PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil

PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil

Abstract Background Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear receptor family. It is involved in the regulation of adipogenesis, lipid metabolism, insulin sensitivity, vascular homeostasis and inflammation. In addition, PPARG agonists, known as thiazolidined...

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Bibliographic Details
Main Authors: Leah Schöckel, Christine Woischke, Sai Agash Surendran, Marlies Michl, Tobias Schiergens, Andreas Hölscher, Florian Glass, Peter Kreissl, Frederick Klauschen, Michael Günther, Steffen Ormanns, Jens Neumann
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cancer
Subjects:
Colorectal cancer; metastasis
Diabetes mellitus
PPARG
5-fluorouracil
Online Access:https://doi.org/10.1186/s12885-024-11985-5

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