Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice.

Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice.

Histones package DNA and regulate epigenetic states. For the latter, probably the most important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can accumulate in slowly dividing somatic cells, replacin...

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Bibliographic Details
Main Authors: Michelle C W Tang, Shelley A Jacobs, Deidre M Mattiske, Yu May Soh, Alison N Graham, An Tran, Shu Ly Lim, Damien F Hudson, Paul Kalitsis, Moira K O'Bryan, Lee H Wong, Jeffrey R Mann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4335506?pdf=render

Internet

http://europepmc.org/articles/PMC4335506?pdf=render

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