Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors

Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors

Metastasis is the major cause of death in colorectal cancer and it has been proven that inhibiting an interaction between adenomatous polyposis coli (APC) and Rho guanine nucleotide exchange factor 4 (Asef) efficaciously restrain metastasis. However, current inhibitors cannot achieve a satisfying ef...

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Bibliographic Details
Main Authors: Xinheng He, Ning Huang, Yuran Qiu, Jian Zhang, Yaqin Liu, Xiao-Lan Yin, Shaoyong Lu
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
APC-Asef
protein-protein interactions (PPIs)
molecular dynamics (MD) simulations
protein dynamics
peptide drug design
Online Access:https://www.mdpi.com/1420-3049/26/4/962

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