The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes
In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes. In menopausal period, female patients experience gradual reduction in blood estradiol levels....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2014-06-01
|
| Series: | Current Issues in Pharmacy and Medical Sciences |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/cipms.2014.27.issue-2/cipms-2014-0021/cipms-2014-0021.xml?format=INT |
| _version_ | 1818585591799873536 |
|---|---|
| author | Rahnama Mansur Lobacz Michal Szyszkowska Anna Trybek Grzegorz Kozicka-Czupkallo Maryla |
| author_facet | Rahnama Mansur Lobacz Michal Szyszkowska Anna Trybek Grzegorz Kozicka-Czupkallo Maryla |
| author_sort | Rahnama Mansur |
| collection | DOAJ |
| description | In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes. In menopausal period, female patients experience gradual reduction in blood estradiol levels. The deficit of estrogens leads to enhanced osteoclastogenesis and bone resorption. Alkaline phosphatase (ALP) is a membranebound enzyme that stimulates the osteoblast activity and bone mineralization. It is synthesized by osteoblasts and incorporated into the newly formed bone tissue. The produced enzyme stimulates the osteoblast activity and bone mineralization. The goal of this study is to determine the effect of hormone replacement therapy in postmenopausal women on the expression of alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes. The studies show that hormone replacement therapy has no significant effect on the increase in ALPL expression within the mucosal epithelium of the cheek. Only in women having undergone ovarectomy (OV), the epithelial ALPL expression level was higher than in the remaining groups. |
| first_indexed | 2024-12-16T08:39:31Z |
| format | Article |
| id | doaj.art-fbdc2a3dba48408cba2a98032a02234b |
| institution | Directory Open Access Journal |
| issn | 2084-980X 2300-6676 |
| language | English |
| last_indexed | 2024-12-16T08:39:31Z |
| publishDate | 2014-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj.art-fbdc2a3dba48408cba2a98032a02234b2022-12-21T22:37:43ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2084-980X2300-66762014-06-01272929610.2478/cipms-2014-0021cipms-2014-0021The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytesRahnama Mansur0Lobacz Michal1Szyszkowska Anna2Trybek Grzegorz3Kozicka-Czupkallo Maryla4Chair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7, 20-081 Lublin, PolandChair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7, 20-081 Lublin, PolandChair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7, 20-081 Lublin, PolandDepartment of Oral Surgery, Pomeranian Medical University, al. Powstańców Wlkp. 72, 70-111 Szczecin, PolandChair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7, 20-081 Lublin, PolandIn adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes. In menopausal period, female patients experience gradual reduction in blood estradiol levels. The deficit of estrogens leads to enhanced osteoclastogenesis and bone resorption. Alkaline phosphatase (ALP) is a membranebound enzyme that stimulates the osteoblast activity and bone mineralization. It is synthesized by osteoblasts and incorporated into the newly formed bone tissue. The produced enzyme stimulates the osteoblast activity and bone mineralization. The goal of this study is to determine the effect of hormone replacement therapy in postmenopausal women on the expression of alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes. The studies show that hormone replacement therapy has no significant effect on the increase in ALPL expression within the mucosal epithelium of the cheek. Only in women having undergone ovarectomy (OV), the epithelial ALPL expression level was higher than in the remaining groups.http://www.degruyter.com/view/j/cipms.2014.27.issue-2/cipms-2014-0021/cipms-2014-0021.xml?format=INTalkaline phosphatasebone turnover markersmenopausal periodovarectomy hormone replacement therapy |
| spellingShingle | Rahnama Mansur Lobacz Michal Szyszkowska Anna Trybek Grzegorz Kozicka-Czupkallo Maryla The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes Current Issues in Pharmacy and Medical Sciences alkaline phosphatase bone turnover markers menopausal period ovarectomy hormone replacement therapy |
| title | The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes |
| title_full | The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes |
| title_fullStr | The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes |
| title_full_unstemmed | The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes |
| title_short | The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes |
| title_sort | effect of hormone replacement therapy on the expression of the alkaline phosphatase gene alpl within the mucosal epithelium of the cheek and in peripheral blood lymphocytes |
| topic | alkaline phosphatase bone turnover markers menopausal period ovarectomy hormone replacement therapy |
| url | http://www.degruyter.com/view/j/cipms.2014.27.issue-2/cipms-2014-0021/cipms-2014-0021.xml?format=INT |
| work_keys_str_mv | AT rahnamamansur theeffectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT lobaczmichal theeffectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT szyszkowskaanna theeffectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT trybekgrzegorz theeffectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT kozickaczupkallomaryla theeffectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT rahnamamansur effectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT lobaczmichal effectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT szyszkowskaanna effectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT trybekgrzegorz effectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes AT kozickaczupkallomaryla effectofhormonereplacementtherapyontheexpressionofthealkalinephosphatasegenealplwithinthemucosalepitheliumofthecheekandinperipheralbloodlymphocytes |