The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases
Purpose: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. Methods: The study concerned a retrospective review of 594...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Journal of Clinical & Translational Endocrinology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214623718301261 |
| _version_ | 1828344360286027776 |
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| author | Calogero Cipolla Giuseppa Graceffa Sergio Calamia Eugenio Fiorentino Gianni Pantuso Salvatore Vieni Mario Latteri |
| author_facet | Calogero Cipolla Giuseppa Graceffa Sergio Calamia Eugenio Fiorentino Gianni Pantuso Salvatore Vieni Mario Latteri |
| author_sort | Calogero Cipolla |
| collection | DOAJ |
| description | Purpose: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. Methods: The study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves’ disease. The incidence of complications and outcomes on hyperthyroidism and correlated symptoms resolution were also evaluated. Results: The mean age of the patients was of 44.7 ± 12.7 years and 456 patients (76.7%) were females. The mean gland weight was 67.3 ± 10.8 g (range: 20–350 g) and, in 397 patients (66.8%), the gland weighed >40 g. The mean operative time was 125 ± 23.1 min (range: 65–212 min). Temporary and permanent hypocalcaemia developed in 241 (40.6%) and 3 patients (0.5%), respectively. Temporary and permanent recurrent laryngeal nerve palsy were recorded in 31 (5.2%) and 1 patients (0.16%) respectively. No patient developed a thyroid storm. On multivariate analysis, patient age ≤50 years (Odds ratio: 1; 95% Confidence Interval: 0.843–0.901) and thyroid weight >40 g (Odds ratio: 1; 95%, Confidence Interval: 0.852–0.974), were mainly associated with the occurrence of complications. Conclusion: This high-volume surgeon experience demonstrates that total thyroidectomy is a safe and effective treatment for Graves’ disease. It is associated with a very low incidence rate of post-operative complications, most of which are transitory; therefore, it offers a rapid and definitive control of hyperthyroidism and its related symptoms. Keywords: Graves’ disease, Total thyroidectomy, Complications |
| first_indexed | 2024-04-13T23:56:10Z |
| format | Article |
| id | doaj.art-fbd9658207db48219436a00361555ae0 |
| institution | Directory Open Access Journal |
| issn | 2214-6237 |
| language | English |
| last_indexed | 2024-04-13T23:56:10Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical & Translational Endocrinology |
| spelling | doaj.art-fbd9658207db48219436a00361555ae02022-12-22T02:23:54ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372019-06-0116The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 casesCalogero Cipolla0Giuseppa Graceffa1Sergio Calamia2Eugenio Fiorentino3Gianni Pantuso4Salvatore Vieni5Mario Latteri6Corresponding author at: University of Palermo, Department of Surgical Oncological and Oral Sciences, Via del Vespro 129, 90127 Palermo, Italy.; University of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, ItalyUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, ItalyUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, ItalyUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, ItalyUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, ItalyUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, ItalyUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, ItalyPurpose: Thyroidectomy is the preferred approach as the definitive treatment for Graves’ disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. Methods: The study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves’ disease. The incidence of complications and outcomes on hyperthyroidism and correlated symptoms resolution were also evaluated. Results: The mean age of the patients was of 44.7 ± 12.7 years and 456 patients (76.7%) were females. The mean gland weight was 67.3 ± 10.8 g (range: 20–350 g) and, in 397 patients (66.8%), the gland weighed >40 g. The mean operative time was 125 ± 23.1 min (range: 65–212 min). Temporary and permanent hypocalcaemia developed in 241 (40.6%) and 3 patients (0.5%), respectively. Temporary and permanent recurrent laryngeal nerve palsy were recorded in 31 (5.2%) and 1 patients (0.16%) respectively. No patient developed a thyroid storm. On multivariate analysis, patient age ≤50 years (Odds ratio: 1; 95% Confidence Interval: 0.843–0.901) and thyroid weight >40 g (Odds ratio: 1; 95%, Confidence Interval: 0.852–0.974), were mainly associated with the occurrence of complications. Conclusion: This high-volume surgeon experience demonstrates that total thyroidectomy is a safe and effective treatment for Graves’ disease. It is associated with a very low incidence rate of post-operative complications, most of which are transitory; therefore, it offers a rapid and definitive control of hyperthyroidism and its related symptoms. Keywords: Graves’ disease, Total thyroidectomy, Complicationshttp://www.sciencedirect.com/science/article/pii/S2214623718301261 |
| spellingShingle | Calogero Cipolla Giuseppa Graceffa Sergio Calamia Eugenio Fiorentino Gianni Pantuso Salvatore Vieni Mario Latteri The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases Journal of Clinical & Translational Endocrinology |
| title | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
| title_full | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
| title_fullStr | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
| title_full_unstemmed | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
| title_short | The value of total thyroidectomy as the definitive treatment for Graves’ disease: A single centre experience of 594 cases |
| title_sort | value of total thyroidectomy as the definitive treatment for graves disease a single centre experience of 594 cases |
| url | http://www.sciencedirect.com/science/article/pii/S2214623718301261 |
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