Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy
Long noncoding RNAs (lncRNAs) have been proven to play critical roles in diabetic retinopathy (DR). This study investigated whether the single nucleotide polymorphism (SNP) of long intergenic noncoding RNA 00673 (LINC00673) affects the clinical characteristics of diabetic retinopathy (DR). A total o...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.889530/full |
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| author | Chih-Chun Chuang Chih-Chun Chuang Yi-Sun Yang Yi-Sun Yang Edy Kornelius Edy Kornelius Chien-Ning Huang Chien-Ning Huang Chien-Ning Huang Min-Yen Hsu Min-Yen Hsu Chia-Yi Lee Shun-Fa Yang Shun-Fa Yang |
| author_facet | Chih-Chun Chuang Chih-Chun Chuang Yi-Sun Yang Yi-Sun Yang Edy Kornelius Edy Kornelius Chien-Ning Huang Chien-Ning Huang Chien-Ning Huang Min-Yen Hsu Min-Yen Hsu Chia-Yi Lee Shun-Fa Yang Shun-Fa Yang |
| author_sort | Chih-Chun Chuang |
| collection | DOAJ |
| description | Long noncoding RNAs (lncRNAs) have been proven to play critical roles in diabetic retinopathy (DR). This study investigated whether the single nucleotide polymorphism (SNP) of long intergenic noncoding RNA 00673 (LINC00673) affects the clinical characteristics of diabetic retinopathy (DR). A total of three loci of LINC00673 SNPs (rs6501551, rs9914618, and rs11655237) were genotyped using TaqMan allelic discrimination in 276 and 454 individuals with and without DR, respectively. Our results revealed that LINC00673 SNP rs11655237 CT genotype (AOR: 1.592, 95% CI: 1.059–2.395, p = 0.026), CT + TT genotype (AOR: 1.255, 95% CI: 1.029–1.531, p = 0.025), and allele T (AOR: 1.185, 95% CI: 1.004–1.397, p = 0.044) yielded higher ratios in the non-proliferative diabetic retinopathy (NPDR) subgroup than in the non-DR group. Furthermore, the interval of diabetes mellitus (DM) was significantly shorter in the LINC00673 SNP rs11655237 CT + TT variant than that in the LINC00673 SNP rs11655237 wild type (10.44 ± 7.10 vs. 12.98 ± 8.34, p = 0.009). In conclusion, the LINC00673 SNP rs11655237 T allele is associated with a higher probability of NPDR development. Patients with the LINC00673 SNP rs11655237 CT + TT variant exhibited a short DM interval. |
| first_indexed | 2024-04-14T00:42:01Z |
| format | Article |
| id | doaj.art-fbdb73acafdd4981aa87d3cd017fab28 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-14T00:42:01Z |
| publishDate | 2022-04-01 |
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| spelling | doaj.art-fbdb73acafdd4981aa87d3cd017fab282022-12-22T02:22:09ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.889530889530Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic RetinopathyChih-Chun Chuang0Chih-Chun Chuang1Yi-Sun Yang2Yi-Sun Yang3Edy Kornelius4Edy Kornelius5Chien-Ning Huang6Chien-Ning Huang7Chien-Ning Huang8Min-Yen Hsu9Min-Yen Hsu10Chia-Yi Lee11Shun-Fa Yang12Shun-Fa Yang13Institute of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Ophthalmology, Changhua Christian Hospital, Changhua, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Chung Shan Medical University Hospital, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Chung Shan Medical University Hospital, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Chung Shan Medical University Hospital, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Ophthalmology, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Ophthalmology, Nobel Eye Institute, Taipei, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, TaiwanLong noncoding RNAs (lncRNAs) have been proven to play critical roles in diabetic retinopathy (DR). This study investigated whether the single nucleotide polymorphism (SNP) of long intergenic noncoding RNA 00673 (LINC00673) affects the clinical characteristics of diabetic retinopathy (DR). A total of three loci of LINC00673 SNPs (rs6501551, rs9914618, and rs11655237) were genotyped using TaqMan allelic discrimination in 276 and 454 individuals with and without DR, respectively. Our results revealed that LINC00673 SNP rs11655237 CT genotype (AOR: 1.592, 95% CI: 1.059–2.395, p = 0.026), CT + TT genotype (AOR: 1.255, 95% CI: 1.029–1.531, p = 0.025), and allele T (AOR: 1.185, 95% CI: 1.004–1.397, p = 0.044) yielded higher ratios in the non-proliferative diabetic retinopathy (NPDR) subgroup than in the non-DR group. Furthermore, the interval of diabetes mellitus (DM) was significantly shorter in the LINC00673 SNP rs11655237 CT + TT variant than that in the LINC00673 SNP rs11655237 wild type (10.44 ± 7.10 vs. 12.98 ± 8.34, p = 0.009). In conclusion, the LINC00673 SNP rs11655237 T allele is associated with a higher probability of NPDR development. Patients with the LINC00673 SNP rs11655237 CT + TT variant exhibited a short DM interval.https://www.frontiersin.org/articles/10.3389/fgene.2022.889530/fulllong intergenic noncoding RNA 00673polymorphismdiabetic retinopathydiabetes mellitusdisease duration |
| spellingShingle | Chih-Chun Chuang Chih-Chun Chuang Yi-Sun Yang Yi-Sun Yang Edy Kornelius Edy Kornelius Chien-Ning Huang Chien-Ning Huang Chien-Ning Huang Min-Yen Hsu Min-Yen Hsu Chia-Yi Lee Shun-Fa Yang Shun-Fa Yang Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy Frontiers in Genetics long intergenic noncoding RNA 00673 polymorphism diabetic retinopathy diabetes mellitus disease duration |
| title | Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy |
| title_full | Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy |
| title_fullStr | Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy |
| title_full_unstemmed | Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy |
| title_short | Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy |
| title_sort | impact of long noncoding rna linc00673 genetic variants on susceptibility to diabetic retinopathy |
| topic | long intergenic noncoding RNA 00673 polymorphism diabetic retinopathy diabetes mellitus disease duration |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.889530/full |
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