Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplas...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00758-3 |
| _version_ | 1818857977880248320 |
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| author | Iwei Yeh Ursula E. Lang Emeline Durieux Meng Kian Tee Aparna Jorapur A. Hunter Shain Veronique Haddad Daniel Pissaloux Xu Chen Lorenzo Cerroni Robert L. Judson Philip E. LeBoit Timothy H. McCalmont Boris C. Bastian Arnaud de la Fouchardière |
| author_facet | Iwei Yeh Ursula E. Lang Emeline Durieux Meng Kian Tee Aparna Jorapur A. Hunter Shain Veronique Haddad Daniel Pissaloux Xu Chen Lorenzo Cerroni Robert L. Judson Philip E. LeBoit Timothy H. McCalmont Boris C. Bastian Arnaud de la Fouchardière |
| author_sort | Iwei Yeh |
| collection | DOAJ |
| description | Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplasms. |
| first_indexed | 2024-12-19T08:48:58Z |
| format | Article |
| id | doaj.art-fbd6a7307720476793d06dd7588353f5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:48:58Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fbd6a7307720476793d06dd7588353f52022-12-21T20:28:48ZengNature PortfolioNature Communications2041-17232017-09-01811810.1038/s41467-017-00758-3Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating neviIwei Yeh0Ursula E. Lang1Emeline Durieux2Meng Kian Tee3Aparna Jorapur4A. Hunter Shain5Veronique Haddad6Daniel Pissaloux7Xu Chen8Lorenzo Cerroni9Robert L. Judson10Philip E. LeBoit11Timothy H. McCalmont12Boris C. Bastian13Arnaud de la Fouchardière14Department of Dermatology, University of CaliforniaDepartment of Pathology, University of CaliforniaDepartment of Pathology, Centre Hospitalier Lyon-SudDepartment of Dermatology, University of CaliforniaDepartment of Dermatology, University of CaliforniaDepartment of Dermatology, University of CaliforniaDepartment of Biopathology, Centre Léon BérardDepartment of Biopathology, Centre Léon BérardDepartment of Dermatology, University of CaliforniaDepartment of Dermatology, Medical University of GrazDepartment of Dermatology, University of CaliforniaDepartment of Dermatology, University of CaliforniaDepartment of Dermatology, University of CaliforniaDepartment of Dermatology, University of CaliforniaDepartment of Biopathology, Centre Léon BérardDeep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplasms.https://doi.org/10.1038/s41467-017-00758-3 |
| spellingShingle | Iwei Yeh Ursula E. Lang Emeline Durieux Meng Kian Tee Aparna Jorapur A. Hunter Shain Veronique Haddad Daniel Pissaloux Xu Chen Lorenzo Cerroni Robert L. Judson Philip E. LeBoit Timothy H. McCalmont Boris C. Bastian Arnaud de la Fouchardière Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi Nature Communications |
| title | Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi |
| title_full | Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi |
| title_fullStr | Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi |
| title_full_unstemmed | Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi |
| title_short | Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi |
| title_sort | combined activation of map kinase pathway and β catenin signaling cause deep penetrating nevi |
| url | https://doi.org/10.1038/s41467-017-00758-3 |
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