Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression
This study aimed to investigate the effects of capsaicin on invasion and metastasis of esophageal squamous cell carcinoma (ESCC) and the underlining mechanisms. Cldn3 expression was detected in cancerous and adjacent normal esophageal tissues. The association of Cldn3 with clinical data was analyzed...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000044 |
| _version_ | 1798031309064372224 |
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| author | Ji Feng Yin Xu Zhouling Wei Yiju Xia Haoxiang Zhang Caifei Shen Pu Wang Wu Yan Dianchun Fang Yu Fang |
| author_facet | Ji Feng Yin Xu Zhouling Wei Yiju Xia Haoxiang Zhang Caifei Shen Pu Wang Wu Yan Dianchun Fang Yu Fang |
| author_sort | Ji Feng |
| collection | DOAJ |
| description | This study aimed to investigate the effects of capsaicin on invasion and metastasis of esophageal squamous cell carcinoma (ESCC) and the underlining mechanisms. Cldn3 expression was detected in cancerous and adjacent normal esophageal tissues. The association of Cldn3 with clinical data was analyzed. The migration and invasion of ESCC cells was investigated by exposing to capsaicin or with CLDN3 silencing or Cldn3 overexpression. The effects of capsaicin on lung metastasis were evaluated. Cldn3 expression in ESCC was associated with better prognosis. Capsaicin attenuated migration, invasion, and metastasis of ESCC and inhibited epithelial-mesenchymal transition (EMT) in a dose-dependent manner. Cldn3 overexpression, like exposing to capsaicin, inhibited migration, invasion and EMT, and vice versa. CLDN3 silencing attenuated inhibition of migration and invasion and EMT by exposing to capsaicin. In conclusion, Cldn3 showed a better prognosis in ESCC. Capsaicin might inhibit migration and invasion and metastasis of ESCC via overexpression of Cldn3 and inhibiting EMT. |
| first_indexed | 2024-04-11T19:54:19Z |
| format | Article |
| id | doaj.art-fbd4d3251b4e467baf03d807301a66b6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T19:54:19Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-fbd4d3251b4e467baf03d807301a66b62022-12-22T04:06:12ZengElsevierJournal of Functional Foods1756-46462022-02-0189104934Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expressionJi Feng0Yin Xu1Zhouling Wei2Yiju Xia3Haoxiang Zhang4Caifei Shen5Pu Wang6Wu Yan7Dianchun Fang8Yu Fang9Department of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, China; Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang 110840, ChinaDepartment of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, ChinaDepartment of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, ChinaDepartment of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, ChinaDepartment of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, ChinaDepartment of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, ChinaDepartment of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, ChinaDepartment of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, ChinaDepartment of Gastroenterology, Southwest Hospital, The Army Medical University, Chongqing 400038, China; Corresponding authors at: No.1 Friendship Road, Yu Zhong District, Chongqing 400016, China.Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Corresponding authors at: No.1 Friendship Road, Yu Zhong District, Chongqing 400016, China.This study aimed to investigate the effects of capsaicin on invasion and metastasis of esophageal squamous cell carcinoma (ESCC) and the underlining mechanisms. Cldn3 expression was detected in cancerous and adjacent normal esophageal tissues. The association of Cldn3 with clinical data was analyzed. The migration and invasion of ESCC cells was investigated by exposing to capsaicin or with CLDN3 silencing or Cldn3 overexpression. The effects of capsaicin on lung metastasis were evaluated. Cldn3 expression in ESCC was associated with better prognosis. Capsaicin attenuated migration, invasion, and metastasis of ESCC and inhibited epithelial-mesenchymal transition (EMT) in a dose-dependent manner. Cldn3 overexpression, like exposing to capsaicin, inhibited migration, invasion and EMT, and vice versa. CLDN3 silencing attenuated inhibition of migration and invasion and EMT by exposing to capsaicin. In conclusion, Cldn3 showed a better prognosis in ESCC. Capsaicin might inhibit migration and invasion and metastasis of ESCC via overexpression of Cldn3 and inhibiting EMT.http://www.sciencedirect.com/science/article/pii/S1756464622000044Esophageal squamous cell carcinomaClaudin 3CapsaicinEpithelial-mesenchymal transitionInvasion and migrationLymph node metastasis |
| spellingShingle | Ji Feng Yin Xu Zhouling Wei Yiju Xia Haoxiang Zhang Caifei Shen Pu Wang Wu Yan Dianchun Fang Yu Fang Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression Journal of Functional Foods Esophageal squamous cell carcinoma Claudin 3 Capsaicin Epithelial-mesenchymal transition Invasion and migration Lymph node metastasis |
| title | Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression |
| title_full | Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression |
| title_fullStr | Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression |
| title_full_unstemmed | Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression |
| title_short | Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression |
| title_sort | capsaicin inhibits migration and invasion via inhibiting epithelial mesenchymal transition in esophageal squamous cell carcinoma by up regulation of claudin 3 expression |
| topic | Esophageal squamous cell carcinoma Claudin 3 Capsaicin Epithelial-mesenchymal transition Invasion and migration Lymph node metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000044 |
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