Curcumin improves liver damage in male mice exposed to nicotine
The color of turmeric (薑黃 jiāng huáng) is because of a substance called curcumin. It has different pharmacological effects, such as antioxidant and anti-inflammatory properties. Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in the liver and cause...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | Journal of Traditional and Complementary Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411014000480 |
| _version_ | 1828779840699891712 |
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| author | Mohammadreza Salahshoor Sabah Mohamadian Seyran Kakabaraei Shiva Roshankhah Cyrus Jalili |
| author_facet | Mohammadreza Salahshoor Sabah Mohamadian Seyran Kakabaraei Shiva Roshankhah Cyrus Jalili |
| author_sort | Mohammadreza Salahshoor |
| collection | DOAJ |
| description | The color of turmeric (薑黃 jiāng huáng) is because of a substance called curcumin. It has different pharmacological effects, such as antioxidant and anti-inflammatory properties. Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in the liver and causes devastating effects. This study was designed to evaluate the protective role of curcumin against nicotine on the liver in mice.
Forty-eight mice were equally divided into eight groups; control (normal saline), nicotine (2.5 mg/kg), curcumin (10, 30, and 60 mg/kg) and curcumin plus nicotine-treated groups. Curcumin, nicotine, and curcumin plus nicotine (once a day) were intraperitoneally injected for 4 weeks. The liver weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied.
The results indicated that nicotine administration significantly decreased liver weight and increased the mean diameter of hepatocyte, central hepatic vein, liver enzymes level, and blood serum nitric oxide level compared with the saline group (p < 0.05). However, curcumin and curcumin plus nicotine administration substantially increased liver weight and decreased the mean diameter of hepatocyte, central hepatic vein, liver enzymes, and nitric oxide levels in all groups compared with the nicotine group (p < 0.05).
Curcumin demonstrated its protective effect against nicotine-induced liver toxicity. |
| first_indexed | 2024-12-11T17:08:41Z |
| format | Article |
| id | doaj.art-fbd4c87775b4417d97d4d0ce88cb8915 |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-12-11T17:08:41Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-fbd4c87775b4417d97d4d0ce88cb89152022-12-22T00:57:36ZengElsevierJournal of Traditional and Complementary Medicine2225-41102016-04-016217618310.1016/j.jtcme.2014.11.034Curcumin improves liver damage in male mice exposed to nicotineMohammadreza Salahshoor0Sabah Mohamadian1Seyran Kakabaraei2Shiva Roshankhah3Cyrus Jalili4Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, IranStudent of medicine, Kermanshah University of Medical Sciences, Kermanshah, IranAnatomy Department, Kermanshah University of Medical Sciences, Kermanshah, IranFertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, IranFertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, IranThe color of turmeric (薑黃 jiāng huáng) is because of a substance called curcumin. It has different pharmacological effects, such as antioxidant and anti-inflammatory properties. Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in the liver and causes devastating effects. This study was designed to evaluate the protective role of curcumin against nicotine on the liver in mice. Forty-eight mice were equally divided into eight groups; control (normal saline), nicotine (2.5 mg/kg), curcumin (10, 30, and 60 mg/kg) and curcumin plus nicotine-treated groups. Curcumin, nicotine, and curcumin plus nicotine (once a day) were intraperitoneally injected for 4 weeks. The liver weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied. The results indicated that nicotine administration significantly decreased liver weight and increased the mean diameter of hepatocyte, central hepatic vein, liver enzymes level, and blood serum nitric oxide level compared with the saline group (p < 0.05). However, curcumin and curcumin plus nicotine administration substantially increased liver weight and decreased the mean diameter of hepatocyte, central hepatic vein, liver enzymes, and nitric oxide levels in all groups compared with the nicotine group (p < 0.05). Curcumin demonstrated its protective effect against nicotine-induced liver toxicity.http://www.sciencedirect.com/science/article/pii/S2225411014000480curcumindamagelivermicenicotine |
| spellingShingle | Mohammadreza Salahshoor Sabah Mohamadian Seyran Kakabaraei Shiva Roshankhah Cyrus Jalili Curcumin improves liver damage in male mice exposed to nicotine Journal of Traditional and Complementary Medicine curcumin damage liver mice nicotine |
| title | Curcumin improves liver damage in male mice exposed to nicotine |
| title_full | Curcumin improves liver damage in male mice exposed to nicotine |
| title_fullStr | Curcumin improves liver damage in male mice exposed to nicotine |
| title_full_unstemmed | Curcumin improves liver damage in male mice exposed to nicotine |
| title_short | Curcumin improves liver damage in male mice exposed to nicotine |
| title_sort | curcumin improves liver damage in male mice exposed to nicotine |
| topic | curcumin damage liver mice nicotine |
| url | http://www.sciencedirect.com/science/article/pii/S2225411014000480 |
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