A curated catalog of canine and equine keratin genes.
Keratins represent a large protein family with essential structural and functional roles in epithelial cells of skin, hair follicles, and other organs. During evolution the genes encoding keratins have undergone multiple rounds of duplication and humans have two clusters with a total of 55 functiona...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5573215?pdf=render |
| _version_ | 1830482665144320000 |
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| author | Pierre Balmer Anina Bauer Shashikant Pujar Kelly M McGarvey Monika Welle Arnaud Galichet Eliane J Müller Kim D Pruitt Tosso Leeb Vidhya Jagannathan |
| author_facet | Pierre Balmer Anina Bauer Shashikant Pujar Kelly M McGarvey Monika Welle Arnaud Galichet Eliane J Müller Kim D Pruitt Tosso Leeb Vidhya Jagannathan |
| author_sort | Pierre Balmer |
| collection | DOAJ |
| description | Keratins represent a large protein family with essential structural and functional roles in epithelial cells of skin, hair follicles, and other organs. During evolution the genes encoding keratins have undergone multiple rounds of duplication and humans have two clusters with a total of 55 functional keratin genes in their genomes. Due to the high similarity between different keratin paralogs and species-specific differences in gene content, the currently available keratin gene annotation in species with draft genome assemblies such as dog and horse is still imperfect. We compared the National Center for Biotechnology Information (NCBI) (dog annotation release 103, horse annotation release 101) and Ensembl (release 87) gene predictions for the canine and equine keratin gene clusters to RNA-seq data that were generated from adult skin of five dogs and two horses and from adult hair follicle tissue of one dog. Taking into consideration the knowledge on the conserved exon/intron structure of keratin genes, we annotated 61 putatively functional keratin genes in both the dog and horse, respectively. Subsequently, curators in the RefSeq group at NCBI reviewed their annotation of keratin genes in the dog and horse genomes (Annotation Release 104 and Annotation Release 102, respectively) and updated annotation and gene nomenclature of several keratin genes. The updates are now available in the NCBI Gene database (https://www.ncbi.nlm.nih.gov/gene). |
| first_indexed | 2024-12-21T17:37:52Z |
| format | Article |
| id | doaj.art-fbd6ad78bc464dc290ccb474f76ff090 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T17:37:52Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fbd6ad78bc464dc290ccb474f76ff0902022-12-21T18:55:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018035910.1371/journal.pone.0180359A curated catalog of canine and equine keratin genes.Pierre BalmerAnina BauerShashikant PujarKelly M McGarveyMonika WelleArnaud GalichetEliane J MüllerKim D PruittTosso LeebVidhya JagannathanKeratins represent a large protein family with essential structural and functional roles in epithelial cells of skin, hair follicles, and other organs. During evolution the genes encoding keratins have undergone multiple rounds of duplication and humans have two clusters with a total of 55 functional keratin genes in their genomes. Due to the high similarity between different keratin paralogs and species-specific differences in gene content, the currently available keratin gene annotation in species with draft genome assemblies such as dog and horse is still imperfect. We compared the National Center for Biotechnology Information (NCBI) (dog annotation release 103, horse annotation release 101) and Ensembl (release 87) gene predictions for the canine and equine keratin gene clusters to RNA-seq data that were generated from adult skin of five dogs and two horses and from adult hair follicle tissue of one dog. Taking into consideration the knowledge on the conserved exon/intron structure of keratin genes, we annotated 61 putatively functional keratin genes in both the dog and horse, respectively. Subsequently, curators in the RefSeq group at NCBI reviewed their annotation of keratin genes in the dog and horse genomes (Annotation Release 104 and Annotation Release 102, respectively) and updated annotation and gene nomenclature of several keratin genes. The updates are now available in the NCBI Gene database (https://www.ncbi.nlm.nih.gov/gene).http://europepmc.org/articles/PMC5573215?pdf=render |
| spellingShingle | Pierre Balmer Anina Bauer Shashikant Pujar Kelly M McGarvey Monika Welle Arnaud Galichet Eliane J Müller Kim D Pruitt Tosso Leeb Vidhya Jagannathan A curated catalog of canine and equine keratin genes. PLoS ONE |
| title | A curated catalog of canine and equine keratin genes. |
| title_full | A curated catalog of canine and equine keratin genes. |
| title_fullStr | A curated catalog of canine and equine keratin genes. |
| title_full_unstemmed | A curated catalog of canine and equine keratin genes. |
| title_short | A curated catalog of canine and equine keratin genes. |
| title_sort | curated catalog of canine and equine keratin genes |
| url | http://europepmc.org/articles/PMC5573215?pdf=render |
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