
| language | English |
| last_indexed | 2024-04-12T05:17:37Z |
| publishDate | 2022-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Pediatric Association Gazette |
| spelling | doaj.art-fbd3e9cbed904844929f06d47abdb5b62022-12-22T03:46:35ZengSpringerOpenEgyptian Pediatric Association Gazette2090-99422022-09-017011910.1186/s43054-022-00117-ySoluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative reviewPhuong Anh Le Thy0Thuy Yen Hoang Thi1Kiem Hao Tran2Huu Son Nguyen3Pediatric Department, Hue University of Medicine and Pharmacy, Hue UniversityPediatric Department, Hue University of Medicine and Pharmacy, Hue UniversityPediatric Center, Hue Central HospitalPediatric Center, Hue Central HospitalAbstract Background Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease that responds poorly to treatment, with a large proportion of patients progressing to end-stage renal disease in spite of initial aggressive treatment. It is worth emphasizing that the FSGS group has still a high recurrence rate after kidney transplantation. Therefore, understanding the factors involved in the pathogenesis of FSGS will help nephrologists better understand the pathogenesis as well as find out specific targeted therapies. Circulating immune factors have long been implicated in the pathogenesis of FSGS, and recent studies have suggested that soluble urokinase plasminogen activator receptor (suPAR) is one of the good candidates for this hypothesis. The aim of this review study was to analyze the value of suPAR in glomerular disease, especially in clinical studies. Methods In this review study, the PubMed database was searched using relevant keywords (suPAR, circulating permeability factors Children, FSGS, and children). Descriptive and cross-sectional studies were reviewed in the current study with the main focuses on the role of suPAR in FSGS, nephrotic syndrome, and the relation to progression of renal failure, especially the research in children. Results Overall, 32 studies from different countries were selected. These clinical studies on suPAR have shown the following: (i) the role of suPAR in the diagnosis of FSGS has not yet been confirmed, and (ii) there is strong evidence demonstrating a significant relationship between suPAR and the severity of kidney disease as well as a high value of suPAR in predicting the steroid responsiveness of nephrotic syndrome. Conclusion Researching on circulating permeability factors in FSGS is a current trend, which opens new avenues in targeted diagnosis and treatment. suPAR is a promising candidate, and urinary suPAR has also shown advantages over serum suPAR; therefore, more research on this issue is needed in the future.https://doi.org/10.1186/s43054-022-00117-yPermeabilityGlomerulosclerosisFocal segmental |
| spellingShingle | Phuong Anh Le Thy Thuy Yen Hoang Thi Kiem Hao Tran Huu Son Nguyen Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review Egyptian Pediatric Association Gazette Permeability Glomerulosclerosis Focal segmental |
| title | Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review |
| title_full | Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review |
| title_fullStr | Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review |
| title_full_unstemmed | Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review |
| title_short | Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review |
| title_sort | soluble urokinase plasminogen activator receptor supar and glomerular disease in children a narrative review |
| topic | Permeability Glomerulosclerosis Focal segmental |
| url | https://doi.org/10.1186/s43054-022-00117-y |
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